Role of redox imbalance and cytokines in mediating oxidative damage and disease progression of patients with rheumatoid arthritis

Pradhan, Ayan; Bagchi, Aniruddha; De, Soumita; Mitra, Sneha; Mukherjee, Shibabrata; Ghosh, Parasar; Ghosh, Alakendu; Chatterjee, Mitali

doi:10.1080/10715762.2019.1629586

Cited by 39 publications

(25 citation statements)

References 43 publications

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“…Thus, an imbalance of cytokine network contributes to the development and progression of this autoimmune disease. In particular, TNF-α, IL-6, IL-1β and IFN-γ are considered to be disease promoting cytokines in RA [33,34]. In synovium, patients with RA had high frequencies of Th1 cells and of Th17 cells, which are thought to play a prominent pathogenic role in autoimmune arthritis.…”

Section: Discussionmentioning

confidence: 99%

“…In synovium, patients with RA had high frequencies of Th1 cells and of Th17 cells, which are thought to play a prominent pathogenic role in autoimmune arthritis. More recently, in plasma from RA patients, levels of IL-17, IL-23 and IFN-γ were significantly increased and correlated with a redox imbalance and oxidative damage [34]. Moreover, COMP, a specific serological marker which evaluates the articular cartilage degradation and its turnover, exerts an active role in inflammation.…”

Section: Discussionmentioning

confidence: 99%

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A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation

et al. 2021

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Oleuropein (OL), an olive tree secoiridoid and its peracetylated derivate (Per-OL) have exhibited several beneficial effects on LPS-stimulated macrophages and murine experimental systemic lupus erythematosus (SLE). This study was designed to evaluate dietary Per-OL in comparison with OL supplementation effects on collagen-induced arthritis (CIA) murine model. Three-weeks-old DBA-1/J male mice were fed from weaning with a standard commercial diet or experimental enriched-diets in 0.05 % (w/w) OL, 0.05% and 0.025% Per-OL. After six weeks of pre-treatment, arthritis was induced by bovine collagen type II by tail base injection (day 0) and on day 21, mice received a booster injection. Mice were sacrificed 42 days after the first immunization. Both Per-OL and OL diets significantly prevented histological damage and arthritic score development, although no statistically significant differences were observed between both compounds. Also, serum collagen oligomeric matrix protein (COMP), metalloprotease (MMP)-3 and pro-inflammatory cytokines levels were ameliorated in paws from secoiridoids fed animals. Mitogen-activated protein kinases (MAPK)s and nuclear transcription factor-kappa-B (NF-κB) activations were drastically down-regulated whereas nuclear factor E2-related factor 2 (Nrf2) and heme-oxygenase-1 (HO-1) protein expressions were up-regulated in those mice fed with OL and Per-OL diets. We conclude that both Per-OL and its parent compound, OL, supplements might provide a basis for developing a new dietary strategy for the prevention of rheumatoid arthritis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation

et al. 2021

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“…Oxidative damages may aggravate mitochondrial dysfunctions and further accelerate the progression of sarcopenia. The hypothesis that mitochondrial dysfunctions could be involved in sarcopenia in RA patients could be drawn from the observation that oxidative stress was linked to chronic inflammation and RA [72]. The correlation between ROS production and the loss of handgrip strength in older women [73], the contribution of oxidative stress to skeletal muscle dysfunction in an animal models of RA [74] further corroborated this hypothesis.…”

Section: Mitochondrial Dysfunctionmentioning

confidence: 84%

Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?

2020

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Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by a high prevalence of death due to cardiometabolic diseases. As observed during the aging process, several comorbidities, such as cardiovascular disorders (CVD), insulin resistance, metabolic syndrome and sarcopenia, are frequently associated to RA. These abnormalities could be closely linked to alterations in lipid metabolism. Indeed, RA patients exhibit a lipid paradox, defined by reduced levels of total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol whereas the CVD risk is increased. Moreover, the accumulation of toxic lipid mediators (i.e., lipotoxicity) in skeletal muscles can induce mitochondrial dysfunctions and insulin resistance, which are both crucial determinants of CVD and sarcopenia. The prevention or reversion of these biological perturbations in RA patients could contribute to the maintenance of muscle health and thus be protective against the increased risk for cardiometabolic diseases, dysmobility and mortality. Yet, several studies have shown that omega 3 fatty acids (FA) could prevent the development of RA, improve muscle metabolism and limit muscle atrophy in obese and insulin-resistant subjects. Thereby, dietary supplementation with omega 3 FA should be a promising strategy to counteract muscle lipotoxicity and for the prevention of comorbidities in RA patients.

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“…This results in a vicious cycle of cell death and greater inflammation [29]. This ROS-inflammation axis has been studied in a wide array of inflammatory-based diseases, such as cardiac alterations [30][31][32], bone and joint diseases [33][34][35], neuronal and cerebral dysfunctions [28,29,36], bacterial infection [37], liver diseases [38], respiratory alterations [39,40] and cancer [41]. Furthermore, in T2D, the continuous presence of proinflammatory molecules causes diverse endocrine effects on the vasculature, and contributes to the development of micro-and macrovascular pathologies such as carotid atherosclerosis [21].…”

Section: Introductionmentioning

confidence: 99%

Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control

Iannantuoni

Abad-Jiménez

Canet

et al. 2020

JCM

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Glycated hemoglobin monitorization could be a tool for maintaining type 2 diabetes (T2D) under control and delaying the appearance of cardiovascular events. This cross-sectional study was designed to assess the role of glycemic control in modulating early-stage markers of cardiovascular complications. One hundred and eight healthy controls and 161 type 2 diabetic patients were recruited and distributed according to their glycemic control, setting the threshold at 6.5% (good control). Biochemical and anthropometrical parameters were registered during the initial visit, and peripheral blood was extracted to obtain polymorphonuclear cells and analyze inflammatory markers, adhesion molecules, leukocyte–endothelium interactions, and carotid intima–media thickness. Correlations between these parameters were explored. We found that inflammatory markers and adhesion molecules were augmented in type 2 diabetic subjects with poor glycemic control. Polymorphonuclear leukocytes interacted more with the endothelium in the diabetic population, and even more significantly in the poorly controlled subjects. In parallel, carotid intima–media thickness was also increased in the diabetic population, and the difference was greater among poorly controlled subjects. Finally, correlation measurement revealed that carotid intima–media thickness was related to glycemic control and lipid metabolism in diabetic patients. Our results suggest that glycemic control delays the onset of cardiovascular comorbidities in diabetic subjects.

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Role of redox imbalance and cytokines in mediating oxidative damage and disease progression of patients with rheumatoid arthritis

Cited by 39 publications

References 43 publications

A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation

A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation

Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?

Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control

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