Role of Redox Metals, Oxidative Protein Products and Antioxidant Potentials of Thiols in Diabetic Retinopathy

Sindhu, P. J.; Shetty, Beena; Sudha, K; Rao, Gayathri M

doi:10.2478/v10011-011-0045-z

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Dynamic thioldisulphide homeostasis has an important role in cell signalling mechanisms, transcription factors, regulation of enzymatic reactions, signal transduction, antioxidant protection and detoxification (8, 9). Abnor malities in dynamic thiol-disulphide homeostasis have been proven in solid organ malignancies such as prostate cancer (10), hematological malignancies such as multiple myeloma (11), cardiovascular diseases (12), polycystic ovary syndrome (13) and diabetes mellitus (14). The dynamic thiol-disulphide homeostasis status was first detected in 1979.…”

Section: Introductionmentioning

confidence: 99%

Thiol-disulphide homeostasis in essential thrombocythemia patients

Yıkılmaz

Bakanay

Akıncı³

et al. 2019

Journal of Medical Biochemistry

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Summary Background This study aimed to show the status of thioldisulphide homeostasis in essential thrombocytosis patients, which is known to play a role in platelet function. Methods The study included 27 ET patients and a control group of 36 healthy subjects. Serum total (–SH + –S–S–) and native (–SH) thiol levels were measured in all subjects using an automatic method. Results Age and gender distribution were similar in both groups. Compared with the control group, in the ET group, there were increased native thiol and total thiol levels (p = 0.001, p = 0.046). There was no correlation between thiol, total thiol and disulphide ratios with Jak2 mutation, hemorrhage and thrombosis. A positive correlation was determined between thrombosis and thiol disulphide homeostasis (p = 0.058). The study results showed that thiol-disulphide homeostasis shifted to the proliferative side in ET, in which ineffective erythropoiesis was predominant. It is also known that platelets are more active in ET cases and thiol disulphide balance is important in platelet function. Conclusions This result suggests that thrombotic complications may be reduced if the formation is achieved of mechanisms (oxidation mechanisms) that will trigger the increase of disulphide groups. However, more extensive research is needed on this subject.

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Section: Introductionmentioning

confidence: 99%

Thiol-disulphide homeostasis in essential thrombocythemia patients

Yıkılmaz

Bakanay

Akıncı³

et al. 2019

Journal of Medical Biochemistry

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Nutrition for diabetic retinopathy: plummeting the inevitable threat of diabetic vision loss

et al. 2017

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Diabetic retinopathy (DR) is among the leading causes of preventable blindness. Hyperglycemia, hypertension, hyperlipidemia and anemia majorly predispose its pathogenesis. The current treatment modalities of DR include laser photocoagulation therapy, intravitreal corticosteroids, intravitreal anti-vascular endothelial growth factor (VEGF) agents and vitreo-retinal surgery which are costly, highly invasive, unproven for prolonged use and opted in advanced stages of DR. By then retina already encounters a vast damage. Nutrients by their natural physiological, biochemical and molecular action can preserve retinal structure and functions by interfering with the various pathological steps prompting DR incidence, thereby altering the risk of developing this ocular morbidity. Nutrients can also play a central role in DR patients resistant towards the conventional medical treatments. However due to the byzantine interplay existing between nutrients and DR, the worth of nutrition in curbing this vision-threatening ocular morbidity remains silent. This review highlights how nutrients can halt DR development. A nutritional therapy, if adopted in the initial stages, can provide superior-efficacy over the current treatment modalities and can be a complementary, inexpensive, readily available, anodyne option to the clinically unmet requirement for preventing DR. Assessment of nutritional status is presently considered relevant in various clinical conditions except DR. Body Mass Index (BMI) conferred inconclusive results in DR subjects. Subjective Global Assessment (SGA) of nutritional status has recently furnished relevant association with DR status. By integrating nutritional strategies, the risk of developing DR can be reduced substantially. This review summarizes the subsisting knowledge on nutrition, potentially beneficial for preventing DR and sustaining good vision among diabetic subjects.

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The metallome of the human placenta in gestational diabetes mellitus

et al. 2015

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Obtaining the knowledge of the "omics" and therefore of the metallomics of gestational diabetes mellitus (GDM) appears to be a necessary task to obtain information about the molecular causes of this disease. In this study, the metallome of GDM and of other types of diabetes mellitus was first reviewed. The comparative analysis of the published data revealed that no GDM elemental markers could be identified with sufficient reliability in blood or in the other considered samples, with the partial exception of selenium. The placenta was chosen as an alternative target organ for the analysis of the GDM metallome. The full elemental average composition of 19 healthy placentas was obtained by ICP-MS. Analyses were then performed on 28 placentas from women affected by GDM. The statistical tests and the principal component analysis evidenced that cadmium was found in lower concentrations and selenium was found in higher concentrations in GDM placentas than in those of the control group. These results were interpreted in light of literature data, and they attract attention on two key elements for understanding the molecular pathways of GDM.

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Role of Redox Metals, Oxidative Protein Products and Antioxidant Potentials of Thiols in Diabetic Retinopathy

Cited by 3 publications

References 30 publications

Thiol-disulphide homeostasis in essential thrombocythemia patients

Thiol-disulphide homeostasis in essential thrombocythemia patients

Nutrition for diabetic retinopathy: plummeting the inevitable threat of diabetic vision loss

The metallome of the human placenta in gestational diabetes mellitus

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