Role of regenerative therapies on erectile dysfunction after radical prostatectomy

Hansen, Steinbjørn; Lund, Martin; Østergaard, Louise Dorner; Lund, Lars

doi:10.1038/s41443-020-00406-3

Cited by 5 publications

(4 citation statements)

References 58 publications

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“…A large number of bioactive factors are also released in a paracrine manner by implanted stem cells, thereby improving the local pathological environment and accelerating tissue repair. 41 , 59 However, more and more studies have documented that paracrine effects seem to be the primary mechanism of SCT compared with cellular differentiation effects. 10 , 18 Only a small number of stem cells could be detected after transplantation.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction

Sun,

Liu,

Yuan

et al. 2024

DDDT

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Purpose As a common male disease, erectile dysfunction (ED) seriously affects the physical and mental health of patients. In recent years, studies have continued to point out the great potential of stem cell therapy (SCT) in the treatment of ED. The purpose of this study is to comprehensively analyze the research of SCT for ED and understand the development trends and research frontiers in this field. Methods Publications regarding SCT and ED were retrieved and collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were then utilized for bibliometric and visualization analysis. Results A total of 524 publications were eventually included in this study. The annual number of publications in this field was increasing year by year. China and the USA were the two most productive countries. Lin GT, Lue TF and Lin CS, and the University of California San Francisco where they worked were the most productive research group and institution, respectively. The journal with the largest number of publications was The Journal of Sexual Medicine, and the following were mostly professional journals of urology and andrology. Diabetes mellitus-induced ED and cavernous nerve injury-related ED were the two most commonly constructed models of ED in studies. Concerning the types of stem cells, mesenchymal stem cells derived from adipose and bone marrow were most frequently used. Moreover, future research would mainly focus on exosomes, tissue engineering technology, extracorporeal shockwave therapy, and clinical translation. Conclusion The research of SCT for ED will receive increasing global attention in the future. Our study provided bibliometric and visualization analysis of published literature, helping researchers understand the global landscape and frontiers in this field. More preclinical and clinical studies should be conducted to more deeply explore the underlying mechanisms of treatment and promote clinical translation.

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Section: Discussionmentioning

confidence: 99%

Bibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction

Sun,

Liu,

Yuan

et al. 2024

DDDT

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“…SCT had undergone several clinical trials to reveal that it could safely enhance EF in people with post-RP ED [9]. Hansen et al [16] described improvement in EF by utilizing SCT as a safe option. This claim of stem cells as a viable treatment for ED needed further evidence from large randomized human phase 2 studies.…”

Section: Discussionmentioning

confidence: 99%

“…This claim of stem cells as a viable treatment for ED needed further evidence from large randomized human phase 2 studies. However, the outcomes of animal and human trials for the stem cells as restorative therapy are encouraging [16].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of stem cell therapy in erectile dysfunction after radical prostatectomy: a comprehensive systematic review

2024

JOMH

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Around 68% patients undergoing radical prostatectomy face postoperative erectile dysfunction. This systematic review aims to investigate the studies pertaining to efficacy of stem cell therapy in alleviating erectile dysfunction (ED) of radical prostatectomy (RP) patients. Furthermore, it provides evidence-based potential benefits of stem cell therapy in addressing erectile dysfunction of those patients. A systematic literature search from PubMed, Google Scholar, Science Direct and clinicaltrial.gov databases was conducted for the clinical trials evaluating efficacy and safety of stem cell therapy in post-prostatectomy erectile dysfunction. The inclusion criteria pertained to the studies reporting pre-and post-outcome erectile function and safety results. Cochrane Robins I was employed for the quality and bias risk. Four studies were finally included. The studies were of high quality as revealed from the quality assessment results. They were the non-randomized human-based clinical trials. Patients follow-up ranged from 3 to 12 months. Intercourse satisfaction scores were improved after 6 and 12 months of stem cell therapy. No serious adversities were reported during and after the study period. It was thus a safe therapeutic option as per these results. This study evaluated the role of stem cell therapy in post-RP ED. The included studies depicted its efficacy and safety. The information on stem cell therapy for ED was limited, however it could provide foundation for future research. Large-scale human studies with robust research designs would bring more objectivity and conclusive evidence.

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“…28,33 Regenerative therapies with stem cells have been shown to be effective in men who have undergone radical prostatectomy for prostate cancer treatment, as well has patients experiencing ED from diabetes mellitus. 34,35 The AUA currently lists ICI with stem cell therapy as a grade C recommendation for men with ED, stating the therapy should be considered "investigational". 14 PRP injection therapy has been studied in rodent models and humans, and has been associated with the potential mechanism of action of nerve regeneration.…”

Section: Erectile Dysfunctionmentioning

confidence: 99%

Male Sexual Dysfunction

Anderson

Laforge

Ross

et al. 2022

Health Psychology Research

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Male sexual dysfunction is a series of conditions, most notably including erectile dysfunction (ED), Peyronie’s disease (PD), and premature ejaculation (PE), defined by impaired sexual functioning. The prevalence of male sexual dysfunction increases with age and is relatively high with greater than 50% of men aged 40 to 70 describing some degree of erectile dysfunction. Risk factors for male sexual dysfunction include age, diabetes mellitus (DM), cancer, stroke, hypertension, penile trauma, depression, anxiety, and disturbance in central serotonin neurotransmission and 5-HT postsynaptic receptor functioning. Sexual questionnaires including the International Index of Erectile Dysfunction, Sexual Health Inventory for Men, and the Premature Ejaculation Diagnostic Tool are useful in screening for these disorders. Focused history and physical can establish diagnoses. For a condition to be diagnosed as male sexual dysfunction, the patient or their partner must view their sexual functioning as impaired. Treatment of male sexual dysfunction is etiology dependent. For ED, first-line therapy is a phosphodiesterase-5 inhibitor or mental health care for psychogenic ED. More complicated cases may be treated with injections, surgery, or shockwave therapy. PD is either treated with medications for pain management, collagenase clostridium histolyticum injection, corpoplasty, plication, or shockwave therapy. PE may be treated behaviorally or with SSRIs as first line medication.

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Role of regenerative therapies on erectile dysfunction after radical prostatectomy

Cited by 5 publications

References 58 publications

Bibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction

Bibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction

Evaluation of the efficacy of stem cell therapy in erectile dysfunction after radical prostatectomy: a comprehensive systematic review

Male Sexual Dysfunction

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