2006
DOI: 10.1124/jpet.106.105973
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Role of Renal Nerves and Salt Intake on Erythropoietin Secretion in Rats following Carbon Monoxide Exposure

Abstract: Because the data from the literature contain conflicting results regarding the role of renal nerves and angiotensin II in hypoxiainduced erythropoietin (EPO) secretion, we evaluated the effect of renal nerves and salt intake in rats on EPO secretion stimulated by carbon monoxide (CO). Serum levels and renal mRNA content of EPO were similarly elevated by exposure to different CO concentrations in a dose-dependent manner in rats with bilateral renal denervation (DNX) and in sham-denervated controls (INN). Howeve… Show more

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Cited by 4 publications
(4 citation statements)
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“…It is well known that under hypoxic or anaemic conditions, when arterial pO 2 is lowered, the EPO production increases in the renal tissue [18,[32][33][34][35][36]. Our data are in accordance with these previous studies and show that under CO exposure rat kidney cells can serve as experimental model for transcriptionally active nuclei.…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…It is well known that under hypoxic or anaemic conditions, when arterial pO 2 is lowered, the EPO production increases in the renal tissue [18,[32][33][34][35][36]. Our data are in accordance with these previous studies and show that under CO exposure rat kidney cells can serve as experimental model for transcriptionally active nuclei.…”
Section: Discussionsupporting
confidence: 82%
“…The actual CO concentration was monitored by a CO sensor (Testo, Reutlingen). The deleterious effects of high CO concentrations in the inspired air on humans and animals have been reviewed and described by many authors [16][17][18]. After 4h of CO exposure rats were anesthetized with thiopental 90mg/kg i.p.…”
Section: Animal Preparationmentioning
confidence: 99%
“…Adenosine is known to accumulate in the kidney in response to ischemia or increased tubular workload (27,35,36) and can change intrarenal hemodynamics by induction of vasoconstriction in the kidney and thus change local O 2 concentrations (52). The enzyme ecto-5Ј-nucleotidase, converting extracellular AMP into adenosine, is present on the cell surface of interstitial cells, which also positively stained for EPO mRNA (2,9,22). Furthermore, ARs and CD73 itself are transcriptionally induced by HIF-1 (34,48).…”
Section: Discussionmentioning
confidence: 94%
“…For carbon monoxide (CO) exposure [200 to 1,400 parts per million (ppm) CO], conscious male and female mice (paired in all groups, n ϭ 5-7 per group) were placed into a ventilated cage as previously described (9). In the normobaric hypoxic group, mice were exposed to 8% O 2.…”
Section: Methodsmentioning
confidence: 99%