Role of respiratory viruses in exacerbations of primary nephrotic syndrome

MacDonald, Noni E.; Wolfish, Norman M.; McLaine, Peter N.; Phipps, Peter H.; Rossier, E

doi:10.1016/s0022-3476(86)80876-9

Cited by 145 publications

(128 citation statements)

References 7 publications

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“…[13] Infectious episodes in nephrotic patients are responsible for high morbidity and can also cause an inadequate response to corticosteroid therapy and recurrences among patients in remission. [14] In our patients, similar to the frequency of having infection, frequency of relapse has increased significantly (r=0.44; p = 0.001). According to Yap et al, in a group of children with INS responding to steroid therapy, frequent relapse and steroid dependence was found significantly higher in children who had upper respiratory tract infection and responded to initial steroid therapy after nine days.…”

Section: Discussionsupporting

confidence: 77%

Steroid Responsiveness of Children with Idiopathic Nephrotic Syndrome in Southeastern Region of Turkey

et al. 2007

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Background. Our aim was to determine the prognostic factors effective in the response to steroid treatment and relapse frequency. Patients and Methods. In this study, we evaluated 84 children with idiopathic nephrotic syndrome followed-up from 1997-2002. The variables were analyzed with respect to medical history, physical examination, laboratory findings, response to treatment, and factors associated with remissions and relapses. Our study group consisted of 62 children with minimal change nephrotic syndrome (MCNS), 11 children with focal segmental glomerulosclerosis (FSGS), and 11 children with diffuse mesangial proliferation (DMP). Results. According to response to steroids; 57.1% were steroid-sensitive with infrequent relapses, 22.6% were steroid-dependent with frequent relapses, and 20.2% were steroid-non-responders. Significantly high non-responder ratios to steroids were found in children with initial hypertension and hematuria (p < 0.05). Although patients older than six years were found to be associated with steroid nonresponse (p < 0.05), the number of relapses were found to be increased with an increasing number of infections (p < 0.05). The time period for the first relapse was found to be statistically correlated with relapse numbers of the first 6 (p = 0.001) and 12 (p = 0.01) months. Conclusion. The time span between initial presentation and remission and the number of infections were significant for relapse frequency. The existence of hematuria and hypertension and age greater than 6 years at initial presentation were associated with steroid non-responsiveness. The likelihood of developing resistance to the treatment should be emphasized early to the parents of patients bearing these risk factors, and hence the possible disappointment in the family should be prevented.

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Section: Discussionsupporting

confidence: 77%

Steroid Responsiveness of Children with Idiopathic Nephrotic Syndrome in Southeastern Region of Turkey

et al. 2007

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“…However, about 70% of the children experience relapsing course in the next 12 months nontreatment period 3 . The relapses are often precipitated by infections 6,9,14 which become troublesome for the patients as well as parents. Certain factors such as age, gender, time to response, duration of treatment of initial episode and frequency of relapses in the initial six months have been found to predict the relapses in these patients 1,10,16 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Predictors of Relapse in Children with Steroid Sensitive Nephrotic Syndrome

Bhatta

Shah

Mishra

2017

J. Nepal Paedtr. Soc.

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“…These alterations are low serum levels of immunoglobulins, particularly IgG, due fundamentally to low production and to a lesser extent to catabolism and renal losses; defect in the opsonization of bacteria; and immunosuppressive therapy [3][4] . Infectious episodes in nephrotic patients are responsible for high morbidity and can also cause an inadequate response to corticosteroid therapy and recurrences among patients in remission 5 . Determining the type of infection is important, not only from the therapeutic point of view, but also to establish preventive measures 6 .…”

Section: Introductionmentioning

confidence: 99%