Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studies

Biyong, Essi F.; Tremblay, Cyntia; Leclerc, Manon; Caron, Vicky; Alfos, Serge; Helbling, Jean‐Christophe; Rodriguez, Léa; Pernet, Vincent; Bennett, David A.; Pallet, Véronique; Calon, Frédéric

doi:10.1016/j.nbd.2021.105542

Cited by 17 publications

(9 citation statements)

References 126 publications

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“…In support of these findings, reinstating normal vitamin A levels was able to restore the protein abundance of these enzymes that most likely ameliorated the cognitive dysfunction in mice [55,58,59]. Relevant to this, Biyong and colleagues have also shown that RXR undergoes protein modification in the inferior parietal cortex that coincides with the severity of cognitive decline and accumulation of senile plaques in the cortex, suggesting that vitamin A signaling itself may be impaired [15]. Another alternative mechanism may involve gut microbiota.…”

Section: Vitamin Amentioning

confidence: 78%

“…On the other hand, vitamin A supplementation has been to be effective in lowering cognitive decline and AD pathology. Six months of vitamin A-rich diet in 3xTg mouse model of AD resulted in enhanced RXR expression in the hippocampus, lowered Aβ and phosphorylation of Tau in the hippocampus, and preserved spatial memory [15]. Five-month-old APP/PS1 transgenic mice treated with All-trans retinoic acid (ATRA) intraperitoneally for eight weeks displayed a marked decrease in Aβ deposition, Tau phosphorylation and cdk5 activity, microglial and astrocyte activation, as well as a reversal of their learning and memory deficits [16].…”

Section: Vitamin Amentioning

confidence: 95%

“…Dietary intake/ supplementation/ higher circulating levels A Associated with ↑ cognition [14] ↓ Aβ, ↓ pTau, ↑ cognition [15,16] C Positive [17,18], weak or no [19][20][21] association with AD or cognition ↓ Aβ, ↓ pTau [22] D Positive association [23], ↓ Aβ, ↑ cognition [24,25] ↑ Cognition [26] E Positive [27,28] or no association [29][30][31][32] with cognition or AD, delays cognitive decline [33][34][35] ↑ Cognition [36][37][38] K ↑ Cognition [39][40][41][42][43] -…”

Section: Vitamins Human Studies Animal Studiesmentioning

confidence: 99%

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Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

et al. 2023

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Alzheimer’s disease (AD) is the most common type of dementia that affects millions of individuals worldwide. It is an irreversible neurodegenerative disorder that is characterized by memory loss, impaired learning and thinking, and difficulty in performing regular daily activities. Despite nearly two decades of collective efforts to develop novel medications that can prevent or halt the disease progression, we remain faced with only a few options with limited effectiveness. There has been a recent growth of interest in the role of nutrition in brain health as we begin to gain a better understanding of what and how nutrients affect hormonal and neural actions that not only can lead to typical cardiovascular or metabolic diseases but also an array of neurological and psychiatric disorders. Vitamins and minerals, also known as micronutrients, are elements that are indispensable for functions including nutrient metabolism, immune surveillance, cell development, neurotransmission, and antioxidant and anti-inflammatory properties. In this review, we provide an overview on some of the most common vitamins and minerals and discuss what current studies have revealed on the link between these essential micronutrients and cognitive performance or AD.

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Section: Vitamin Amentioning

confidence: 78%

Section: Vitamin Amentioning

confidence: 95%

Section: Vitamins Human Studies Animal Studiesmentioning

confidence: 99%

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Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

et al. 2023

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“…For instance, vitamin A and its metabolite, retinoic acid, have been shown to modulate the effects of estrogen signaling by increasing aromatase and ERβ expression in rat hippocampal cultured slices [ 71 ] and by reducing tau hyperphosphorylation and amyloid toxic fragments in the hippocampus of male 3×Tg-AD mice, a widely used AD mouse model. This effect was further correlated with improved learning and memory abilities in the Y-maze [ 72 ]. However, the same phenomenon was not observed in age-matched 3×Tg-AD female mice, suggesting a clear sex-specific effect.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal Estrogen Signaling Mediates Sex Differences in Retroactive Interference

et al. 2022

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Despite being a crucial physiological function of the brain, the mechanisms underlying forgetting are still poorly understood. Estrogens play a critical role in different brain functions, including memory. However, the effects of sex hormones on forgetting vulnerabilitymediated by retroactive interference (RI), a phenomenon in which newly acquired information interferes with the retrieval of already stored information, are still poorly understood. The aim of our study was to characterize the sex differences in interference-mediated forgetting and identify the underlying molecular mechanisms. We found that adult male C57bl/6 mice showed a higher susceptibility to RI-dependent memory loss than females. The preference index (PI) in the NOR paradigm was 52.7 ± 5.9% in males and 62.3 ± 13.0% in females. The resistance to RI in female mice was mediated by estrogen signaling involving estrogen receptor α activation in the dorsal hippocampus. Accordingly, following RI, females showed higher phosphorylation levels (+30%) of extracellular signal-regulated kinase1/2 (ERK1/2) in the hippocampus. Pharmacological inhibition of ERK1/2 made female mice prone to RI. The PI was 70.6 ± 11.0% in vehicle-injected mice and 47.4 ± 10.8% following PD98059 administration. Collectively, our data suggest that hippocampal estrogen α receptor-ERK1/2 signaling is critically involved in a pattern separation mechanism that inhibits object-related RI in female mice.

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“…It remains debatable whether patients with T2DM and AD could benefit from vitamin supplementation. Vitamin A may be involved in nerve regeneration, neurodevelopment, and neurodegeneration, including AD ( 84 , 85 ). Vitamin C and E have been touted for potentially favorable anti-oxidative effects in T2DM and AD ( 86 , 87 ).…”

Section: Nutritional Intervention Improves Dm Accompanied With Admentioning

confidence: 99%

Nutritional intervention for diabetes mellitus with Alzheimer's disease

Xiao

et al. 2022

Front. Nutr.

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The combined disease burden of diabetes mellitus (DM) and Alzheimer's disease (AD) is increasing, and the two diseases share some common pathological changes. However, the pharmacotherapeutic approach to this clinical complexity is limited to symptomatic rather than disease-arresting, with the possible exception of metformin. Whether nutritional intervention might extend or synergize with these effects of metformin is of interest. In particular, dietary patterns with an emphasis on dietary diversity shown to affect cognitive function are of growing interest in a range of food cultural settings. This paper presents the association between diabetes and AD. In addition, the cross-cultural nutritional intervention programs with the potential to mitigate both insulin resistance (IR) and hyperglycemia, together with cognitive impairment are also reviewed. Both dietary patterns and nutritional supplementation showed the effects of improving glycemic control and reducing cognitive decline in diabetes associated with AD, but the intervention specificity remained controversial. Multi-nutrient supplements combined with diverse diets may have preventive and therapeutic potential for DM combined with AD, at least as related to the B vitamin group and folate-dependent homocysteine (Hcy). The nutritional intervention has promise in the prevention and management of DM and AD comorbidities, and more clinical studies would be of nutritional scientific merit.

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Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studies

Cited by 17 publications

References 126 publications

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

Hippocampal Estrogen Signaling Mediates Sex Differences in Retroactive Interference

Nutritional intervention for diabetes mellitus with Alzheimer's disease

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