Role of Right Ventricular Dysfunction and Diabetes Mellitus in N-terminal pro-B-type Natriuretic Peptide Response of Patients With Severe Mitral Regurgitation and Heart Failure After MitraClip

Kaneko, Hidehiro; Neuß, Michael; Weissenborn, Jens; Butter, Christian

doi:10.1536/ihj.16-255

Cited by 15 publications

(14 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, both diseases were identified as negative predictors of the functional improvement after MitraClip procedure. Consistent with our results, diabetes mellitus was found to be a determinant of NT-proBNP nonresponse after MitraClip implantation [43]. In a large MitraClip registry study, it was also an independent predictor of 1-year mortality [44].…”

Section: Impact Of Diabetes Mellitus Und Arterial Hypertension On the Outcome Of Mitraclip Implantationsupporting

confidence: 88%

Predictors of functional improvement in the short term after MitraClip implantation in patients with secondary mitral regurgitation

et al. 2020

View full text Add to dashboard Cite

Background and objectivesMitraClip implantation is an established therapy for secondary mitral regurgitation (MR) in high-risk patients and has shown to improve several important outcome parameters such as functional capacity. Patient selection is both challenging and crucial for achieving therapeutic success. This study investigated baseline predictors of functional improvement as it was quantified by the six-minute walk distance (6MWD) after transcatheter mitral valve repair. Methods and resultsWe retrospectively analyzed 79 patients with secondary MR treated with MitraClip implantation at an academic tertiary care center. Before and four weeks after the procedure, all patients underwent comprehensive clinical assessment, six-minute walk tests and echocardiography. 6MWD significantly improved after MitraClip therapy (295 m vs. 265 m, p < 0.001). A linear regression model including seven clinical baseline variables significantly predicted the change in 6MWD (p = 0.002, R 2 = 0.387). Female gender, diabetes mellitus and arterial hypertension were found to be significant negative predictors of 6MWD improvement. At baseline, female patients had significant higher left ventricular ejection fraction (49% vs. 42%, p = 0.019) and lower 6MWD (240 m vs. 288 m, p = 0.034) than male patients. ConclusionMitraClip implantation in secondary MR significantly improves functional capacity in highrisk patients even in the short term of four weeks after the procedure. Female gender, diabetes mellitus and arterial hypertension are baseline predictors of a less favourable functional outcome. While further validation in a larger cohort is recommended, these parameters may improve patient selection for MitraClip therapy.

show abstract

Section: Impact Of Diabetes Mellitus Und Arterial Hypertension On the Outcome Of Mitraclip Implantationsupporting

confidence: 88%

Predictors of functional improvement in the short term after MitraClip implantation in patients with secondary mitral regurgitation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…12) BNP is a biomarker for cardiac dysfunction. 13) It is secreted by the heart in response to excessive stretching of the heart muscle cells and is released as preproBNP, 14) which comprises the biologically active BNP and the inactive metabolite N-proBNP. Researchers have reported that serum NT-proBNP and cTnI increased after prolonged endurance exercise, which is in correspondence with the decline of cardiac contractility; 12,15) how- C: Quantitative analysis of LC3 II immunoreactivity in myocardium (n = 25visuals/group).…”

Section: Discussionmentioning

confidence: 99%

Alterations of Cardiac K<sub>ATP</sub> Channels and Autophagy Contribute in the Late Cardioprotective Phase of Exercise Preconditioning

Wang

et al. 2018

Int. Heart J.

View full text Add to dashboard Cite

The cardiac effects of exercise preconditioning (EP) are well established; however, the mechanisms involving cardiac ATP-sensitive potassium channel (K channel) subunits and autophagy are yet to be fully established. The present work aims to investigate the alterations of cardiac K channel subunits Kir6.2, SUR2A, and autophagy-related LC3 during the late cardioprotective phase of EP against exhaustive exercise-induced myocardial injury. Rats run on treadmill for four running time intervals, each with 10 minutes running and rest. Exhaustive exercise was performed 24 h after EP. Cardiac biomarkers, cTnI and NT-proBNP, along with the histological stain, were served as indicators of myocardial injury. Cardiac K channel subunits Kir6.2 and SUR2A were analyzed in this study, and autophagy was evaluated by LC3. The results revealed that EP reduced the exhaustive exercise-induced high level of serum cTnI and myocardial ischemia/hypoxia; however, it did not reveal any changes in the serum NT-proBNP level or cardiac BNP. Cardiac SUR2A mRNA significantly upregulated during the exhaustive exercise. The high levels of Kir6.2, SUR2A, LC3IIpuncta and LC3II turnover observed after exhaustive exercise were signiﬁcantly mitigated by EP in the late phase. These results suggest that EP alleviates myocardial injury induced by exhaustive exercise through the downregulation of cardiac K channels and autophagy.

show abstract

“…Nevertheless, the field is still not settled due to contrary results in smaller samples [ 34 ]. Heterogeneous comorbidities might explain nonresponse of NT-proBNP after PMVR [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

3D vena contracta area after MitraClip© procedure: precise quantification of residual mitral regurgitation and identification of prognostic information

Dietl

Prieschenk

Eckert

et al. 2018

Cardiovasc Ultrasound

View full text Add to dashboard Cite

Background: Percutaneous mitral valve repair (PMVR) is increasingly performed in patients with severe mitral regurgitation (MR). Post-procedural MR grading is challenging and an unsettled issue. We hypothesised that the direct planimetry of vena contracta area (VCA) by 3D-transoesophageal echocardiography allows quantifying post-procedural MR and implies further prognostic relevance missed by the usual ordinal scale (grade I-IV). Methods: Based on a single-centre PMVR registry containing 102 patients, the association of VCA reduction and patients' functional capacity measured as six-minute walk distance (6 MW) was evaluated. 3D-colour-Doppler datasets were available before, during and 4 weeks after PMVR. Results: Twenty nine patients (age 77.0 ± 5.8 years) with advanced heart failure (75.9% NYHA III/IV) and severe degenerative (34%) or functional (66%) MR were eligible. VCA was reduced in all patients by PMVR (0.99 ± 0.46 cm

show abstract

Role of Right Ventricular Dysfunction and Diabetes Mellitus in N-terminal pro-B-type Natriuretic Peptide Response of Patients With Severe Mitral Regurgitation and Heart Failure After MitraClip

Cited by 15 publications

References 45 publications

Predictors of functional improvement in the short term after MitraClip implantation in patients with secondary mitral regurgitation

Predictors of functional improvement in the short term after MitraClip implantation in patients with secondary mitral regurgitation

Alterations of Cardiac K<sub>ATP</sub> Channels and Autophagy Contribute in the Late Cardioprotective Phase of Exercise Preconditioning

3D vena contracta area after MitraClip© procedure: precise quantification of residual mitral regurgitation and identification of prognostic information

Contact Info

Product

Resources

About