2011
DOI: 10.1136/jclinpath-2011-200264
|View full text |Cite
|
Sign up to set email alerts
|

Role of routine neuropathological examination for determining cause of death in sudden unexpected deaths in infancy (SUDI)

Abstract: Histological neuropathological examination rarely determines the cause of death in SUDI in the absence of macroscopic abnormalities or neurological clinical history. A macroscopically abnormal brain and the presence of a clinical history of possible neurological disease or of inflicted injury are significantly more likely to be associated with significant histological brain abnormalities.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
4
1

Year Published

2013
2013
2021
2021

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 8 publications
(6 citation statements)
references
References 15 publications
1
4
1
Order By: Relevance
“…An additional 21% had neuropathologic findings playing a somewhat influential role in the final formulation of cause and manner. These results stand in contrast to the study of Pryce et al, in which only 6% of SUID cases had gross and/or microscopic neuropathologic findings of importance to the final diagnosis (15). That study differed, however, in important ways from ours.…”
Section: Invited Reviewcontrasting
confidence: 99%
See 1 more Smart Citation
“…An additional 21% had neuropathologic findings playing a somewhat influential role in the final formulation of cause and manner. These results stand in contrast to the study of Pryce et al, in which only 6% of SUID cases had gross and/or microscopic neuropathologic findings of importance to the final diagnosis (15). That study differed, however, in important ways from ours.…”
Section: Invited Reviewcontrasting
confidence: 99%
“…Of note, the range of neuropathologic findings in that study was similar to ours, including meningitis and hydrocephalus. Their concluding points were that a "macroscopically abnormal brain and the presence of a clinical history of possible neurological disease or of inflicted injury are significantly more likely to be associated with significant histological brain abnormalities" (15). While we essentially are in agreement, we demonstrate a higher percentage of cases in which the neuropathologic examination was influential.…”
Section: Invited Reviewsupporting
confidence: 59%
“…These sections are easily achievable, following specific landmarks, such as the superior cerebellar peduncle decussation in the rostral pons, the medial nucleus of the superior olivary complex in the caudal pons and the dorsal accessory of the inferior olivary nucleus in the medulla oblongata. A diagnosis of hypoplasia of a given nucleus has been formulated when it showed a significant decrease in the number of neurons and/or a decreased area [7], compared to the mean values obtained from a group of age-matched controls, previously collected and stored at the Lino Rossi Research Center [8][9][10][11][12]. The morphometric evaluations were quantitatively performed using an Image-Pro Plus Image Analyzer (Media Cybernetics, Silver Spring, MD, USA).…”
Section: Neuropathological Protocolmentioning
confidence: 99%
“…Among SUID cases in which brains were examined by neuropathologists, 38% had abnormalities that could have contributed to death 60 . By contrast, when nonneuropathologists were primarily involved in brain examinations, only 6% had findings that contributed to death 61 . This suggests that brain findings implicating seizures as a COD are underrecognized when examinations are performed by nonexperts.…”
Section: Sudden Unexpected Infant Deathmentioning
confidence: 99%
“…60 By contrast, when nonneuropathologists were primarily involved in brain examinations, only 6% had findings that contributed to death. 61 This suggests that brain findings implicating seizures as a COD are underrecognized when examinations are performed by nonexperts. Seizures in infancy are often atypical and more difficult to diagnose.…”
Section: Sudden Unexpected Infant Deathmentioning
confidence: 99%