Role of saposin <scp>C</scp> and <scp>D</scp> in auditory and vestibular function

Lustig, Lawrence R.; Alemi, Sean; Sun, Ying; Grabowski, Gregory A.; Akil, Omar

doi:10.1002/lary.25479

Cited by 1 publication

(1 citation statement)

References 36 publications

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“…Antiarrhythmic drugs impair endosomal trafficking, cause lysosomal impairment and affect autophagy pathways (29,30). Vestibular end organ impairment without changes in the auditory system due to lysosomal impairment have been related to defects in saposin C and D function (31).…”

Section: Discussionmentioning

confidence: 99%

A Possible Mechanism for Flecainide Induced Dizziness

Garaycochea

Garcia

Manrique-Huarte

et al. 2022

Otology &Amp; Neurotology

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Objective:Flecainide is an oral class IC antiarrhythmic drug whose most common extracardiac adverse reactions are “dizziness” and “visual disturbances.” We describe a case of flecainide associated- bilateral vestibulopathy and a literature review of this drug's effect on the vestibular system.Patient:Sixty-nine-year-old man with a 3-month history of unsteadiness and dizziness after an increase in the dose of flecainide.Interventions:Otologic examination, video head-impulse test, vestibular evoked myogenic potentials, pure tone audiometry and high-resolution magnetic resonance imaging.Results:Otologic examination, including the head-impulse test, and vestibular testing revealed bilateral vestibulopathy.Conclusions:Dizziness is a common extracardiac adverse reaction of Flecainide. Based on the clinical case that we present and the literature review carried out, we hypothesized that a possible mechanism by which flecainide might cause dizziness and visual disturbances is bilateral vestibulopathy.

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Section: Discussionmentioning

confidence: 99%