Role of sarcopenia on survival and treatment-related toxicity in head and neck cancer: a narrative review of current evidence and future perspectives

Erul, Enes; Güven, Deniz Can; Onur, Mehmet Ruhi; Yazıcı, Gözde; Aksoy, Sercan

doi:10.1007/s00405-023-08014-9

Cited by 17 publications

(2 citation statements)

References 131 publications

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“…In addition to skeletal muscle, various body components, such as visceral fat, have been recognized as significant contributors to adverse clinical outcomes in ASCVD patients [43,44]. Future studies that include additional body composition parameters may offer opportunities to evaluate muscle quality, specifically by focusing on myosteatosis [45,46]. This approach may lead to a more comprehensive understanding of the mechanistic interplay between sarcopenia and cardiometabolic risk.…”

Section: Limitation and Future Perspectivesmentioning

confidence: 99%

Quantitative Association between Computed-Tomography-Based L1 Skeletal Muscle Indices and Major Adverse Clinical Events Following Percutaneous Coronary Intervention

Park,

Kang

et al. 2023

JCM

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Sarcopenia is as a non-traditional risk factor for atherosclerotic cardiovascular disease. Further investigation is required to elucidate the prognostic significance of computed tomography (CT)-based sarcopenia assessment in coronary artery disease (CAD). We prospectively enrolled 475 patients, who underwent coronary stent implantation and peri-procedural CT scans within one month. Skeletal muscle index (SMI) was assessed cross-sectionally at the first lumbar vertebra (L1) level. The participants were grouped based on sex-specific L1 SMI quartiles. The primary endpoint was all-cause mortality, and the secondary composite endpoint was major adverse cardiovascular events (MACEs) over a 3-year follow-up period. Three-year all-cause mortality and MACE incidence increased significantly in patients in the lower L1 SMI quartiles compared to those of patients in the higher quartiles (p < 0.001). The individual composite endpoints consistently showed a higher incidence in the lower quartiles of L1 SMI (p < 0.001). In multivariable analysis, the lower L1 SMI quartiles independently predicted 3-year all-cause mortality and MACEs (lowest vs. highest quartiles, respectively: OR 4.90 (95% CI 1.54–15.5), p = 0.007; and OR 12.3 (95% CI 4.99–30.4), p < 0.001). In conclusion, CT-based L1 SMI demonstrated a distinct dose-dependent relationship with future MACEs in CAD patients undergoing percutaneous coronary intervention, thereby enhancing cardiovascular risk stratification.

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Section: Limitation and Future Perspectivesmentioning

confidence: 99%

Quantitative Association between Computed-Tomography-Based L1 Skeletal Muscle Indices and Major Adverse Clinical Events Following Percutaneous Coronary Intervention

Park,

Kang

et al. 2023

JCM

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“…The European Working Group on Sarcopenia in the Elderly (EWGSOP), associate sarcopenia with declining muscle mass and impairment of muscle function (strength or performance) (7). A frequently observed condition in older adults, sarcopenia has been consistently linked with a more unfavorable prognosis across diverse cancers, including head and neck, colorectal, and breast cancers (8)(9)(10)(11)(12). Meyer et al found that sarcopenia was a prognostic marker for survival in gastric cancer undergoing palliative chemotherapy (13).…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia as a prognostic indicator in colorectal cancer: an updated meta-analysis

He,

Luo,

Huang

et al. 2023

Front. Oncol.

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BackgroundSarcopenia, often observed in the elderly, is associated with declining skeletal muscle mass and impaired muscle function. This condition has been consistently linked to a less favorable prognosis in various malignancies. Computed tomography (CT) is a frequently employed modality for evaluating skeletal muscle mass, enabling the measurement of the skeletal muscle index (SMI) at the third lumbar vertebra (L3) level. This measurement serves as a defining criterion for sarcopenia. The meta-analysis dealt with evaluating the promise sarcopenia held as a prognostic indicator in individuals with colorectal cancer.MethodsResearch relevant to the subject was determined by systematically searching PubMed, Embase, Web of Science, WANFANG, and CNKI (up to June 11, 2023, published studies). In this meta-analysis, the incidence of sarcopenia in individuals with colorectal cancer was combined to analyze the disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) of these individuals with and without sarcopenia. The included research was evaluated for quality per the Newcastle-Ottawa Scale (NOS) score. In the multivariate analysis of each study, the direct extraction of hazard ratio (HR) with a 95% confidence interval (CI) was executed. STATA 11.0 was applied to integrate and statistically analyze the data.ResultsOverall 20 articles participated in this meta-analysis. A 34% incidence of sarcopenia was noted in colorectal cancer. The presence of sarcopenia denoted a decrease in OS (HR=1.72,95% CI=1.45-2.03), DFS (HR=1.42,95% CI=1.26-1.60) and CSS (HR=1.48,95% CI=1.26-1.75) in individuals with colorectal cancer. In addition, the subgroup analysis depicted a pattern consistent with the overall analysis results.ConclusionCT-defined sarcopenia exhibits promise as an indicator of survival prognosis in individuals with colorectal cancer. Future studies need a more rigorous definition of sarcopenia to further verify these findings.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023431435.

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The role of the microbiome in head and neck squamous cell cancers

Sahin,

Sonmezer

2024

Eur Arch Otorhinolaryngol

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Role of sarcopenia on survival and treatment-related toxicity in head and neck cancer: a narrative review of current evidence and future perspectives

Cited by 17 publications

References 131 publications

Quantitative Association between Computed-Tomography-Based L1 Skeletal Muscle Indices and Major Adverse Clinical Events Following Percutaneous Coronary Intervention

Quantitative Association between Computed-Tomography-Based L1 Skeletal Muscle Indices and Major Adverse Clinical Events Following Percutaneous Coronary Intervention

Sarcopenia as a prognostic indicator in colorectal cancer: an updated meta-analysis

The role of the microbiome in head and neck squamous cell cancers

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