Role of Scaffolds in the Reconstruction of Anterior Cruciate
Ligament of Knee-Systematic Review

Nellaiyappan, Balasubramanian; Karuppaiah, Karthik

doi:10.17554/j.issn.2311-5106.2016.03.108

Cited by 1 publication

(3 citation statements)

References 35 publications

(77 reference statements)

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“…142 Early studies reported adverse events like rerupture, tunnel enlargement, and synovitis for Leeds-Keio scaffolds. 130 However, a recent 5 year follow-up study by Ghalayini et al 143 showed promising results in ACL reconstruction.…”

Section: Signaling Strategies In Biodegradable Scaffoldsmentioning

confidence: 99%

“…Various materials have been used for clinical trials of TL repair, most of which are commercially available synthetic (absorbable and nonabsorbable) scaffolds. − Current technologies build on decades of basic research on materials and scaffold design. Indeed, the first artificial ligament was implanted over 100 years ago in 1918 by creating a graft from silk sutures .…”

Section: Clinical Trialsmentioning

confidence: 99%

“…Leeds-Keio (i.e., Poly-Tape) is also made of knitted/weaved PET fibers and is designed for ACL reconstruction with a similar stiffness (200 N/mm) to native ACL . Early studies reported adverse events like rerupture, tunnel enlargement, and synovitis for Leeds-Keio scaffolds . However, a recent 5 year follow-up study by Ghalayini et al showed promising results in ACL reconstruction.…”

Section: Clinical Trialsmentioning

confidence: 99%

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Biofabrication and Signaling Strategies for Tendon/Ligament Interfacial Tissue Engineering

Heidari

Ruan

De‐Juan‐Pardo

et al. 2021

ACS Biomater. Sci. Eng.

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Tendons and ligaments (TL) have poor healing capability, and for serious injuries like tears or ruptures, surgical intervention employing autografts or allografts is usually required. Current tissue replacements are nonideal and can lead to future problems such as high retear rates, poor tissue integration, or heterotopic ossification. Alternatively, tissue engineering strategies are being pursued using biodegradable scaffolds. As tendons connect muscle and bone and ligaments attach bones, the interface of TL with other tissues represent complex structures, and this intricacy must be considered in tissue engineered approaches. In this paper, we review recent biofabrication and signaling strategies for biodegradable polymeric scaffolds for TL interfacial tissue engineering. First, we discuss biodegradable polymeric scaffolds based on the fabrication techniques as well as the target tissue application. Next, we consider the effect of signaling factors, including cell culture, growth factors, and biophysical stimulation. Then, we discuss human clinical studies on TL tissue healing using commercial synthetic scaffolds that have occurred over the past decade. Finally, we highlight the challenges and future directions for biodegradable scaffolds in the field of TL and interface tissue engineering.

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Section: Signaling Strategies In Biodegradable Scaffoldsmentioning

confidence: 99%