Role of SCC mec Type in Outcome of Staphylococcus aureus Bacteremia in a Single Medical Center

Abstract

Staphylococcus aureus virulence factors may determine infection presentation. Whether

Methicillin-Resistant <i>Staphylococcus aureus</i> SCC<i>mec</i> Type and Its Association with Clinical Presentation, Severity, and Length of Stay among Patients with Complicated Skin and Skin Structure Infections

“…Although some studies have shown that SCCmec II is associated with a higher mortality rate compared to the other SCCmec types [5], we have previously shown no significant difference between the type of SCCmec and clinical cure and mortality among patients with MRSA cSSTIs [6]. This has also been confirmed by other studies [7] [8].…”

Multiplex Real-Time PCR for Rapid Staphylococcal Cassette Chromosome mec Typing

“…All PCR amplicons in our multiplex platform are Յ174 bp long (Table 1), thereby contributing directly to increased amplification efficiency and sensitivity of detection using minimal reaction volumes, as well as facilitating analysis of low-quality/fragmented DNA. The sensitivity afforded by our method may also allow for SCCmec typing directly from blood cultures (38), which is of potential interest in light of recent reports describing differences in clinical outcome between S. aureus bacteremias associated with particular SCCmec types (19).…”

Predictors of Mortality in Staphylococcus aureus Bacteremia

“…The overall mortality rate from SAB varies depending on the primary focus of infection, with the highest mortality rates occurring in patients with primary bacteremic pulmonary infections (33,39,41,96,206,296,301) and infective endocarditis (IE) (77,168,237,296,301).…”

“…These comorbidities include the presence of alcoholism (131), immunosuppression (131), cirrhosis (133,134,138,140), congestive cardiac failure (171), malignancy (33,77,133,134,140,308,309), chronic renal failure requiring hemodialysis (77,131,134,184), and the presence of multiple comorbidities (14).…”