2023
DOI: 10.1111/odi.14764
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Role of DNA methylation‐based mitotic ageing indices in oral cancer development and recurrence

Srikant Ambatipudi,
Mayuri Inchanalkar,
Manoj B. Mahimkar

Abstract: ObjectiveDNA methylation data can be used to derive mitotic indices from complex tissues. Here, we assessed if the DNA methylation‐derived mitotic ageing indices are associated with oral squamous cell carcinoma (OSCC) development and recurrence‐free survival (RFS).MethodsDNA methylation‐based mitotic indices (MitoticAge, TNSC and hypoSC) were derived using algorithms “MitoticAge” and “epiTOC2” for the discovery [non‐malignant (n = 22), premalignant (n = 22) and OSCC (n = 68) tissues] and validation datasets (G… Show more

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