Role of IL‐13Rα2 in modulating IL‐13‐induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa

Abstract

IL-13Rα2 has a potential role in IL-13-induced MUC5AC and ciliary changes through ERK1/2 signal pathway in the nasal epithelium. IL-13Rα2 may contribute to airway inflammation and aberrant remodeling which are the main pathological features of CRSwNP.

Powder Cellulose in Allergic Rhinitis Management: Relevance of in vitro Findings to Real-Life Safety – Author’s Reply

“…Pointedly, the human nasal epithelial cells (hNECs) which were harvested from surgically resected tissues could be successfully differentiated into various cell types (i.e., ciliated cells, goblet cells) which mostly mimicked the normal human nasal epithelium [4]. In fact, our recent publication has verified that the goblet cell markers (i.e., mucin 5AC) could be readily detected in the air-liquid interface-differentiated hNECs (which were identical to the ones that the current study adopted) and that, in an inflammatory milieu (i.e., chronic rhinosinusitis), the expression of mucin 5AC was significantly augmented and the ciliary disorders also became more prominent [5]. Although our study was not intended to dissect the physiological function of ciliary movement from mucus production, the current experimental model of hNECs remains representative of the physiology of the normal human nasal epithelium.…”

The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium

“…However, because of the overwhelmingly inhibitory effect of IL-13 on BPIFA1 expression in vitro, the genetic impact of rs750064 on BPIFA1 levels was minimal when IL-13 was present. Our selection of the IL-13 dose (10 ng/ml) is extensively used in the literature (14,21,27,28). Nevertheless, it would be interesting to use lower doses of IL-13 in future studies to determine whether the rs750064 CC genotype affects the sensitivity to the suppressing effect of IL-13 on BPIFA1 in airway epithelial cells.…”

Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children

“…Although many potential mechanisms have been suggested [20, 21], the exact cause of the disturbed function of cilia in rhinitis allergy remains unclear. The major effect of inflammatory mediators on mucociliary function may be associated with the Il-13 induced mucociliary beating impairment [22] and with leukotriene D4, which stimulates the ciliary activity simultaneously impairing the cilia in orientation [23]. …”