Role of <scp>microRNAs</scp> in <i>Staphylococcus aureus</i> infection: Potential biomarkers and mechanism

Mirzaei, Rasoul; Mohammadzadeh, Rokhsareh; Mirzaei, Hamed; Sholeh, Mohammad; Karampoor, Sajad; Abdi, Milad; Alikhani, Mohammad Yousef; Kazemi, Sima; Ahmadyousefi, Yaghoub; Jalalifar, Saba; Yousefimashouf, Rasoul

doi:10.1002/iub.2325

Cited by 34 publications

(11 citation statements)

References 111 publications

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“…The body's immune system recognizes the entire virus or its surface epitope once inside the target cells, inducing an immune response (innate or adaptive). 2 , 20 , 41 , 42 When a virus is initially detected, immune cells' pathogen recognition receptors (PRRs), mainly Toll‐like receptors (TLRs) 3, 7, and 8, synthesize more interferon (IFN). 1 , 20 The nonstructural proteins of SARS‐CoV and MERS‐CoV disrupt the activity of host innate immunity, affecting total cytokine generation.…”

Section: Immune Response To Sars‐cov‐2mentioning

confidence: 99%

Role of genetic variants and host polymorphisms on COVID‐19: From viral entrance mechanisms to immunological reactions

Adli

Rahimi

Khodaie

et al. 2022

Journal of Medical Virology

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Coronavirus disease 2019 (COVID‐19), caused by a highly pathogenic emerging virus, is called severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Knowledge regarding the pathogenesis of this virus is in infancy; however, investigation on the pathogenic mechanisms of the SARS‐CoV‐2 is underway. In COVID‐19, one of the most remarkable characteristics is the wide range of disease manifestation and severity seen across individuals of different ethnic backgrounds and geographical locations. To effectively manage COVID‐19 in the populations, beyond SARS‐CoV‐2 detection, serological response assessment, and analytic techniques, it is critical to obtain knowledge about at‐risk individuals and comprehend the identified variations in the disease's severity in general and also in the populations' levels. Several factors can contribute to variation in disease presentation, including population density, gender and age differences, and comorbid circumstances including diabetes mellitus, hypertension, and obesity. Genetic factors presumably influence SARS‐CoV‐2 infection susceptibility. Besides this, COVID‐19 has also been linked with a higher risk of mortality in men and certain ethnic groups, revealing that host genetic characteristics may affect the individual risk of death. Also, genetic variants involved in pathologic processes, including virus entrance into cells, antiviral immunity, and inflammatory response, are not entirely understood. Regarding SARS‐CoV‐2 infection characteristics, the present review suggests that various genetic polymorphisms influence virus pathogenicity and host immunity, which might have significant implications for understanding and interpreting the matter of genetics in SARS‐CoV‐2 pathogenicity and customized integrative medical care based on population investigation.

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Section: Immune Response To Sars‐cov‐2mentioning

confidence: 99%

Role of genetic variants and host polymorphisms on COVID‐19: From viral entrance mechanisms to immunological reactions

Adli

Rahimi

Khodaie

et al. 2022

Journal of Medical Virology

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“…Additionally, clinical infections of Staphylococci are associated with diminished apoptosis of PMNs in diabetic persons, which direct the prolonged formation of TNF-α and thus reduce the bacterial clearance of PMNs (Hanses et al 2011 ; Mirzaei et al 2017 ; Mirzaei et al 2020 e; Rasoul et al 2019 ). PMNs are impressive at killing planktonic bacterial cells; however, bacterial biofilm emerges to resist the microbicidal activities of PMNs, and can even profit from the cellular debris left behind the matrix.…”

Section: Immune Polarizationmentioning

confidence: 99%

Immunometabolism in biofilm infection: lessons from cancer

Mirzaei

Sabokroo

Ahmadyousefi

et al. 2022

Mol Med

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Background Biofilm is a community of bacteria embedded in an extracellular matrix, which can colonize different human cells and tissues and subvert the host immune reactions by preventing immune detection and polarizing the immune reactions towards an anti-inflammatory state, promoting the persistence of biofilm-embedded bacteria in the host. Main body of the manuscript It is now well established that the function of immune cells is ultimately mediated by cellular metabolism. The immune cells are stimulated to regulate their immune functions upon sensing danger signals. Recent studies have determined that immune cells often display distinct metabolic alterations that impair their immune responses when triggered. Such metabolic reprogramming and its physiological implications are well established in cancer situations. In bacterial infections, immuno-metabolic evaluations have primarily focused on macrophages and neutrophils in the planktonic growth mode. Conclusion Based on differences in inflammatory reactions of macrophages and neutrophils in planktonic- versus biofilm-associated bacterial infections, studies must also consider the metabolic functions of immune cells against biofilm infections. The profound characterization of the metabolic and immune cell reactions could offer exciting novel targets for antibiofilm therapy.

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“…The miRNA biogenesis is a regulated mechanism (Figure 1), and its characterization is described in detail in previous studies. [45][46][47] The capacity of miRNA molecules to coordinate precise protein formation during differentiation, proliferation, inflammation, and apoptosis has found their significant activities in the host. [48][49][50] Additionally, miRNA has been seen as new regulators of various pathways contributing to host immune responses, cancer, inflammatory, and autoimmune diseases.…”

Section: Microrna Biogenesis and Rolementioning

confidence: 99%

“…In some cases, it could play a negative feedback agent that influences and regulates immune responses. 47,58…”

Section: Microrna Biogenesis and Rolementioning

confidence: 99%

microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment

Kazemi

Mirzaei

Sholeh

et al. 2021

Immunity Inflam & Disease

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Introduction: Human brucellosis is a zoonotic bacterial disease with up to 500,000 new cases each year. The major evasion mechanisms from the host immune system by Brucella are restraint of complement pathway and Toll-like receptors signaling pathways, interference with efficient antigen presentation to CD4-positive T lymphocytes, selective subversion of autophagy pathways, inhibition of dendritic cell stimulation, inhibition of autophagolysosomal fusion, and macrophage apoptosis. Many molecular and cellular pathways contribute to brucellosis that microRNAs have a vital function in the immunopathogenesis of this disease. In this regard, these molecules apply for their roles by modulating various events like inflammatory reactions and immune defense. Recently, in the case of immunity to human brucellosis, it has been shown that microRNAs play an important role in immunity against these bacteria. Methods and Results:In this study, we tried to review the immune defense and immunopathogenesis of Brucella infection and highlight the current knowledge of the microRNAs in infected cells by Brucella pathogens. The recent findings suggest that the regulation of microRNAs expression is impaired during brucellosis infection, which may contribute to disease progression or inhibition by modulating immune responses against this pathogen. Conclusions:The interplay between miRNAs and Brucella pathogens and the underlying process required comprehensive examination to unravel the novel therapeutic or diagnostic approaches.

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Role of microRNAs in Staphylococcus aureus infection: Potential biomarkers and mechanism

Cited by 34 publications

References 111 publications

Role of genetic variants and host polymorphisms on COVID‐19: From viral entrance mechanisms to immunological reactions

Role of genetic variants and host polymorphisms on COVID‐19: From viral entrance mechanisms to immunological reactions

Immunometabolism in biofilm infection: lessons from cancer

microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment

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