Role of seaweed laminaran from Saccharina longicruris on matrix deposition during dermal tissue-engineered production

Lee

et al. 2018

Preprint

Marine algae have been considered as abundant source of bioactive compounds with cosmeceutical potential. Recently, a great deal of interest has focused on the health-promoting effects of marine bioactive compounds. Carbohydrate is a major and abundant constitute of marine algae that have been utilized in cosmetic formulations, such as moisturizing and thickening agents. In addition, marine carbohydrates have been suggested as promising bioactive biomaterials for various skin beneficial properties, such as anti-oxidant, anti-melanogenic and anti-skin aging. Therefore, marine algae carbohydrates have potential of skin health benefits for value-added cosmeceutical application. The present review focused on the various biological capacities and potential skin health benefits of bioactive marine carbohydrates.

Section: Laminaranmentioning

confidence: 99%

Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

Lee

et al. 2018

Preprint

BioMed Research International

“…Thereby, increased cost over the traditional culture model and large-scale production of the 3D tumor model generated by the self-assembly method could also become a disadvantage. Nevertheless, recent scientific breakthroughs have addressed these limitations using new cell culture protocols aimed at increasing the rate of ECM formation [244,245]. Furthermore, although many questions and hurdles remain, biobanks of patient-derived 3D cancer models should further refine our understanding of interpatient as well as intrapatient heterogeneity, and hopefully, lead to personalized therapies for cancers.…”

Section: Perspectives and Future Directionsmentioning

confidence: 99%

Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors

Roy

Magne

Vaillancourt-Audet

et al. 2020

Self Cite

Cancer research has considerably progressed with the improvement of in vitro study models, helping to understand the key role of the tumor microenvironment in cancer development and progression. Over the last few years, complex 3D human cell culture systems have gained much popularity over in vivo models, as they accurately mimic the tumor microenvironment and allow high-throughput drug screening. Of particular interest, in vitrohuman 3D tissue constructs, produced by the self-assembly method of tissue engineering, have been successfully used to model the tumor microenvironment and now represent a very promising approach to further develop diverse cancer models. In this review, we describe the importance of the tumor microenvironment and present the existing in vitro cancer models generated through the self-assembly method of tissue engineering. Lastly, we highlight the relevance of this approach to mimic various and complex tumors, including basal cell carcinoma, cutaneous neurofibroma, skin melanoma, bladder cancer, and uveal melanoma.

“…Importantly, high glycosaminoglycan and collagen contents were determined in the cells by applying alginate incorporated scaffold [74]. Ayoub et al [75] anticipated that the incorporation of laminaran polysaccharide from a brown seaweed Saccharina longicruris could drive up the matrix deposition and thus accelerate the tissue-generation process. They allowed producing a dermis by culturing monolayer human skin fibroblasts in the presence of seaweed-derived laminaran for 7 or 35 days.…”

Section: Tissue-engineering Aspectsmentioning

confidence: 99%

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

Bilal

Iqbal

2019

Marine Drugs

Seaweed-derived polysaccharides with unique structural and functional entities have gained special research attention in the current medical sector. Seaweed polysaccharides have been or being used to engineer novel cues with biomedical values to tackle in practice the limitations of counterparts which have become ineffective for 21st-century settings. The inherited features of seaweed polysaccharides, such as those of a biologically tunable, biocompatible, biodegradable, renewable, and non-toxic nature, urge researchers to use them to design therapeutically effective, efficient, controlled delivery, patient-compliant, and age-compliant drug delivery platforms. Based on their significant retention capabilities, tunable active units, swelling, and colloidal features, seaweed polysaccharides have appeared as highly useful materials for modulating drug-delivery and tissue-engineering systems. This paper presents a standard methodological approach to review the literature using inclusion-exclusion criteria, which is mostly ignored in the reported literature. Following that, numerous marine-based seaweed polysaccharides are discussed with suitable examples. For the applied perspectives, part of the review is focused on the biomedical values, i.e., targeted drug delivery, wound-curative potential, anticancer potentialities, tissue-engineering aspects, and ultraviolet (UV) protectant potential of seaweed polysaccharides based engineered cues. Finally, current challenges, gaps, and future perspectives have been included in this review.