Role of second messengers in the regulation of juvenile hormone production in insects, with particular emphasis on calcium and phosphoinositide signaling

Rachinsky, Anna; Tobe, Stephen S.

doi:10.1002/(sici)1520-6327(1996)33:3/4<259::aid-arch7>3.0.co;2-n

Cited by 33 publications

(10 citation statements)

References 80 publications

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“…However, it appears that the Na+/K+ ratio does not have a great influence on JH synthesis in this insect species. It has been reported that Ca2+ can function as a second messenger in regulating JH synthesis (reviewed by Rachinsky & Tobe, 1996). When CA from S. gregaria (Thompson & Tobe, 1986), M. sexta (Allen et al, 1992), and cockroach Diplopterapunctata (Kikukawa et al, 1987) were incubated in the absence of Ca2+, little or no JH was synthesized.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Ca2+ can act as a second messenger controlling JH synthesis. This means that the Ca2+ concentration in the medium will also affect JH synthesis (reviewed by Rachinsky & Tobe, 1996). Using the suggested incubation conditions for CA of the beetle Coccinella septempunctata (Guan & Chen, 1986), it was found that the rate of JH synthesis in vitro by CA from newly emerged female adult Eri silkworm Samia cynthia ricini was extremely low.…”

Section: Introductionmentioning

confidence: 99%

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Developmental changes in the ability to synthesize juvenile hormone in vitro by corpora allata from the Eri silkworm, Samia cynthia ricini (Lepidoptera: Saturniidae)

Sheng¹,

Jiang²,

Cao³

2002

Eur. J. Entomol.

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Abstract. A radiochemical assay (RCA) has been used for the measurement ofjuvenile hormone (JH) synthesis in vitro by corpora allata (CA) from the Eri silkworm, Samia cynthia ricini. Using CA from newly emerged female adults for the bioassay, the most suitable incubation conditions were determined. A high rate of JH synthesis was found in medium TC199 at pH 6.5, 30°C and 4 mM Ca2+. The time course of JH synthesis showed a steady decrease during the first 6 hours of incubation.Under optimal incubation conditions, CA from the 4th and 5th larval instars, pupae and adults were used for measuring JH syn thesis in vitro. The highest rates of JH synthesis were found on the 1st day of both larval stages, and then JH synthesis decreased steadily during the following two days of each instar. From the 4th day of the 5th larval instar to the 2nd day after pupation, CA could still synthesize small amounts of JH. However, from the 3rd day of the pupal stage to 12 hours before adult emergence, no JH release was observed. About 6 hours before emergence, CA of both female and male pharate adults regained the ability to synthe size JH. JH synthesis increased to a maximum shortly after emergence and then decreased again during the following two days. During this period, JH synthesis in vitro by CA from females was always higher than that of males. This is the first report on JH syn thesis in vitro by CA from both female and male pharate adults and adults of a lepidopteran species, where the adults do not feed, are relatively short-lived, mate only once, and ovarian maturation and vitellogenesis are completed before emergence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Developmental changes in the ability to synthesize juvenile hormone in vitro by corpora allata from the Eri silkworm, Samia cynthia ricini (Lepidoptera: Saturniidae)

Sheng¹,

Jiang²,

Cao³

2002

Eur. J. Entomol.

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“…The role of calcium in regulating CA activity is well documented (Rachinsky and Tobe, 1996), and its importance is underscored by the identification of a calmodulin EST as well as by ESTs for homologs of presenilin in both cockroach and mosquito.…”

Section: Regulation Of Jh Biosynthesismentioning

confidence: 99%

Comparative genomics of insect juvenile hormone biosynthesis☆

Noriega

Ribeiro

Koener

et al. 2006

Insect Biochemistry and Molecular Biology

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The biosynthesis of insect juvenile hormone (JH) and its neuroendocrine control are attractive targets for chemical control of insect pests and vectors of disease. To facilitate the molecular study of JH biosynthesis, we analyzed ESTs from the glands producing JH, the corpora allata (CA) in the cockroach Diploptera punctata, an insect long used as a physiological model species and compared them with ESTs from the CA of the mosquitoes Aedes aegypti and Anopheles albimanus. The predicted genes were analyzed according to their probable functions with the Gene Ontology classification, and compared to Drosophila and Anopheles gambiae genes. A large number of reciprocal matches in the cDNA libraries of cockroach and mosquito CA were found. These matches defined known and suspected enzymes of the JH biosynthetic pathway, but also several proteins associated with signal transduction that might play a role in the modulation of JH synthesis by neuropeptides. The identification in both cockroach and mosquito CA of homologs of the small ligand binding proteins from insects, Takeout/JH binding protein and retinol-binding protein highlights a hitherto unsuspected complexity of metabolite trafficking, perhaps JH precursor trafficking, in these endocrine glands. Furthermore, many reciprocal matches for genes of unknown function may provide a fertile ground for an in-depth study of allatal-specific cell physiology.

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“…Their primary function in reproduction is to initiate vitellogenin synthesis in the fat body and to regulate the uptake of yolk by the ovary (Hoffmann, 1995). JH biosynthesis is a tightly regulated process involving stimulating (allatotropins) and inhibiting (allatostatins) neuropetides secreted by brain neurosecretory cells (Kataoka et al, 1989;Stay and Tobe, 2007), and also classical neurotransmitters (Chiang et al, 2002a;Granger et al, 2000;Liu et al, 2005;Rachinsky and Tobe, 1996).…”

Section: Introductionmentioning

confidence: 99%

Effects of the NMDA receptor antagonist MK-801 on female reproduction and juvenile hormone biosynthesis in the cricketGryllus bimaculatusand the butterflyBicyclus anynana

Geister

Lorenz

Hoffmann

et al. 2008

Journal of Experimental Biology

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SUMMARYApart from regulating insect development, juvenile hormones (JHs) play an important role in insect reproduction, where they initiate vitellogenin synthesis and regulate the uptake of yolk by the ovary. JH synthesis is a tightly regulated process controlled by neurons and peptidergic neurosecretory cells. One of the known stimulatory regulators of JH biosynthesis is glutamate, and its N-methyl-D-aspartate (NMDA) receptor has been recently found in the cockroach Diploptera punctata. In this study we demonstrate a strong reduction in reproductive output in the tropical butterfly Bicyclus anynana and the Mediterranean field cricket Gryllus bimaculatus caused by the NMDA receptor antagonist MK-801. Such inhibiting effects on reproduction could be overruled by the application of JH mimics. In G. bimaculatus, MK-801 inhibits in vitro JH biosynthesis in the corpora allata and reduces in vivo JH haemolymph titres in a dose-dependent manner. These results suggest that JH biosynthesis in the corpora allata is at least in part controlled by an NMDA receptor with Ca 2+ as a second level messenger. Based on our findings we consider NMDA receptor antagonists as important tools for manipulating juvenile hormone biosynthesis and therefore for gaining a better understanding of the mechanistic basis of reproduction.

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Role of second messengers in the regulation of juvenile hormone production in insects, with particular emphasis on calcium and phosphoinositide signaling

Cited by 33 publications

References 80 publications

Developmental changes in the ability to synthesize juvenile hormone in vitro by corpora allata from the Eri silkworm, Samia cynthia ricini (Lepidoptera: Saturniidae)

Developmental changes in the ability to synthesize juvenile hormone in vitro by corpora allata from the Eri silkworm, Samia cynthia ricini (Lepidoptera: Saturniidae)

Comparative genomics of insect juvenile hormone biosynthesis☆

Effects of the NMDA receptor antagonist MK-801 on female reproduction and juvenile hormone biosynthesis in the cricketGryllus bimaculatusand the butterflyBicyclus anynana

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