Role of second‐trimester uterine artery Doppler indices in the prediction of adverse pregnancy outcomes in a low‐risk population

Adefisan, Adeyemi Sunday; Akintayo, Akinyemi A.; Awoleke, Jacob Olumuyiwa; Awolowo, Anthony T.; Aduloju, Olusola Peter

doi:10.1002/ijgo.13302

Cited by 8 publications

(7 citation statements)

References 23 publications

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“…While the UAPI above the 95th percentile had a high specificity for predicting preeclampsia, it had a low sensitivity. The findings were consistent with previous studies 34 , 35 . From the previous meta-analysis, Cnossen et al found that an increased UAPI with notching was the best predictor of preeclampsia (positive likelihood ratio 7.5 among low-risk patients).…”

Section: Discussionsupporting

confidence: 94%

Second-trimester serum high mobility group box-1 and uterine artery Doppler to predict preeclampsia

Wairachpanich

Phupong

2022

Sci Rep

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The objective of this study was to identify the predictive value for preeclampsia of second-trimester serum high mobility group box-1 (HMGB1) and uterine artery Doppler in singleton pregnancies. Between April 2020 and April 2021, a prospective study was conducted on singleton pregnancies with a gestational age of 16–20+6 weeks at King Chulalongkorn Memorial Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Maternal characteristics, uterine artery Doppler, and serum HMGB1 were collected. Serum HMGB1 levels and mean uterine artery pulsatility index (UAPI) were combined to calculate the predictive value for preeclampsia. A total of 393 pregnant women were analyzed, with 25 cases (6.4%) developing preeclampsia and 5 cases (1.3%) developing early-onset preeclampsia. Baseline characteristics of preeclampsia and normal pregnant women were comparable. Preeclamptic pregnant women had significantly higher mean serum HMGB1 levels than normal pregnant women (1112.8 ± 363.1 ng/mL vs 910.8 ± 486.1 ng/mL, p = 0.013). There was no difference in the mean UAPI. Any early-diastolic notching was found more frequently in the preeclampsia group (32.0% vs 12.5%, p = 0.013). The cut-off value for serum HMGB1 levels above 1.04 MoM as abnormal value to predict preeclampsia had sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 88.0%, 53.5%, 11.4% and 98.5%, respectively. When using abnormal serum HMGB1 levels combined with mean UAPI above 95th percentile, the sensitivity, specificity, PPV and NPV to predict preeclampsia were 88.0%, 50.8%, 10.8% and 98.4%, respectively. This study showed that serum HMGB1 at 16–20+6 weeks of gestation were effective in predicting preeclampsia. The addition of UAPI did not improve the prediction performance.

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Section: Discussionsupporting

confidence: 94%

Second-trimester serum high mobility group box-1 and uterine artery Doppler to predict preeclampsia

Wairachpanich

Phupong

2022

Sci Rep

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“…In the current study, mean BMI was 25.83±2.2 with ranged from 19.84 to 29.62, the mean of systolic blood pressure was 124±14.2 with range from 105 to 170 and diastolic blood pressure, 76±11.43; with range from 60 to 110. This came in agreement with Adefisan et al (13) who found that mean BMI was 26.39, SBP was 112.4, DBP was 68.9. Gomez et al (12) found that mean BMI was 23.9.…”

Section: Discussionsupporting

confidence: 92%

“…This came in agreement with Gomez et al (12) who found that mean age was 30.5 years old. Also, Adefisan et al (13) found that mean age was 30.12 years old.…”

Section: Discussionmentioning

confidence: 95%

“…This came in agreement with Gomez et al (12) who found that the most prevailing Maternal adverse outcome was preeclampsia. Adefisan et al (13) found that 20.0% had pre-eclampsia, 18.0% had pregnancyinduced hypertension without proteinuria, 26.0% had IUGR, 50.0% had low birthweight neonates, and 6.0% women experienced stillbirth. Fetal growth restriction (FGR) that develops in the absence of preeclampsia may also have its origin in defective placentation (14) .…”

Section: Discussionmentioning

confidence: 99%

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Predicting Adverse Pregnancy Outcomes During the Late First Trimester and Early Second Trimester Using the Uterine Artery Doppler

Wahid¹,

Mahdy²,

Mowafy³

et al. 2021

The Egyptian Journal of Hospital Medicine

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“…The Doppler examination's noninvasive nature could render it an effective screening tool for the prediction of negative pregnancy results in otherwise low-risk patients. 4 Doppler ultrasound is an extremely useful technique for managing high-risk pregnancies. By contrasting diastolic and systolic waveforms, direct evaluation of trophoblast invasion allows noninvasive assessment of the uteroplacental circulation.…”

Section: Introductionmentioning

confidence: 99%

Uses of the color Doppler of the uterine arteries in the early second trimester for prediction of the intrauterine growth restriction

Ouda

Mohamed²,

Elboghdady³

2022

Al-Azhar International Medical Journal

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Background:The introduction of sonography altered obstetrics practice by offering a window through which the fetus's anatomic structure could be assessed. Many investigations have found a link between second trimester uterine artery Doppler pulsatility and resistance indices (PI and RI) and the development of intrauterine growth restriction. There is an indication; however, that trophoblast invasion is greatest during the first trimester, when uterine artery blood flow can also be evaluated with a Doppler. Aim of the work:To investigate the role of uterine artery Doppler in the prediction of intrauterine growth restriction during the early second trimester. Patients and methods: A cross-sectional observational study on 100 pregnant women attending the Obstetric and Gynecology Outpatient clinic at Al-Azhar University Hospitals was done. A Doppler analysis of uterine artery flow velocimetry waveforms utilizing a continuous wave type was done. The results of the PI and the RI were registered and standard deviations were estimated. Results: Uterine PI achieved significance for predicting IUGR at cutoff point ≥1.63 with sensitivity of 83% and specificity of 91.6% with PPV 54% and NPV 88%. While, uterine RI achieved significance for predicting IUGR at cutoff point ≥0.67 with sensitivity of 71.8% and specificity of 87.2% with PPV 47% and NPV 82%. Conclusion: Abnormal UtA Doppler ultrasonography (elevated PI) in second trimester can predict IUGR among women with high risk factors which can be enhanced by biochemical tests.

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Role of second‐trimester uterine artery Doppler indices in the prediction of adverse pregnancy outcomes in a low‐risk population

Abstract: Objective: To evaluate use of second-trimester uterine artery Doppler velocimetry to predict adverse pregnancy outcomes. Methods: A prospective longitudinal study among low-risk nulliparous women with singleton pregnancies attending

Cited by 8 publications

References 23 publications

Second-trimester serum high mobility group box-1 and uterine artery Doppler to predict preeclampsia

Second-trimester serum high mobility group box-1 and uterine artery Doppler to predict preeclampsia

Predicting Adverse Pregnancy Outcomes During the Late First Trimester and Early Second Trimester Using the Uterine Artery Doppler

Uses of the color Doppler of the uterine arteries in the early second trimester for prediction of the intrauterine growth restriction

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