2012
DOI: 10.2741/3962
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Role of secreted factors in the regulation of hematopoietic stem cells by the bone marrow microenvironment

Abstract: The stem cell microenvironment (in vivo known as niche) is a specific space in the bone marrow (BM), which nurses hematopoietic stem cells and regulates their self-renewal and differentiation using extrinsic cues, such as secreted factors. The niche plays a major role in regulating the number of blood cells and also protects stem cells against excessive proliferation. Till date, several possible secreted regulators of HSC function have been reported. Many of these were originally isolated from stromal cells an… Show more

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Cited by 7 publications
(8 citation statements)
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References 119 publications
(72 reference statements)
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“…HSCs reside in the BM, proximal to the BM stromal cells, and this is considered to be their niche in a broad sense . This niche comprises non‐haematopoietic cells such as fibroblasts, reticular cells, endothelial cells, adipocytes and osteoblasts that provide soluble factors and extracellular matrix to support the expansion and activity of HSCs, but the exact location and the definition of the HSC niche still remains controversial. Previous studies have shown HSCs both located near the endosteal region (closer to the osteoblasts) or in perivascular regions near the reticular cells that express high levels of chemokine C‐X‐C motif ligand 12 (CXCL12) .…”
Section: Interactions Between Parenchymal Tissues and Mscs In Tissue mentioning
confidence: 99%
“…HSCs reside in the BM, proximal to the BM stromal cells, and this is considered to be their niche in a broad sense . This niche comprises non‐haematopoietic cells such as fibroblasts, reticular cells, endothelial cells, adipocytes and osteoblasts that provide soluble factors and extracellular matrix to support the expansion and activity of HSCs, but the exact location and the definition of the HSC niche still remains controversial. Previous studies have shown HSCs both located near the endosteal region (closer to the osteoblasts) or in perivascular regions near the reticular cells that express high levels of chemokine C‐X‐C motif ligand 12 (CXCL12) .…”
Section: Interactions Between Parenchymal Tissues and Mscs In Tissue mentioning
confidence: 99%
“…Because incompatible genes were prone to distribution on the plasma membrane or outside of the cell (Figure 3B and C), we collected and summarized the key extracellular signaling molecules and their receptor genes taking vital roles in HSPCs’ homing, maintenance, and differentiation process (Figure 7C). 41,42,44 Among HPSC homing‐associated genes, integrin alpha 4 (ITGA4) exhibited remarkably low similarity and different domain compositions between humans and pigs. According to Ensembl, the InterProScan database failed to predict hITGA4 protein domains or functional sites, but it correctly predicted that pITGA4 has two FG‐GAP repeat domains and one Integrin alpha domain (Figure 7D).…”
Section: Resultsmentioning
confidence: 99%
“…In this review, we discuss selected cell types in detail, and although many molecules contribute to crosstalk between the cellular elements of the niche (selected reviews Canaani, Kollet, & Lapidot, 2011;Fecteau & Kipps, 2012;Kaur-Bollinger, Gotze, & Oostendorp, 2012;Park, Sykes, & Scadden, 2012;Schraufstatter, Discipio, & Khaldoyanidi, 2011), this review is focused on hyaluronan (HA). Understanding how stem cells respond to specific microenvironments (healthy or diseased niches or sites of stem cell transplantation) is critical for the effective treatment of cancer and the development of stem cell-based therapies.…”
Section: The Bm Stem Cell Microenvironmentmentioning
confidence: 99%
“…A critical role for BM macrophages in maintaining and regulating the hematopoietic microenvironment was first postulated in the 1980s (Lichtman, 1981;Weiss, 1980Weiss, , 1981, but further studies were neglected for at least a decade after the role of osteoblasts was proposed (Taichman & Emerson, 1994). The ability of macrophages to respond to HA stimulation is a topic of great interest because, in addition to other important functions in BM, macrophages produce soluble factors that are critically involved in homeostasis of the hematopoietic microenvironment (Kaur-Bollinger et al, 2012). Subsequent studies have shown that BM macrophages are required to maintain osteoblasts (Chang et al, 2008) and work performed during recent years has further strengthened the evidence that macrophages play a critical role in structuring the hematopoietic niche (reviewed in Ehninger & Trumpp, 2011).…”
Section: Role Of Macrophages In Bmmentioning
confidence: 99%