Role of secukinumab in ankylosing spondylitis with tubercular uveitis

Mahendradas, Padmamalini; Jain, Vikramraj K; Thomas, Sumi; Kawali, Ankush; Sanjay, Srinivasan; Shetty, Bhujang

doi:10.4103/ijo.ijo_1081_20

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Operative intervention in the form of a hip endoprosthesis should be considered for patients experiencing severe pain, disability, and joint destruction. [1,12,13,14,15,16,17,18,19,20] Monitoring Disease monitoring involves evaluating disease activity, function, and structural changes.…”

Section: Most Commonly a Tnf Inhibitor Or Il-17 Inhibitor Is Usedmentioning

confidence: 99%

Ankylosing Spondylitis: Review of Clinical Features, Diagnosis, and Treatment

Markowiak,

Wardęszkiewicz,

Jabłońska

et al. 2024

J Educ Health Sport

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Introduction Ankylosing spondylitis (AS) is a chronic inflammatory disorder affecting the spine and joints, leading to significant physical impairment. With a prevalence of 0.1-1.4%, AS holds significance in healthcare and socioeconomic contexts, therefore a thorough understanding is crucial for diagnosis and effective management. This article provides a current state of knowledge of the subject for clinicians and patients. Review methods English-language scientific literature found in PubMed, Web of Science, Google Scholar and Wiley databases (2015-2023) was used for the review. Articles were searched based on keywords. Each article was analysed for knowledge currency and relevance for use in the review. Description of the State of Knowledge After searching the articles, 20 articles were selected for final analysis. The data collected provides the latest information on ankylosing spondylitis.The etiology of AS has a strong association with the HLA-B27 antigen and research is being conducted on the association with HLA-15, IL-1, IL-23R, ERAP-1 and ERAP-2. Clinical manifestations include a broad spectrum of symptoms involving the musculoskeletal, ocular, respiratory, cardiovascular, gastrointestinal and psychiatric systems. Specific diagnostic guidelines have been published by ASAS and EULAR. Treatment includes NSAID, GCS and biologic drug therapy. Summary AS, with its complex etiology and diverse clinical manifestations, presents a diagnostic challenge to clinicians. The variable prognosis and complex treatment in AS requires physicians to continually update their knowledge.Early diagnosis and treatment initiation can improve the patient's prognosis.

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Section: Most Commonly a Tnf Inhibitor Or Il-17 Inhibitor Is Usedmentioning

confidence: 99%

Ankylosing Spondylitis: Review of Clinical Features, Diagnosis, and Treatment

Markowiak,

Wardęszkiewicz,

Jabłońska

et al. 2024

J Educ Health Sport

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“…[ 93 ] Autoimmune diseases with superimposed tuberculosis have been managed with secukinumab. [ 94 ] JAK inhibitors (Tofacitinib) have been successful in managing noninfectious uveitis and scleritis. [ 95 ] These targeted therapies are used as corticosteroid-sparing agents to facilitate the complete withdrawal of steroids.…”

Section: Advancements In Uveitis Managementmentioning

confidence: 99%

Evolution of research in diagnosis and management of uveitis over four decades in India

Biswas,

Jadhav,

Eswaran

2024

Indian Journal of Ophthalmology

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Uveitis and its complications are more common in the developing world, in which the condition occurs in up to 714 per 100,000 in the population and accounts for up to 25% of all blindness. In India, the ophthalmic sub speciality of uveitis greatly evolved in the last four decades. In the early decades most of the studies were epidemiological studies. In recent years, more research has been published due to tremendous advancements in clinical diagnosis, laboratory investigations and ancillary test and treatment modalities. In this review article, we did a medline search with key words ‘uveitis’ and ‘India’, and selectively incorporated articles showing the evolution of this sub-speciality in India.

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Immunosuppressants

2021

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Role of secukinumab in ankylosing spondylitis with tubercular uveitis

Cited by 3 publications

References 8 publications

Ankylosing Spondylitis: Review of Clinical Features, Diagnosis, and Treatment

Ankylosing Spondylitis: Review of Clinical Features, Diagnosis, and Treatment

Evolution of research in diagnosis and management of uveitis over four decades in India

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