Role of Semantic Paradigms for Optimization of Language Mapping in Clinical fMRI Studies

Abstract

BACKGROUND AND PURPOSE:The optimal paradigm choice for language mapping in clinical fMRI studies is challenging due to the variability in activation among different paradigms, the contribution to activation of cognitive processes other than language, and the difficulties in monitoring patient performance. In this study, we compared language localization and lateralization between 2 commonly used clinical language paradigms and 3 newly designed dual-choice semantic paradigms to define a streamlined and adequate language-mapping protocol.

Neural correlates of verb and noun processing: An fMRI study of Persian

“…A cued, covert sentence completion task was employed in this study (for relevant studies which used a similar task see Abel, Maguire, Naqvi, & Kim, 2014;Yu, Bi, Han, & Law, 2013;Zaca, Jarso, & Pillai, 2013). A cue phrase, 7 written above the picture, was simultaneously presented with the object or action picture, and the participants were required to covertly produce the singular form of the object and progressive present form of the action within the cue phrase context.…”

Resting-State Seed-Based Analysis: An Alternative to Task-Based Language fMRI and Its Laterality Index

“…Many studies have illustrated that fMRI is a noninvasive imaging technique that facilitates the lateralization of language function in individual patients. [1][2][3] The hemispheric language laterality index (LI) is estimated by evaluating the asymmetry in the activation of language areas in the right and left hemispheres of the human brain during a particular task. 4 The ease of integrating fMRI with other MR imaging techniques allows the correct identification of pathology and its landmark with respect to language areas.…”

Improving Clinical fMRI: Better Paradigms or Higher Field Strength?

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