Role of septum and preoptic area in regulating masculine and feminine sexual behavior in male rats

Kondo, Yasuhiko; Shinoda, Akira; Yamanouchi, Korehito; Arai, Yasumasa

doi:10.1016/0018-506x(90)90019-t

Cited by 122 publications

(64 citation statements)

References 39 publications

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“…These similarities in birds and mammals include sex differences in the response to copulation; thus the POA is more responsive in males whereas the VMH is more responsive in females. Finally, the IEG findings are well corroborated by lesion data on the neural substrates of appetitive and consummatory sexual behavior, as well as aggression (Kondo et al, 1990;Liu et al, 1997;Balthazart et al, 1998;Thompson et al, 1998;Goodson et al, 1999;Riters and Ball, 1999;Absil et al, 2002).…”

Section: The Social Behavior Network In a Vocalizing Fishsupporting

confidence: 64%

The vertebrate social behavior network: Evolutionary themes and variations

Goodson

2005

Hormones and Behavior

719

647

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Based on a wide variety of data, it is now clear that the brains of birds and teleost (bony) fish possess a core "social behavior network" within the basal forebrain and midbrain that is homologous to the social behavior network of mammals. The nodes of this network are reciprocally connected, contain receptors for sex steroid hormones, and are involved in multiple forms of social behavior. Other hodological features and neuropeptide distributions are likewise very similar across taxa. This evolutionary conservation represents a boon for experiments on phenotypic behavioral variation, as the extraordinary social diversity of teleost fish and songbirds can now be used to generate broadly relevant insights into issues of brain function that are not particularly tractable in other vertebrate groups. Two such lines of research are presented here, each of which addresses functional variation within the network as it relates to divergent patterns of social behavior. In the first set of experiments, we have used a sexually polymorphic fish to demonstrate that natural selection can operate independently on hypothalamic neuroendocrine functions that are relevant for 1) gonadal regulation and 2) sex-typical behavioral modulation. In the second set of experiments, we have exploited the diversity of avian social organizations and ecologies to isolate species-typical group size as a quasiindependent variable. These experiments have shown that specific areas and peptidergic components of the social behavior network possess functional properties that evolve in parallel with divergence and convergence in sociality. Keywords sociality; aggression; sexual behavior; communication; vocalization; arginine vasopressin; arginine vasotocin; isotocin; mesotocin; oxytocin; fish; bird; bed nucleus of the stria terminalis; amygdala; lateral septum; anterior hypothalamus; ventromedial hypothalamus; preoptic area; periaqueductal gray; nucleus intercollicularis; c-fos; egr-1; ZenkThe research program described below is designed to address two major goals. The first of these goals is to elucidate evolutionary themes in the neuroendocrine, functional, and connectional organization of brain circuits that regulate social behavior. This will provide a phylogenetically broad framework for examining the neural and neuroendocrine mechanisms of behavior, and will allow detailed and meaningful comparisons to be made across the major vertebrate classes. Building upon this foundation, the second primary goal is to capitalize on the extraordinary behavioral diversity of birds and teleost (bony) fish to elucidate the ways that neural and neuroendocrine mechanisms are adjusted over evolutionary time to produce intraspecific and interspecific variation in behavior. If conducted within a well-characterized, comparative framework, these findings obtained in birds and fish should yield solid predictions for other vertebrates as well. Thus, our work addresses evolutionary themes, as described in the first section below, and variations on those themes, as...

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Section: The Social Behavior Network In a Vocalizing Fishsupporting

confidence: 64%

The vertebrate social behavior network: Evolutionary themes and variations

Goodson

2005

Hormones and Behavior

719

647

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“…The lateral septum [2,3], the preoptic area [2,8,7], the lateral amygdala [17] and the dorsal raphe nucleus [13] are involved in the inhibitory mechanisms for lordosis in male rodents, because destruction of these areas facilitates female sexual behavior. Especially, the septum and the dorsal raphe nucleus play an important role in producing the strong inhibition which makes a sex difference of sexual behavior regulating system [15].…”

Section: Discussionmentioning

confidence: 99%

“…Surgical removal of the inhibitions in both the sepnfrequency of female sexual behavioral patterns such as lordosis, ear-wiggling and hopping in I male rats is thought to be due to existence of strong inhibition in the central nervous systems [1]. The lateral septal nucleus is one of sources of the inhibition for lordosis behavior, because bilateral septal lesions enhance this behavior in estrogen-treated castrated male rats [2,3]. Since ventro-horizontal cut of the septum facilitates lordosis in males [4][5][6], the ventral efferents are important in sending the inhibition to the hypothalamus and/or the lower brainstem.…”

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confidence: 99%

Inhibitory Pathway for Female Sexual Behavior in Male Rat Brain: Effect of Medial Forebrain Bundle (MFB) Cuts.

Suzuki

Yamanouchi

1998

Journal of Reproduction and Development

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Abstract. In order to clarify the role of the medial forebrain bundle (MFB) in regulating female sexual behavior in male rats, lordosis and soliciting behavior were observed after transection of it. Male rats were castrated and received cutting of the bilateral MFB at the suprachiasmatic level or sham operation. As control groups, male and female rats were castrated without brain surgery. Behavioral test was carried out after implantation of Silastic tubes containing estradiol. As a result, all males with MFB cuts showed lordosis behavior. Lordosis quotient in this group was comparable to that of female control and was higher than those in the control male and sham male rats. Half male rats with MFB cuts but none of control and of sham males showed soliciting behavior. These results suggest that the MFB is an important inhibitory pathway for female sexual behavior in male rats.

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“…4 Despite the fact that the septum occupies strategic position in the limbic system, so far no specific have been attributed to it, except for its role in self stimulation, aggression and drinking behavior. 5 It is known that the lesions of the medial preoptic area (mPOA) inhibit the display of male sexual behavior [6][7][8][9][10] whereas electrical stimulation of mPOA facilitates it. 11,12 Swanson and Cown 13 have demonstrated that various parts of the septal nuclei project substantially to mPOA, laieral preoptic area and anterior hypothalamic area.…”

Section: Introductionmentioning

confidence: 99%

“…5,16 Conversely electrical stimulation of sexual area has been found to diminish lordotic activity in female hamsters. 17 Thus it is postulated that a lordosis inhibiting influence may exist in septal area.…”

Section: Introductionmentioning

confidence: 99%

The effect of septal lesion on sexual behavior, sperm count and testicular activity in Young male albino rats

2020

IJCAP

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The aim of this study was to assess the effect of septal lesion on sexual behavior, sperm count and testicular morphology in male albino rats. 24 adult sexually experienced male Haffkine albino rats, aged between 90-120 days and weighing between 200 -250 grams were selected for the study. They were divided into three groups Group I (n=8) as controls, Group II (n-8) were sham operated and Group III (n=8) were septal lesioned. The components of male sexual behavior are pursuit, mount, intromission and ejaculation. The latencies of different components of male sexual behavior were recorded by using separate stop watches for each of the parameters studied. Simultaneously frequencies of the different components of sexual behavior was also recorded in 10 minutes. The occurrence of each pursuit, mount, intromission and ejaculation was scored according to classical criteria. Testicular morphology and sperm count was estimated The results indicate that septal lesions are effective in suppressing the sexual behavior in rats as indicated by increase in pursuit, mount, intromission and ejaculation latencies (P<0.01) and shows significant decrease in intromission and ejaculation frequency (p<0.01) , decrease in sex drive (0.01) but no change in pursuit and mount frequency. There is statistically significant decrease in testicular weight in septally lesioned rats as compared to control and sham group. The sperm count is markedly reduced (p<0.01) in septally lesioned rat as compared to control and sham group. The present study shows that the bilateral lesion of the septal nuclei decreases the sexual behavior in male rats. The bilateral septal lesion also alters the testicular weight and morphology along with decrease in sperm count. This indicates that septal nuclei control the functions of reproductive organ in male rats. It would be worthwhile to estimate testosterone levels in male rats following septal lesions to elucidate the exact mechanism of action of septal lesion.

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Role of septum and preoptic area in regulating masculine and feminine sexual behavior in male rats

Cited by 122 publications

References 39 publications

The vertebrate social behavior network: Evolutionary themes and variations

The vertebrate social behavior network: Evolutionary themes and variations

Inhibitory Pathway for Female Sexual Behavior in Male Rat Brain: Effect of Medial Forebrain Bundle (MFB) Cuts.

The effect of septal lesion on sexual behavior, sperm count and testicular activity in Young male albino rats

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