Role of serial quantitative gallium-67 tumor uptake in assessing response rates for chemotherapy in lymphoma patients

Abstract

Quantitative GS is an effective tool in the detection of early response to chemotherapy. Quantitative response rates after the first cycle can more reliably identify patients who are most likely to be disease-free or relapse after first-line therapy or those that will show no response to therapy as compared with visual analysis alone.

Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease

“…While several of the radiometals such as 67 Cu − and 90 Y − are used in oncology as radiotherapeutics, the remainder of this discussion will focus on the incorporation of In, Cu, Ga, Y, and Zr radiometals into radiopharmaceuticals for the diagnostic imaging of cancer. Moreover, while numerous radiopharmaceuticals have been prepared to detect biomarkers such as the folate receptor, ,, the neurotensin receptor, , oxytocin receptor expressing tumors, apoptosis using annexin-5, − urokinase-type plasminogen activator receptor (uPAR), matrix metalloproteinases (MMPs), , Met-expression, antigens in head-and-neck cancer, ,− lymphoma, − non-Hodgkin’s lymphoma, and esophageal and pancreatic cancer, , the remainder of this discussion will be further confined to several biomarkers that have received the most attention and include the integrin α v β 3 , the somatostatin receptor, the gastrin-releasing peptide receptor, melanoma and melanocortin-1 receptor, HER-2/neu receptor, VEGF receptor, and EGF receptor.…”