Role of serum albumin as a carrier of 99mTc-complex to tumor tissue

Takeda, Atsüshi; Hibino, Tomoko; Hoshino, Akihiko; Okumura, Hayato; Okada, Shoji

doi:10.1016/0883-2897(91)90110-7

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…99m Tc‐homocysteine was reported to bind to HMA but not to HNA ( Takeda et al ., 1989 ). In addition, binding to and release from albumin and therefore the pharmacokinetics of thiol drugs are affected by the presence of other thiol compounds ( Takeda et al ., 1991 ; Raghunand et al ., 2006 ). Experiments in mice revealed that the tumour transport of 99m Tc‐homocysteine depended on its binding to albumin ( Takeda et al ., 1989 , 1990 , 1991 ) and in vitro albumin binding of the drug before its application may be of advantage.…”

Section: Binding Properties and Oxidation Of Albuminmentioning

confidence: 99%

Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties

Oettl¹,

Stauber²

2007

British J Pharmacology

316

266

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Binding and transport of a number of endogenous and exogenous compounds is an important function of the main plasma protein, albumin. In vivo and in vitro, albumin may be oxidatively modified in different ways with different agents at different sites. These modifications have various consequences on the physiological functions of albumin. Diabetes mellitus, liver diseases and nephropathy are just a few examples of disorders in which oxidative stress is involved and altered albumin functions have been described. This review is focussed on the consequences of oxidative modification on the binding properties of albumin. These range from no effect to decreased or increased binding affinities depending on the ligand under investigation and the type of modification. Indicators for modification include glycosylation, disulphide formation or the content of carbonyl groups. The redox state of albumin can affect the binding properties in several ways, including altered conformation and consequently altered affinities at binding sites and altered binding when the binding reaction itself is redox sensitive. The physiological or pathophysiological concentrations of different oxidatively modified albumin molecules vary over a wide range and are crucial in assessing the clinical relevance of altered ligand binding properties of a particularly modified albumin species in various disease conditions.

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Section: Binding Properties and Oxidation Of Albuminmentioning

confidence: 99%

Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties

Oettl¹,

Stauber²

2007

British J Pharmacology

316

266

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“…The decrease in concentration ratios observed with both " m Tc-Cys and " m Tc-G might be attributed to their smaller size compared to " m Tc-HIG. However, Takeda et al (21)(22)(23)(24)26) who demonstrated the accumulation of W m Tc-Cys and " m Tc-homocysteine in experimental tumors attributed this to the formation of polymeric species and to their transport by carrier serum proteins to the lesion site. Formation of polymeric species was also reported for " m T c (V)-DMSA and 6 7 Ga-citrate (21).…”

Section: Discussionmentioning

confidence: 99%

Accumulation of 99mTc-Cysteine in Experimental Inflammatory Lesions in Comparison to 99mTc-Glutamine and 99mTc-HIG

Ercan¹,

Gülaldı²,

U³

et al. 1997

Nuklearmedizin

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Summary Aim: The aim of this experimental work was to investigate the efficacy of 99mTc-L-Cysteine (Cys) in scintigraphic visualization of inflammatory lesions in comparison to 99mTc-L-glutamine (G), and 99mTc-HIG. Methods: In mice abscesses were induced by intramuscular injection of turpentine. Six days later mice were injected with 3.7 MBq of each agent and sacrificed in groups of three at 1, 3, 6 and 24 h. Scintigrams were obtained with a gamma camera. The organs, some blood, abscesses, some muscle and urine were removed, weighed and counted in a gamma counter. Percentage of uptake by organs and per gram tissues and abscess/normal tissue concentration ratios were calculated. Experimental arthritis was produced in 6 New Zealand rabbits by intraarticular injection of ovalbumin. Four days later 37 MBq of 99mTc-Cys and 99mTc-HIG were each i.v. administered to 3 rabbits. Scintigrams obtained at 1, 3, 6, and 24 h demonstrated the arthritic joints very well. ROI’s over arthritic joints were compared to contralateral normal joints (A/C). Results: In mice the abscesses were well visualized on all scintigrams. The maximum abscess/muscle ratios were 5.21 ±1.09 (6 h), 3.73 ± 0.81 (3 h) and 5.98 ± 1.17 (24 h) and the maximum abscess/blood ratios were 3.46 ± 1.33 (24 h), 1.81 ± 0.10 (6 h) and 0.914 ± 0.351 (24 h) for 99mTc-Cys, 99mTc-G, and 99mTc-HIG, respectively. In rabbits the maximum A/C ratios were 2.61 ± 0.53 (3 h) and 2.92 ± 0.99 (24 h) for 99mTc-Cys and 99mTc-HIG, respectively. Conclusion: our results indicate that 99mTc-Cys is a promising agent for imaging inflammatory lesions. It is preferred to 99mTc-HIG, because of higher concentration ratios attained earlier, lower blood background, lower cost and a simpler in-house preparation method.

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“…GSH is a cysteine carrier in blood and it plays a significant role in detoxification reactions by reducing H 2 O 2 formed as a by-product of oxygen-requiring metabolism. These considerations led to the development of 99m Tc-GSH and its evaluation in inflammatory and malignant lesions [21,[192][193][194][195]. These considerations led to the development of 99m Tc-GSH and its evaluation in inflammatory and malignant lesions [21,[192][193][194][195].…”

Section: Nonspecific Amino Acids and Peptidesmentioning

confidence: 99%

Radiopharmaceuticals for the Visualization of Infectious and Inflammatory Lesions

Ercan¹,

Kostakoğlu²

2000

CPD

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Many radiopharmaceuticals have been introduced for the scintigraphic demonstration of infectious and inflammatory lesions and some of them are currently in clinical use. They can be classified into two major categories according to their specificity. Specific radiopharmaceuticals include in vitro labeled leukocytes, radio-labelled monoclonal antibodies, and receptor specific small proteins and peptides. Nonspecific radiopharmaceuticals include radiolabelled nanocolloids, liposomes, macromolecules such as human immunoglobulin, dextran and human serum albumin, various small molecules and ions. In this review article radiopharmaceuticals in their respective groups are discussed as to the efficacy, and other parameters such as the physical characteristics of the radionuclides used, radiochemistry involved, availability, cost and biodistribution, emphasizing recent developments.

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Role of serum albumin as a carrier of 99mTc-complex to tumor tissue

Cited by 7 publications

References 6 publications

Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties

Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties

Accumulation of 99mTc-Cysteine in Experimental Inflammatory Lesions in Comparison to 99mTc-Glutamine and 99mTc-HIG

Radiopharmaceuticals for the Visualization of Infectious and Inflammatory Lesions

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