2024
DOI: 10.1038/s41598-024-65857-w
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Role of serum complement C3 and C4 on kidney outcomes in IgA nephropathy

Edoardo Tringali,
Daniele Vetrano,
Francesco Tondolo
et al.

Abstract: IgA Nephropathy (IgAN) is the most prevalent glomerular disease worldwide. Complement system activation is crucial in its pathogenesis. Few studies correlated serum C3 and C4 with disease activity and prognosis. This retrospective study investigated the prognostic value of serum complement at the time of diagnosis in patients with IgAN. Specifically we evaluated whether adding serum C3 and C4 levels to established predictive models-one based on variables related to chronic kidney disease (CKD) progression and … Show more

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