Role of Serum Homocysteine and Outcome in Patients With Traumatic Brain Injury

Amini, Humayoun; Hewadmal, Hewad; Rasuli, Sayed Farhad; Shahriar, Chowdhury S; Fattah, Abdul; Sridhar, Hariharan Kavanoor; Khan, Marjan; Bhat, Sadaf; Talpur, Abdul Subhan

doi:10.7759/cureus.28968

Cited by 1 publication

(1 citation statement)

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“…Elevated Hcy levels, through their role in the catabolism of choline and folate, are crucial for maintaining methionine activity and protein synthesis. These elevated levels contribute to the production of reactive oxygen species, resulting in cellular damage through mechanisms such as lipid peroxidation [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinemia in a Patient With Subdural Hematoma and Subarachnoid Hemorrhage Secondary to a Traumatic Brain Injury

Elias,

Mohib,

Saleem

et al. 2024

Cureus

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Traumatic brain injury (TBI) is a significant global health issue, contributing substantially to mortality and disability. Serum biomarkers, such as homocysteine (Hcy), play a critical role in the prognosis of brain injuries, with hyperhomocysteinemia (HHcy) potentially leading to neurological disorders. We present the case of a 64-year-old patient admitted to the emergency department following a road traffic accident (RTA). Magnetic resonance imaging (MRI) revealed parietal subdural hematoma (SDH), right frontal contusion, and left subarachnoid hemorrhage (SAH). The patient underwent a craniotomy to address SAH and SDH. Initial Hcy levels were markedly elevated compared to post-operative levels. Hcy represents a rapid, non-invasive, and cost-effective diagnostic tool for assessing brain injury severity and guiding medical intervention. Early detection of HHcy could potentially mitigate vascular and neurological complications, thereby improving patient outcomes.

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Section: Introductionmentioning

confidence: 99%