Role of serum leptin levels and leptin receptor gene polymorphisms in systemic lupus erythematosus

Afifi, Abd El-Moaty Ali; Shaat, Reham M.; Gharbia, Ola Mohamed; Elhanafy, M; Hasan, Al Shimaa Goda

doi:10.1007/s10067-020-05120-5

Cited by 9 publications

(4 citation statements)

References 32 publications

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“…In accord with these findings, several recent studies have found significantly greater serum leptin concentrations in SLE patients compared to matched healthy controls in diverse populations from the Middle East and South America. 13 , 17 , 18 Further, a meta-analysis of 18 studies comprising 1333 patients and 1048 controls found leptin elevation among SLE patients irrespective of ethnicity. 17 However, an earlier study from Poland found no such difference.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous cytokines, including interleukin (IL)-2, IL-4, IL-6, interferon gamma, and tumor necrosis factor (TNF)-alpha, and adipokines such as leptin, adiponectin, resistin, and visfatin are elevated in SLE. 13 Historically, adipose tissue has been considered largely inert physiologically and pathologically but is now known to participate in immunity and inflammation through section of adipokines, cytokines, and chemokines that act both locally and systemically. 11 For instance, adipocyte-derived immunomodulators (adipokines) have been implicated in the regulation of insulin sensitivity, appetite, and satiety, in bone metabolism and reproductive function, and in atherosclerosis as well as immunity and inflammation.…”

Section: Discussionmentioning

confidence: 99%

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High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus

Kamel

Elazeem

Mohamed

et al. 2023

Int J Immunopathol Pharmacol

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Objectives: Leptin and adiponectin are adipose-derived immune modulators (adipokines) that may contribute to SLE pathology and symptoms. This study aimed to evaluate the associations of serum adiponectin and leptin with clinical manifestations and disease activity in SLE patients. Methods: This is a case control study, where 70 SLE patients and 50 age- and sex-matched healthy controls were enrolled from the Rheumatology and Rehabilitation Department of Beni-Suef University Hospital from June 2020 till April 2022. The SLE disease activity index (SLEDAI) and Systemic Lupus International Collaborative clinics/America Collage of Rheumatology damage index were used to assess disease severity. Laboratory parameters including erythrocyte sedimentation rate (ESR) and serum concentrations of antinuclear antibody (ANA), anti-double stranded DNA, complement 3 and 4, lipids, and C-reactive protein (CRP) were measured and compared between SLE and control groups. Serum adiponectin and leptin were also measured by enzyme-linked immunosorbent assays (ELISA). Results: Compared to healthy controls, SLE patients exhibited significantly greater serum leptin (21.1 vs 3.9 ng/mL, p < 0.001) and adiponectin (18.1 vs 4.8 ng/mL, p < 0.001), and both values were positively correlated with SLEDAI scores ( p = 0.048 and 0.042). Higher serum leptin was significantly associated with lupus nephritis (LN) ( p = 0.048) as well as greater body mass index ( p = 0.010), ESR ( p = 0.002), serum CRP ( p = 0.003), total cholesterol ( p = 0.013), and uric acid ( p = 0.002), while higher adiponectin was significantly associated with LN ( p = 0.046). Conclusion: Serum leptin and adiponectin levels are associated with the clinical and pathological manifestations of SLE, suggesting direct involvement in disease progression and utility as diagnostic biomarkers and therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus

Kamel

Elazeem

Mohamed

et al. 2023

Int J Immunopathol Pharmacol

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“…Leptin is the expression product of obesity genes [ 61 ]. It is widely involved in the regulation of various physiological activities of the human body, such as food intake, energy consumption and metabolism, hormone regulation, immunity, and vascular proliferation [ 62 ]. The levels of leptin, as a negative feedback signal of central fat deposition in the brain, increase with increasing fat deposition [ 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Abnormal Phenylalanine Metabolism of Procapra przewalskii in Chronic Selenosis in Selenium-Enriched Habitats

Ren,

Zhou,

Shen

2023

Metabolites

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Selenium (Se)-enriched habitats have led to chronic selenosis, seriously affecting the health and survival of Procapra przewalskii (P. przewalskii). Our targets were to explore the molecular mechanisms of chronic selenosis and to look for a new way to protect endangered species. The mineral contents of soils, grass, blood, and muscle were analyzed. The biochemical indices, antioxidant capability, and immune function were also investigated. The analyses of proteomics and metabolomics were also carried out. The results showed that the Se contents in the muscle and blood of P. przewalskii, and the soil and grass in the Se-enriched habitats were significantly higher than those in healthy pastures. The P. przewalskii in the Se-enriched habitats showed symptoms of anemia, decreased antioxidant capability, and low immune function. A total of 44 differential proteins and 36 differential metabolites were screened by analyzing their proteomics and metabolomics. These differential proteins and metabolites were involved in glycolysis pathway, amino acid biosynthesis, carbon metabolism, phenylalanine metabolism, and energy metabolism. In particular, phenylalanine metabolism was the common pathway of proteomics and metabolomics, which was an important finding in studying the mechanism of chronic selenosis in animals. This study will help us to further understand the mechanism of chronic selenosis in P. przewalskii, and it provides a scientific basis for the protection of endangered species in Se-enriched habitats.

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“…[18], наоборот, выявили более низкий уровень лептина при поражении суставов и центральной нервной системы. Отсутствие связи между концентрацией лептина и активностью СКВ продемонстрировано в нескольких исследовани-ях [5,15,[19][20][21], наряду с этим М. Vadacca и соавт. [22] сообщили о прямой, а D. Chougule и соавт.…”

Section: Introductionunclassified

Clinical significance of leptin in systemic lupus erythematosus

Kondratyeva¹,

Panafidina²,

Попкова³

et al. 2021

Sovremennaâ revmatologiâ

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Objective: to study the frequency of hyperleptinemia in patients with systemic lupus erythematosus (SLE), its relationship with clinical and laboratory manifestations of the disease, drug therapy, and other metabolic disorders.Patients and methods. The cross-sectional study included 46 women with a definite diagnosis of SLE (median age 40 [31; 48] years) and disease duration 3.0 [0.9; 9.0] years. Glucocorticoids (GC) were received by 38 (83%) patients, hydroxychloroquine – by 35 (76%), immunosuppressants – by 10 (22%), biologic disease-modifying antirheumatic drugs – by 5 (11%). In all patients, fasting levels of glucose, leptin, apoliproprotein B (ApoB) and immunoreactive insulin were determined, and homeostatic model assessment for insulin resistance (HOMA-IR) was calculated. Concentration of leptin ≥11.1 ng/ml, ApoB – >1.6 mg/ml were considered an elevated level. HOMA-IR index ≥2.77 corresponded to the presence of insulin resistance (IR).Results and discussion. Hyperleptinemia was found in 34 (74%) patients with SLE, an increased level of ApoB – in 19 (41%), IR – in 10 (22%). In patients with hyperleptinemia, serositis, positivity for anti-double-stranded DNA (aDNA) and hypocomplementemia were less common, overweight and obesity were more frequent, the SLEDAI-2K index was lower, the aDNA level was lower, and the concentration of the C3 component of complement, insulin, HOMA-IR index, body mass index (BMI) and disease duration were higher (p<0.05 for all cases). BMI <25 kg / m2 had 26 (57%) women, 14 (54%) of whom had hyperleptinemia. In patients with BMI <25 kg / m2, we found a relationship between leptin concentration and disease duration (r=0.4, p=0.04), SLE activity according to SLEDAI-2K (r=-0.6, p=0.003), levels of aDNA (r=-0.6, p<0.001), C3 component of complement (r=0.5, p=0.01), maximum (r=0.7, p<0.001) and supporting (r=0,5, p=0.023) GC doses.In patients with BMI ≥25 kg/m2 (n=20), no such relationship was observed.Conclusion. Hyperleptinemia was found in the majority of women with SLE; elevated levels of ApoB and IR were much less common. Patients with hyperleptinemia are characterized by a longer duration and less activity of the disease, as well as the presence of overweight and obesity and an increase in the HOMA-IR index. In SLE patients with normal body weight, the concentration of leptin increased along with GC dose elevation.

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Role of serum leptin levels and leptin receptor gene polymorphisms in systemic lupus erythematosus

Cited by 9 publications

References 32 publications

High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus

High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus

Abnormal Phenylalanine Metabolism of Procapra przewalskii in Chronic Selenosis in Selenium-Enriched Habitats

Clinical significance of leptin in systemic lupus erythematosus

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