Role of Serum Markers for Liver Function and Liver Regeneration in the Management of Chloroform Poisoning

Rao, Kalipatnapu N.; Virji, Mohamed A.; Moraca, Michael; Diven, Warren F.; Martin, Thomas G.; Schneider, Sandra

doi:10.1093/jat/17.2.99

Cited by 30 publications

(16 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][4][5] Some viable liver tissue must remain to provide a mitotic nidus that will enable regeneration of lost portions and will also produce the measurable serum biomarkers that indicate such growth. Thus these results support our contention from a previous study 9 that sequential analysis of serum biomarkers for liver necrosis and regeneration, and a consistent significant decline in normalized mean values of necrosis and an increase in normalized mean values of regeneration can provide an early means of predicting outcome in patients with acute hepatic necrosis.…”

Section: Hours After Admissionsupporting

confidence: 90%

“…We previously reported a case of chloroform poisoning in which sequential analysis of serum samples suggested that a decrease in markers for liver necrosis (ie, LDH, ALT, AST, ALP) and an increase in markers indicating hepatocytic regeneration (ie, GGT, RBP, DCP, AFP) could be used to predict outcome in these patients. 9 We now present 8 cases of acute toxic liver injury in which serial assay of these markers was retrospectively suggestive of outcome following acute hepatic necrosis.…”

Section: Acute Toxic Hepatic Necrosis Is Common and May Be Fatal Prementioning

confidence: 99%

See 1 more Smart Citation

Biomarkers of Liver Regeneration Allow Early Prediction of Hepatic Recovery After Acute Necrosis

et al. 1999

View full text Add to dashboard Cite

Section: Hours After Admissionsupporting

confidence: 90%

Section: Acute Toxic Hepatic Necrosis Is Common and May Be Fatal Prementioning

confidence: 99%

Biomarkers of Liver Regeneration Allow Early Prediction of Hepatic Recovery After Acute Necrosis

et al. 1999

View full text Add to dashboard Cite

“…13 A number of studies have demonstrated that patients who exhibit timely stimulation of the timely compensatory liver regeneration following APAP overdose have a good prognosis. 8,9,30 Such timely regeneration has been linked to survival following exposure to hepatotoxic drugs and chemicals such as APAP, CCl 4 , and chloroform. 10,12,14,30 Here, we also demonstrate the importance of spontaneous regeneration in survival following APAP-induced ALF and identify the role of Wnt/␤-catenin signaling in this process as well.…”

Section: Discussionmentioning

confidence: 99%

“…8,9,30 Such timely regeneration has been linked to survival following exposure to hepatotoxic drugs and chemicals such as APAP, CCl 4 , and chloroform. 10,12,14,30 Here, we also demonstrate the importance of spontaneous regeneration in survival following APAP-induced ALF and identify the role of Wnt/␤-catenin signaling in this process as well. 15 Our observations indicate that ␤-catenin activation is an early event and is vital for regeneration after APAPinduced ALF.…”

Section: Discussionmentioning

confidence: 99%

Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury

Apte

Singh

Zeng

et al. 2009

The American Journal of Pathology

150

137

View full text Add to dashboard Cite

Acute liver failure (ALF) remains a disease with poor patient outcome. Improved prognosis is associated with spontaneous liver regeneration, which supports the relevance of exploring 'regenerative' therapies. Therefore, the role of the Wnt/␤-catenin pathway in liver regeneration following ALF was investigated. ALF was induced in mice by acetaminophen overdose, which is also a leading cause of liver failure in patients. ␤-catenin distribution was also studied in liver sections from acetaminophen-induced ALF patients. A nonlethal dose of acetaminophen, which induces liver regeneration, led to stabilization and activation of ␤-catenin for 1 to 12 hours. These data were also verified by increased expression of the ␤-catenin surrogate target glutamine synthetase. ␤-Catenin activation occurred secondary to the inactivation of glycogen synthase kinase-3␤ and an increase in levels of casein kinase 2␣, and led to increased cyclin-D1, another known ␤-catenin target. These observations were next substantiated in ␤-catenin conditional-null mice (␤-catenin-null), which show dampened regeneration after acetaminophen injury following induction of CYP2e1/1a2 expression. In light of decreased acetaminophen injury in ␤-catenin-null mice despite CYP induction, equitoxic studies in control mice were performed. Significant differences in regeneration persisted following comparable injury in ␤-catenin-null and control animals. Retrospective analysis of liver samples from acetaminophen-overdose patients demonstrated a positive correlation between nuclear ␤-catenin, proliferation, and spontaneous liver regeneration. Thus, our studies demonstrate early activation of ␤-catenin signaling during acetaminophen-induced injury, which contributes to hepatic regeneration.

show abstract

“…Si l'hépatotoxicité et la néphrotoxicité de ces produits lors d'intoxications aiguës et subaiguës sont bien connues (LAVIGNE et MARCHAND, 1974 ;CONDIE et ai, 1983 ;RAO et al, 1993), leurs effets à long terme et à faible dose restent le sujet d'un vaste débat (BULL er ai, 1990 ;NEAL, 1990). Certains trihalométhanes (THM), tels que le bromodichloromethane et le bromoforme, se sont avérés cancérogènes chez l'animal (THEiss étal., 1977 ;BULL, 1985 ;DUNNICK et al, 1987).…”

Section: Haemodialysis Processunclassified

Évaluation du risque toxique lié à la prévalence de trihalométhanes dans l'eau utilisée pour la dialyse

Ambroise¹,

Blech²,

Majo³

et al. 2005

rseau

View full text Add to dashboard Cite

L'hémodialyse est une thérapeutique réservée aux sujets insuffisants rénaux en attente d'une greffe. Elle permet de recueillir dans un soluté aqueux les déchets que l'organisme ne peut plus évacuer par voie rénale. L'eau nécessaire à la préparation de ce dialysat représente un volume de 90 à 200 litres par séance et par sujet. Elle est obtenue en faisant subir à l'eau du réseau de distribution un traitement complémentaire. Celui-ci comporte en milieu spécialisé une chloration, un adoucissement par résines cationiques, une filtration sur colonne de charbon actif en grains et une osmose inverse.Les trihalométhanes sont probablement les sous-produits de chloration les plus répandus dans les eaux distribuées. Certains parmi eux sont cancérigènes chez l'animal et mutagènes in vitro. Chez l'homme, leurs effets à faibles doses et à long terme restent discutés. Compte tenu des importants volumes d'eau nécessaires à la pratique de l'hémodialyse, il nous a paru intéressant d'observer l'efflcacité du circuit de pré-traitement sur ces composés et d'évaluer les doses auxquelles sont exposés les patients qui bénéficient de cette thérapeutique.Des prélèvements ont été réalisés aux différentes étapes du pré-traitement, de façon hebdomadaire dans deux installations identiques, à la recherche de trihalométhanes. Ils permettent de constater que du chloroforme à une concentration moyenne de 10,5 llgA est encore présent en bout de chaîne. En tenant compte des volumes d'eau utilisés pour chaque séance, ceci signifie que les patients dialysés sont exposés, selon leur âge, à des doses pouvant atteindre jusqu'à dix fois la valeur préconisée dans l'eau potable par l'OMS. La moitié de ce chloroforme est susceptible de passer dans la circulation sanguine et d'exercer un effet toxique. Cette situation peut être corrigée par le choix d'une ressource en eau à charge organique faible, par un renouvellement fréquent du charbon actif et par l'utilisation de membranes en polyamides dans les modules d'osmose inverse. Ces résultats doivent amener à une réflexion plus générale sur la présenoe de sous-produits de la chloration et de micropolluants dans l'eau utilisée en dialyse. Ils doivent également inciter les cliniciens à rechercher, chez les dialysés les plus exposés, d'éventuels effets délétères liés à ces produits.Hemodialysis is an indispensable therapy for patients with chronic renal failure. Two or three times a week and over several years, their blood is dialyzed in an artificial kidney against a dialysis fluid called dialysate.Each time, 90 to 200 liters of this fluid will flow through the apparatus. Before being mixed with the dialysis concentrate, the water will be treated in order to eliminate harmful substances such as aluminum or endotoxins.Trihalomethanes (THM) are probably the most widespread chlorination byproducts of tap water. Most of them are known as carcinogens for animals and mutagens in vitro. Although their hepatotoxicity and nephrotoxicity are obvious after acute intoxication, their effects at low doses on human health have...

show abstract

Role of Serum Markers for Liver Function and Liver Regeneration in the Management of Chloroform Poisoning

Cited by 30 publications

References 21 publications

Biomarkers of Liver Regeneration Allow Early Prediction of Hepatic Recovery After Acute Necrosis

Biomarkers of Liver Regeneration Allow Early Prediction of Hepatic Recovery After Acute Necrosis

Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury

Évaluation du risque toxique lié à la prévalence de trihalométhanes dans l'eau utilisée pour la dialyse

Contact Info

Product

Resources

About