Role of serum Metadherin mRNA expression in the diagnosis and prediction of survival in patients with colorectal cancer

Ghafar, Muhammad Tarek Abdel; Gharib, Fatma; Abd‐Elsalam, Sherief; Elkhouly, Reham Abdelkader; Elshora, Ahmed; Shalaby, Khaled Hamed; El-Guindy, Dina M.; Elrashidy, Mohamed; Soliman, Nema A.; Abu-Elenin, Mira M.; Allam, Abdallah El Sayed

doi:10.1007/s11033-020-05334-5

Cited by 49 publications

(34 citation statements)

References 37 publications

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“…Besides, ERO1L significantly increased the Wnt/catenin pathway activity through regulating the downstream genes of Wnt/catenin including MYC, CD44, RUNX2, and SNAI1. [ 42 ] Previous studies have suggested that the serum metadherin mRNA and serum HtrA2 mRNA could be served as potential diagnosis biomarkers for colorectal cancer [ 43 ] and breast cancer, [ 44 ] respectively.…”

Section: Discussionmentioning

confidence: 99%

A panel of 8 miRNAs as a novel diagnostic biomarker in pancreatic cancer

2020

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Pancreatic cancer (PC) is one of the major causes of cancer mortality in developed countries. Therefore, there is an urgent need to derive biomarkers for early diagnosis of PC patients at high risk. This study was designed to identify a panel of miRNAs that might serve as biomarkers for the early diagnosis of PC. The data containing both PC and control samples were extracted from the Gene Expression Omnibus (GEO) database. EdgeR was applied to identify the differentially expressed miRNAs and genes between PC patients and healthy controls. Then a miRNA-mRNA network was constructed based on the differentially expressed miRNAs and genes. The miRNAs-based biomarker for PC was finally constructed by random forest. Finally, AUC was used to evaluate the performance of miRNAs to classify PC and control samples. A total of 33 differentially expressed miRNAs, 753 differentially expressed genes, and 8 miRNAs (hsa-mir-139, hsa-mir-31, hsa-mir-196b, hsa-mir-221, hsa-mir-203b, hsa-mir-215, hsa-mir-144, and hsa-mir-4433b) that play important roles in PC were identified. The target genes of these miRNAs were found to be mainly enriched in negative regulation of acute inflammatory response cell-substrate responses, and o-glycan processing pathways. The constructed biomarkers based on these 8 miRNAs could distinguish samples coming from PC and healthy controls. We identified a panel of eight-miRNAs that would serve as early diagnostic biomarkers for PC patients.

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Section: Discussionmentioning

confidence: 99%

A panel of 8 miRNAs as a novel diagnostic biomarker in pancreatic cancer

2020

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“…[ 5 ] Therefore, it is important to identify effective markers that could help in survival prognosis and could also be served as therapeutic targets. The recent advances [ 6 – 8 ] in prognostic markers provided important evidence of clinical use of those indicators. For patients with colorectal cancer (CRC), Metadherin mRNA expression is a useful non-invasive biomarker.…”

Section: Introductionmentioning

confidence: 99%

“…For patients with colorectal cancer (CRC), Metadherin mRNA expression is a useful non-invasive biomarker. [ 6 ] Metadherin mRNA expression is effective for screening and early diagnosis of CRC; and is correlated to advanced tumor stage and a poor prognosis. [ 6 ] Circulating high-temperature-required protein A2 (HtrA2) mRNA expression was reported as a significant diagnostic marker for breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…[ 6 ] Metadherin mRNA expression is effective for screening and early diagnosis of CRC; and is correlated to advanced tumor stage and a poor prognosis. [ 6 ] Circulating high-temperature-required protein A2 (HtrA2) mRNA expression was reported as a significant diagnostic marker for breast cancer. [ 7 ] Decreased serum HtrA2 expression was associated with poor histological grade and advanced TNM stages in breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of tumor-associated macrophages in patients with nasopharyngeal carcinoma

Chen¹

2020

Medicine

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Background: To explore the prognostic value of diverse subsets of tumor-associated macrophages (TAMs) in prognosis in patients with nasopharyngeal carcinoma (NPC) using meta-analysis. Methods: Relevant studies were searched in the database of PubMed, Web of Science, Embase, Cochrane Library, Scopus, China National Knowledge Infrastructure (CNKI), and Wanfang till November 2019. The relationship between TAMs and survival outcomes was estimated by pooling hazard ratios (HRs) and 95% confidence intervals (CIs); and the correlation of TAMs and clinicopathological factors was evaluated by using odds ratios (ORs) and 95%CIs. Results: Six studies with 1549 patients were included in this meta-analysis. The high expression of CD68+ TAMs was associated with favorable disease-free survival (DFS) (HR = 0.66, 95%CI = 0.50–0.88, P = .005), whereas the density of M2-like TAMs (CD163+, CD68+CCL18+, and CD206+) was correlated to poor overall survival (OS) (HR = 1.77, 95%CI = 1.22–2.56, P = .003) and DFS (HR = 1.96, 95%CI = 1.00–3.85, P = .050) in patients with NPC. Conclusions: CD68+ TAM density is associated with superior DFS, while CD163+ M2-like TAMs predicted poor prognosis in patients with NPC.

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“…Most cancer types have some classic but limited biomarkers which cannot always meet clinical requirements. Therefore, increasing studies are focusing on finding new and effective tumor gene markers in various cancer types [ 1 – 3 ]. However, to meet more complex and more personalized clinical needs, tumor-related genes still need further and deeper exploitation.…”

Section: Introductionmentioning

confidence: 99%

Expression profile of SYNE3 and bioinformatic analysis of its prognostic value and functions in tumors

et al. 2020

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Background Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an essential component of the linker of the cytoskeleton and nucleoskeleton (LINC) complex, namely nesprin-3. In a tumor, invasiveness and metastasis rely on the integrity of the LINC complex, while the role of SYNE3/nesprin-3 in cancer is rarely studied. Methods Here, we explored the expression pattern, prognostic value, and related mechanisms of SYNE3 through both experimental and bioinformatic methods. We first detected SYNE3 in BALB/c mice, normal human tissues, and the paired tumor tissues, then used bioinformatics databases to verify our results. We further analyzed the prognostic value of SYNE3. Next, we predicted miRNA targeting SYNE3 and built a competing endogenous RNA (ceRNA) network and a transcriptional network by analyzing data from the cancer genome atlas (TCGA) database. Interacting genes of SYNE3 were predicted, and we further performed GO and KEGG enrichment analysis on these genes. Besides, the relationship between SYNE3 and immune infiltration was also investigated. Results SYNE3 exhibited various expressions in different tissues, mainly located on nuclear and in cytoplasm sometimes. SYNE3 expression level had prognostic value in tumors, possibly by stabilizing nucleus, promoting tumor cells apoptosis, and altering tumor microenvironment. Additionally, we constructed a RP11-2B6.2-miR-149-5p-/RP11-67L2.2-miR-330-3p-SYNE3 ceRNA network and a SATB1-miR-149-5p-SYNE3 transcriptional network in lung adenocarcinoma to support the tumor-suppressing role of SYNE3. Conclusions Our study explored novel anti-tumor functions and mechanisms of SYNE3, which might be useful for future cancer therapy.

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Role of serum Metadherin mRNA expression in the diagnosis and prediction of survival in patients with colorectal cancer

Cited by 49 publications

References 37 publications

A panel of 8 miRNAs as a novel diagnostic biomarker in pancreatic cancer

A panel of 8 miRNAs as a novel diagnostic biomarker in pancreatic cancer

Prognostic significance of tumor-associated macrophages in patients with nasopharyngeal carcinoma

Expression profile of SYNE3 and bioinformatic analysis of its prognostic value and functions in tumors

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