Role of SET oncoprotein in hepatocellular carcinoma: An immunohistochemical study

Gadallah, Marwa; Asaad, Nancy Youssef; Shabaan, Mohammed; Elkholy, Shimaa Saad; Samara, Manar Yousef; Taie, Doha Maher

doi:10.1080/15321819.2022.2034646

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Moreover, SET expression in tumor tissues was identified as an independent prognostic factor for overall survival of HCC patients. These findings suggest that SET may serve as a prognostic indicator and potential therapeutic target in HCC patients ( Gadallah et al., 2022 ).…”

Section: Dysfunction Of Set In Disease Contextsmentioning

confidence: 95%

The next decade of SET: from an oncoprotein to beyond

Yao,

Zhang,

Wang

2023

Journal of Molecular Cell Biology

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This year marks the fourth decade of research into the protein SET, which was discovered in 1992. SET was initially identified as an oncoprotein, but later, it was shown to be a multifaceted protein involved in regulating numerous biological processes under both physiological and pathophysiological conditions. SET dysfunction is closely associated with diseases, such as cancer and Alzheimer's disease. With the increasing understanding of how SET works and how it is regulated in cells, targeting aberrant SET has emerged as a potential strategy for disease intervention. In this review, we present a comprehensive overview of the advancements in SET studies, encompassing its biological functions, regulatory networks, clinical implications, and pharmacological inhibitors. Furthermore, we provide insights into the future prospects of SET research, with a particular emphasis on its promising potential in the realm of immune modulation.

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Section: Dysfunction Of Set In Disease Contextsmentioning

confidence: 95%

The next decade of SET: from an oncoprotein to beyond

Yao,

Zhang,

Wang

2023

Journal of Molecular Cell Biology

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Metabolomic profiling and cytotoxic potential of three endophytic fungi of the genera Aspergillus, Penicillium and Fusarium isolated from Nigella sativa seeds assisted with docking studies

Shady

Zhang

Sobhy

et al. 2022

Natural Product Research

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The main aim of our study is to investigate the anticancer potential of our cultivated entophytic fungal strains from Nigella sativa seeds. The strains were identified by sequencing of the partial 18S rRNA gene and the internal transcribed spacer (ITS) region as Aspergillus sp. (SA4), Penicillium sp. (SA5), and Fusarium sp. (SA6). We carried out metabolic profiling for three fungal strains to investigate their metabolites diversity.Profiling of the different extracts revealed their richness in diverse metabolites and consequently fourteen compounds (1-14) were annotated. In addition, the obtained extracts were examined against three cell lines HepG2, MCF-7 and Caco-2 showed activity with IC50 values in the range of 1.95-39.7 μg/mL. Finally, molecular docking study was performed showing questinol as the lowest glide binding score value (-5.925 kcal/mol) among all identified compounds. Our results showed Nigella sativa-associated endophytes as a promising source for further studies to look for anticancer secondary metabolites.

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The Prognostic Impact of SIRT1, STAT3, and YAP1 in Colorectal Carcinoma

Elkholy,

Abdelbary,

Elazab

et al. 2024

Applied Immunohistochemistry &Amp; Molecular Morphology

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Colorectal cancer (CRC) is the most common gastrointestinal malignancy with a complicated behavior including relapse, metastasis, and development of resistance to chemotherapeutic drugs. Silent information regulator 2 homologue 1 (SIRT1), signal transducer and activator of transcription 3 (STAT3), and yes-associated protein (YAP) are cancer-related genes that have unclarified actions and even controversial roles in many human cancers including CRC. The current study aimed to evaluate the prognostic roles of SIRT1, STAT3, and YAP in CRC. Hundred and 13 CRC archival blocks were processed by TMA technique and immunostained with SIRT1, STAT3, and YAP antibodies. SIRT1, STAT3, and YAP are expressed in both tumor and stromal cells. SIRT1 expression in both the epithelial and stromal compartments was associated with favorable prognostic parameters, including longer overall and recurrence-free survival. In contrast, the epithelial and stromal expression of both STAT3 and YAP1 was associated with poor prognostic parameters, including short overall and recurrence-free survival. STAT3 and YAP epithelial expression showed a positive correlation with one another, but a negative correlation with epithelial SIRT1. While SIRT1 stromal expression was inversely correlated with stromal YAP expression, STAT3 and YAP concurrent stromal expression demonstrated a positive correlation with one another. There is crosstalk between CRC tumor and stromal cells by the coparallel expression of molecules such as SIRT1, STAT3, and YAP. There is a synergism between the STAT3 and YAP pathways in CRC at the level of the tumor and stroma. The tumor microenvironment of CRC could modulate tumor behavior by expressing markers suppressing invasion, such as SIRT1 or enhancing invasion, such as STAT3 and YAP.

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Role of SET oncoprotein in hepatocellular carcinoma: An immunohistochemical study

Cited by 3 publications

References 35 publications

The next decade of SET: from an oncoprotein to beyond

The next decade of SET: from an oncoprotein to beyond

Metabolomic profiling and cytotoxic potential of three endophytic fungi of the genera Aspergillus, Penicillium and Fusarium isolated from Nigella sativa seeds assisted with docking studies

The Prognostic Impact of SIRT1, STAT3, and YAP1 in Colorectal Carcinoma

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