Role of sex steroids and their receptors in human preterm infants: Impacts on future treatment strategies for cerebral development

Hübner, Stephanie; Reich, Bettina; Heckmann, Matthias

doi:10.1016/j.bcp.2015.08.093

Cited by 20 publications

(15 citation statements)

References 94 publications

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“…Despite the progress of neonatal medicine improving their survival rate, the incidence of premature babies has increased in most of the countries ( 2 – 4 ). Prematurity is linked to subcortical white and gray matter lesions and to impaired structural connectivity ( 5 , 6 ), leading to lifelong neurodevelopmental disturbances ( 7 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

Brain Metabolism Alterations Induced by Pregnancy Swimming Decreases Neurological Impairments Following Neonatal Hypoxia-Ischemia in Very Immature Rats

et al. 2018

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Introduction: Prematurity, through brain injury and altered development is a major cause of neurological impairments and can result in motor, cognitive and behavioral deficits later in life. Presently, there are no well-established effective therapies for preterm brain injury and the search for new strategies is needed. Intra-uterine environment plays a decisive role in brain maturation and interventions using the gestational window have been shown to influence long-term health in the offspring. In this study, we investigated whether pregnancy swimming can prevent the neurochemical metabolic alterations and damage that result from postnatal hypoxic-ischemic brain injury (HI) in very immature rats.Methods: Female pregnant Wistar rats were divided into swimming (SW) or sedentary (SE) groups. Following a period of adaptation before mating, swimming was performed during the entire gestation. At postnatal day (PND3), rat pups from SW and SE dams had right common carotid artery occluded, followed by systemic hypoxia. At PND4 (24 h after HI), the early neurochemical profile was measured by 1H-magnetic resonance spectroscopy. Astrogliosis, apoptosis and neurotrophins protein expression were assessed in the cortex and hippocampus. From PND45, behavioral testing was performed. Diffusion tensor imaging and neurite orientation dispersion and density imaging were used to evaluate brain microstructure and the levels of proteins were quantified.Results: Pregnancy swimming was able to prevent early metabolic changes induced by HI preserving the energetic balance, decreasing apoptotic cell death and astrogliosis as well as maintaining the levels of neurotrophins. At adult age, swimming preserved brain microstructure and improved the performance in the behavioral tests.Conclusion: Our study points out that swimming during gestation in rats could prevent prematurity related brain damage in progeny with high translational potential and possibly interesting cost-benefits.HIGHLIGHTS - Prematurity is a major cause of neurodevelopmental impairments;- Swimming during pregnancy reduces brain damage after HI injury;- Pregnancy is an important but underestimated preventive window.

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Section: Introductionmentioning

confidence: 99%

Brain Metabolism Alterations Induced by Pregnancy Swimming Decreases Neurological Impairments Following Neonatal Hypoxia-Ischemia in Very Immature Rats

et al. 2018

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“…13,22 A heightened level of DHEA among newborns administered pharmaceuticals during labour is also consistent with studies showing elevated DHEA in newborns as a result of illness, infection or complication during pregnancy and delivery. 35,37,38 It may be that the same underlying mechanism that precipitated administration of misoprostol or tramadol also elicited a rise in DHEA levels. The need to receive these medications may also be a marker of foetal distress leading to elevated DHEA production.…”

Section: Discussionmentioning

confidence: 99%

“…[34][35][36] Elevated levels of DHEA or DHEA-S have also been reported as a result of illness or complications during pregnancy or labour. 37,38 A paucity of research on DHEA early in life has made it difficult to establish reference levels in newborns and determine the extent to which perinatal exposures contribute to shaping early HPA axis function. To address these gaps, we report the first study of salivary DHEA in newborns.…”

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confidence: 99%

Dehydroepiandrosterone at birth: Response to stress and relation to demographic, pregnancy and delivery factors

Kamin

Bhatt

Mulligan

et al. 2020

J Neuroendocrinology

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As a hormonal product of the stress-responsive hypothalamic-pituitary-adrenal (HPA) axis, dehydroepiandrosterone (DHEA) provides a quantifiable index of activity of the HPA system and how it changes during stress. Moreover, because DHEA, along with its sulphated form, DHEA-S, is the most abundant hormone in the human body and reaches peak levels during the perinatal period, the assessment of DHEA concentrations at birth provides important information on functioning of the biological stress system with implications for health and development. However, few studies have examined DHEA levels among newborns, and those studies assessed only basal levels and not change after stress. There are already many published reports on basal and

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“…The expression of GPR30 in neurons and astrocytes has been demonstrated using pharmacological approaches (Lee et al 2012, Tang et al 2014, though the presence of Gq-mER in glial cells has not been fully demonstrated. Many reports have indicated that, at least in the mammalian brain, neurons and glia respond specifically to estradiol through ERs, even though the exact contribution of ERα, ERβ, GPR30 and Gq-mER in each neural cell type has not been established (Shughrue et al 1997, Toran-Allerand et al 1999, Hübner et al 2015.…”

Section: Estradiol Receptors: 'Classical' and 'Non-classical' Pathwaysmentioning

confidence: 99%

Sex steroid hormones as neuroprotective elements in ischemia models

Rubio

Pérez-Álvarez

Chala

2018

Journal of Endocrinology

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Among sex steroid hormones, progesterone and estradiol have a wide diversity of physiological activities that target the nervous system. Not only are they carried by the blood stream, but also they are locally synthesized in the brain and for this reason, estradiol and progesterone are considered 'neurosteroids'. The physiological actions of both hormones range from brain development and neurotransmission to aging, illustrating the importance of a deep understanding of their mechanisms of action. In this review, we summarize key roles that estradiol and progesterone play in the brain. As numerous reports have confirmed a substantial neuroprotective role for estradiol in models of neurodegenerative disease, we focus this review on traumatic brain injury and stroke models. We describe updated data from receptor and signaling events triggered by both hormones, with an emphasis on the mechanisms that have been reported as 'rapid' or 'cytoplasmic actions'. Data showing the therapeutic effects of the hormones, used alone or in combination, are also summarized, with a focus on rodent models of middle cerebral artery occlusion (MCAO). Finally, we draw attention to evidence that neuroprotection by both hormones might be due to a combination of 'cytoplasmic' and 'nuclear' signaling.

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Role of sex steroids and their receptors in human preterm infants: Impacts on future treatment strategies for cerebral development

Cited by 20 publications

References 94 publications

Brain Metabolism Alterations Induced by Pregnancy Swimming Decreases Neurological Impairments Following Neonatal Hypoxia-Ischemia in Very Immature Rats

Brain Metabolism Alterations Induced by Pregnancy Swimming Decreases Neurological Impairments Following Neonatal Hypoxia-Ischemia in Very Immature Rats

Dehydroepiandrosterone at birth: Response to stress and relation to demographic, pregnancy and delivery factors

Sex steroid hormones as neuroprotective elements in ischemia models

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