Role of SH3GLB1 in the regulation of CD133 expression in GBM cells
Chia-Hung Chien,
Chien-Cheng Lai,
Jian-Ying Chuang
et al.
Abstract:Background
Glioblastoma (GBM), a malignant brain tumor, has poor survival outcomes due to recurrence or drug resistance. We found that SH3GLB1 is a crucial factor for cells to evade temozolomide (TMZ) cytotoxicity through autophagy-mediated oxidative phosphorylation, which is associated with CD133 levels. Therefore, we propose that SH3GLB1 participate in the impact on tumor-initiating cells (TICs).
Methods
The parental, the derived resistant cell l… Show more
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