2009
DOI: 10.1055/s-0029-1241836
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Role of Short Chain Fatty Acids in Mesenteric Ischemia Reperfusion Injury in Rats

Abstract: Short chain fatty acids significantly decreased the degree of reperfusion injury in the gut in a rat model of mesenteric ischemia reperfusion.

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Cited by 5 publications
(5 citation statements)
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“…These have shown to reduce the degree of IRI in rat gut using a model of mesenteric ischemia reperfusion (92). Therefore modulation of neutrophils through GPR43 could be a possible future avenue to modulate neutrophil recruitment to organs following IRI.…”
Section: Neutrophil Targeting Therapeutics To Treat Irimentioning
confidence: 99%
“…These have shown to reduce the degree of IRI in rat gut using a model of mesenteric ischemia reperfusion (92). Therefore modulation of neutrophils through GPR43 could be a possible future avenue to modulate neutrophil recruitment to organs following IRI.…”
Section: Neutrophil Targeting Therapeutics To Treat Irimentioning
confidence: 99%
“…For example, impaired production of cytoprotective molecules such as short-chain fatty acids in GF mice may explain their increased susceptibility to I/R injury. 32 In summary, this study identified IEC-derived Myd88 signaling as promoting I/R-induced injury. We showed that IEC-derived MyD88 signaling leads to increased basal levels of luminal IgA and activated complement in ischemic tissue.…”
Section: Discussionmentioning
confidence: 67%
“…Generation of bacterial-derived products such as short-chain fatty acids has been shown to help maintain intestinal homeostasis and responses to injury. 32,33 Further studies would be required to identify the mechanism by which bacteria mediate protective effects after I/R exposure.…”
Section: Discussionmentioning
confidence: 99%
“…For example, impaired production of cytoprotective molecules such as short-chain fatty acids in GF mice may explain their increased susceptibility to I/R injury. 32 …”
Section: Discussionmentioning
confidence: 99%