Role of signal transduction and actin in G1 phase progression

Opstal, Angélique van; Bijvelt, Jose J.M.; Margadant, Coert; Boonstra, Johannes

doi:10.1016/j.advenzreg.2005.02.015

Cited by 6 publications

(6 citation statements)

References 50 publications

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“…In the mitotic phase, actin filaments are also involved in chromosome segregation by anchoring onto the microtubules [43]. The effects of ADF/cofilin on cell cycle include (1) providing the mechanical force for division of daughter cells during cytokinesis and (2) regulating the actin dynamics for signal transductions in the G1 phase [44,45]. To regulate the actin dynamic during mitosis, the ADF/cofilin activity is suppressed by LIMK 1 and 2 in the metaphase [46,47], but reactivated by slingshot homolog 1 (SSH-1) phosphatase after the telophase [7].…”

Section: Adf/cofilin and Cell Cyclementioning

confidence: 99%

Focus on ADF/Cofilin: Beyond Actin Cytoskeletal Regulation

Tsai¹,

Lee²

2012

ISRN Cell Biology

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Actin depolymerizing factor (ADF)/cofilin, an actin binding protein ubiquitously expressed in a variety of organisms, is required for regulation of actin dynamics. The activity of ADF/cofilin is dependent on serine 3 phosphorylation by LIM kinase (LIMK), which is regulated by the Rho small GTPase signaling pathway. ADF/cofilin is strongly associated with several important cell biological functions, including cell cycle, morphological maintenance and locomotion. These functions affect several biological events, including embryogenesis, oncology, nephropathy and neurodegenerations. Here, we focus on the biochemical and pathophysiological role of ADF/cofilin in mammals.

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Section: Adf/cofilin and Cell Cyclementioning

confidence: 99%

Focus on ADF/Cofilin: Beyond Actin Cytoskeletal Regulation

Tsai¹,

Lee²

2012

ISRN Cell Biology

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“…In addition, ECM components are able to bind to receptors (integrins) resulting in activation and subsequent signal transduction. Recent evidence has indicated that both receptor systems closely influence each other [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Targeted Therapies of the RAF-MEK and PI3KAKT Pathways in Cancer Treatment

Boonstra¹

2012

CCTR

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The RAF-MEK and PI3K-AKT pathways are both frequently deregulated in cancer, and often play a critical role in oncogenesis. In the previous years, major progress has been made in the development of targeted drugs against signaling kinases which are involved in carcinogenesis. Currently, targeted drugs against RAF, MEK, PI3K and AKT (among several others) have entered clinical investigation. Here we describe tumor causing mutations of these kinases, as well as the small molecule inhibitors that target these kinases, which contributes to improved ways of treating human cancer.

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“…These observations suggest that PI 3-kinase activity during mitosis and immediately after mitosis is essential for normal cell-cycle progression. 59 …”

Section: B the Phosphatidylinositol 3 Kinase Pathwaymentioning

confidence: 99%

“…Interestingly, preliminary results in our laboratory demonstrate that inhibition of PI 3-kinase during early G1 phase of the ongoing cell cycle results in inhibition of cell-cycle progression, in contrast to inhibition of PI 3-kinase during midand late G1 phase. 59 …”

Section: Transcription and G1-phase Progressionmentioning

confidence: 99%

Signal Transduction and Actin in the Regulation of G1-Phase Progression

Boonstra

Moes

2005

Crit Rev Eukar Gene Expr

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Regulation of cell proliferation is dependent on the integration of signal transduction systems that are activated by external signal molecules, such as growth factors and extracellular matrix components. Dependent on these signal transduction networks, the cells decide in the G1 phase to continue proliferation or, alternatively, to stop cell-cycle progression and undergo apoptosis, differentiation, or quiescence. The MAP kinase and PI-3 kinase pathways have been demonstrated to play an essential role in these G1-phase decisions. Interestingly, actin has been demonstrated to mutually interfere with signal transduction. In addition, it has been indicated that the FOXO transcription factors are involved in these decisions, as well. Actin has been demonstrated to play an important role in the regulation of G1-phase progression. Because of its properties as a structural protein, actin is essential in cytokinesis and in cell spreading and, thus, is involved in G1-phase progression. As an intermediate factor in signal transduction, actin is likely to be involved in cell-cycle regulation induced by external signal molecules. And, finally, actin has been demonstrated to play a direct role in transcription. These observations indicate a prominent role of actin in the regulation of G1-phase progression.

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Role of signal transduction and actin in G1 phase progression

Cited by 6 publications

References 50 publications

Focus on ADF/Cofilin: Beyond Actin Cytoskeletal Regulation

Focus on ADF/Cofilin: Beyond Actin Cytoskeletal Regulation

Recent Developments in Targeted Therapies of the RAF-MEK and PI3KAKT Pathways in Cancer Treatment

Signal Transduction and Actin in the Regulation of G1-Phase Progression

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