Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial

Abstract

Use of silicone derivative and onion extract had been reported in the prevention of hypertrophic scarring. Our experience showed the preventive use of silicone derivative plus onion extract gel on hypertrophic scars after median sternotomy. In a randomized, double blinded, placebo-controlled study, 60 patients after median sternotomy incisions were separated into two groups. All patients were treated either with silicone derivative plus onion extract gel (Cybele(®) scagel) or placebo gel twice daily for a total treatment period of 12 weeks. During each visit, pain and itching scores were graded by the patients and scar characteristics were observed by surgeons using the Vancouver scar scale. Pain and itch score values from patients' who applied silicone derivative plus onion extract gel was less than another group (P < 0·05). Pigmentation was significantly different between two groups (P < 0·05) and the reduction of scores on vascularity, pliability, height in treated group was not superior to the untreated group. No adverse events were reported by any of the patients. A silicone derivative plus onion extract gel is safe and effective for the preventing the hypertrophic scarring after median sternotomy.

Prospective randomize-controlled comparison between silicone plus herbal extract gel versus Aloe vera gel for burn scar prophylaxis

“…Although it has an effect on vascularity, itch and pain parameters, there are other compounds in silicone plus herbal extract gel in study group, which can improve the effect on itch, pain and hypervascular conditions. These compounds were reported in studies on the prevention of hypertrophic scar formation [10][11][12]. Nano Hydroxyprolisilane CN or silicone gel derivative generates static electricity and can help in the alignment of collagen fibers.…”

Vacuum assisted closure therapy for treatment of complex wounds in replanted extremities

“…There are some biomaterials, such as silver containing wound dressing, collagen gel wound dressing, silicone derivative foam dressing, biologic dressing, and artificial dermis, which not only promote wound healing, but also alleviate pain and decrease infection. Unfortunately, these materials are not available in our practice.…”

Biological approaches for hypertrophic scars

“…In another study of some children undergoing a median sternotomy, the incidences of HSs were significantly decreased by the application of onion extract . Furthermore, the combination of silicone derivative and onion extract relieved the itch and pain effectively more than the former alone, and the Vancouver Scar score was improved obviously …”

“…38 Furthermore, the combination of silicone derivative and onion extract relieved the itch and pain effectively more than the former alone, and the Vancouver Scar score was improved obviously. 39 Resveratrol, a natural plant polyphenol and phytoestrogen derived from grape and peanuts, 40,41 is proved to have many beneficial functions, including antiinflammatory and anti-oxidant properties. [42][43][44] In fibroblasts derived from HSs, resveratrol reduced their proliferation through cell cycle arrest at G1 and induce their apoptosis.…”