Role of single-cell ferroptosis regulation in intercellular communication and skin cutaneous melanoma progression and immunotherapy

Song, Binyu; Peng, Yixuan; Zheng, Yu; Zhu, Yuhan; Liu, Wei; Wang, Kai; Cui, Zhiwei; Song, Baoqiang

doi:10.1007/s00262-023-03504-5

Cited by 3 publications

(1 citation statement)

References 63 publications

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“… 17 , 18 Similarly, ferroptosis, characterized by iron‐dependent lipid peroxidation and accumulation of reactive oxygen species (ROS), has garnered attention for its role in SKCM pathogenesis. 19 The dysregulation of ferroptosis‐related pathways, including disturbances in iron metabolism and lipid peroxidation, may potentially underlie the progression of SKCM and the emergence of therapeutic resistance. 20 , 21 Targeting dysregulated PCD pathways holds promise for the treatment of SKCM and overcoming therapeutic resistance, representing a significant area of investigation in cancer research.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and significance of programmed cell death‐related gene expression signature in skin cutaneous melanoma

Wu,

Chen,

et al. 2024

Skin Research and Technology

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BackgroundProgrammed cell death (PCD) pathways play crucial roles in the pathogenesis of skin cutaneous melanoma (SKCM). Understanding their prognostic significance and clinical implications is imperative for the development of personalized treatment strategies.MethodsA total of 1466 PCD‐related genes were analyzed using data from The Cancer Genome Atlas (TCGA)‐SKCM cohort (n = 353). Prognostic cell death index (CDI) was established and validated through survival analysis and predictive modeling. Functional enrichment, protein‐protein interaction (PPI), consensus clustering, and tumor microenvironment assessment and drug sensitivity analysis were performed to elucidate the biological and clinical relevance of CDI.ResultsCDI effectively stratified SKCM patients into high and low‐risk groups, demonstrating significant differences in survival outcomes. It exhibited predictive value for survival at 1, 3, and 5 years. The concordance index (C‐index) was 0.794 in the training set, and 0.792 and 0.821 in the internal and external validation sets, respectively. The corresponding area under curve (AUC) was all above 0.75 in these data sets. Functional enrichment analysis revealed significant associations with immune response and inflammatory processes. PPI analysis identified key molecular modules associated with apoptosis and chemokine signaling. Consensus clustering unveiled three discernible subtypes demonstrating notable disparities in survival outcomes based on CDI expression profiles. Assessment of the tumor microenvironment highlighted correlations with immune cell infiltration such as M1 macrophages and T cells. Drug sensitivity analysis indicated tight correlations between CDI levels and response to immunotherapy.ConclusionOur comprehensive analysis establishes the prognostic significance of PCD‐related genes in SKCM. CDI emerges as a promising prognostic biomarker, offering insights into tumor biology and potential implications for personalized treatment strategies. Further validation and clinical integration of CDI are warranted to improve SKCM management and patient outcomes.

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Section: Introductionmentioning

confidence: 99%

Characteristics and significance of programmed cell death‐related gene expression signature in skin cutaneous melanoma

Wu,

Chen,

et al. 2024

Skin Research and Technology

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Integrative lactylation and tumor microenvironment signature as prognostic and therapeutic biomarkers in skin cutaneous melanoma

Zhu,

Song,

Yang

et al. 2023

J Cancer Res Clin Oncol

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Advances in integrating single-cell sequencing data to unravel the mechanism of ferroptosis in cancer

Du,

Shi,

Tan

2024

Briefings in Functional Genomics

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Ferroptosis, a commonly observed type of programmed cell death caused by abnormal metabolic and biochemical mechanisms, is frequently triggered by cellular stress. The occurrence of ferroptosis is predominantly linked to pathophysiological conditions due to the substantial impact of various metabolic pathways, including fatty acid metabolism and iron regulation, on cellular reactions to lipid peroxidation and ferroptosis. This mode of cell death serves as a fundamental factor in the development of numerous diseases, thereby presenting a range of therapeutic targets. Single-cell sequencing technology provides insights into the cellular and molecular characteristics of individual cells, as opposed to bulk sequencing, which provides data in a more generalized manner. Single-cell sequencing has found extensive application in the field of cancer research. This paper reviews the progress made in ferroptosis-associated cancer research using single-cell sequencing, including ferroptosis-associated pathways, immune checkpoints, biomarkers, and the identification of cell clusters associated with ferroptosis in tumors. In general, the utilization of single-cell sequencing technology has the potential to contribute significantly to the investigation of the mechanistic regulatory pathways linked to ferroptosis. Moreover, it can shed light on the intricate connection between ferroptosis and cancer. This technology holds great promise in advancing tumor-wide diagnosis, targeted therapy, and prognosis prediction.

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Role of single-cell ferroptosis regulation in intercellular communication and skin cutaneous melanoma progression and immunotherapy

Cited by 3 publications

References 63 publications

Characteristics and significance of programmed cell death‐related gene expression signature in skin cutaneous melanoma

Characteristics and significance of programmed cell death‐related gene expression signature in skin cutaneous melanoma

Integrative lactylation and tumor microenvironment signature as prognostic and therapeutic biomarkers in skin cutaneous melanoma

Advances in integrating single-cell sequencing data to unravel the mechanism of ferroptosis in cancer

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