Role of Single Dose Preoperative Ceftriaxone in the Control of Surgical Site Infection in a Tertiary Level Hospital

Rahman, Mohammad Mushfiqur; Rahman, Mazedur; Munim, Mamun Ibn; Haque, Shariful

doi:10.3329/fmcj.v11i1.30869

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…The study concluded no differences between the groups. 41 According to Rahman et al, 2016 a single dose of ceftriaxone given preoperatively was found to be as effective as the same, followed by an injection of ceftriaxone for two days followed by oral cefixime for five days in wound infections. 42 Our meta-analysis showed no statistically significant efficacy and safety in ceftriaxone therapy compared to the preoperative comparators.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy and Safety of Ceftriaxone in Surgical Prophylaxis: A Systematic Review and Meta-Analysis

Somakumar,

Raj,

Rodrigues

et al. 2024

Ind. J. Pharm. Edu. Res

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Introduction: Adequate antimicrobial monitoring helps identify the changing pattern of infection prevention postoperatively. The review aims at assessing the efficacy and safety of prophylactic ceftriaxone in surgical site infection. Materials and Methods: The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. A systematic search was conducted in PubMed, EMBASE, and CINAHL databases. Randomized control trials, published till December 2022 in English, studying only preoperative ceftriaxone, and focusing on general surgical procedures were included. Meta-analysis was done using review manager software. Results: Of the 2961 articles, nine were included in the review. Elevated gram-positive (33%) and gram-negative (67%) isolates were observed from the surgical site post-prophylaxis. Surgical site infection was developed in 53 (3.41%) patients in the ceftriaxone group and 108 (6.9%) patients in the comparator groups [OR 0.47 (95% CI: 0.33-0.65), p<0.0001]. Adverse events were assessed in six studies, from which 111 (21.4%) and 163 (31.2%) patients in the intervention and comparator groups developed the same [RR: 0.56 (95% CI: 0.31-1.01), p=0.06]. An overall estimate of [MD: -1.12 (95%CI: -1.36 to -0.89), p<0.00001)] was obtained on assessing hospital stays in the included articles. Conclusion: The evidence generated identified various microbial isolates from the infected sites. The drug assured its efficacy profile in surgical prophylaxis. More studies in general surgery can give a better conclusion about ceftriaxone prophylaxis.

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Section: Discussionmentioning

confidence: 99%

Clinical Efficacy and Safety of Ceftriaxone in Surgical Prophylaxis: A Systematic Review and Meta-Analysis

Somakumar,

Raj,

Rodrigues

et al. 2024

Ind. J. Pharm. Edu. Res

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“…Ceftriaxone (1 gm) is sufficient as a prophylaxis of surgical site infection in clean-contaminated elective surgery. 10 Pinto-Lopes et al were also unable to find any significant difference between single dose and multiple dose antibiotic prophylaxis in the incidence of postpartum infectious morbidity, endometritis and wound infection. 11 Similar result was also found in a study by Bhatnagar et al and Frank et al in 2019 found that the overall SSI rate was 5.1% in the single dose group versus 1.4% in multiple dose group without any statistical significance.…”

Section: Comparison Of Surgical Site Infectionmentioning

confidence: 94%

Comparison of single dose versus multiple doses of antibiotic prophylaxis for prevention of surgical site infection

2021

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Background: Surgical site infection is a common problem following general surgical procedures. Despite major improvement in antibiotics, improved antiseptic measures SSI continues to present a big challenge. In this study we will compare single dose versus multiple dose antibiotic prophylaxis for prevention of SSI in clean and clean contaminated surgical wound.Methods: This is an institution based prospective, comparative study, with total 60 patients as study population. Clinical finding, wound swab culture and routine haematological reports were taken as study variables. Patients receiving single dose antibiotic and multiple dose antibiotic were included in ‘Group A’ and ‘Group B’ respectively. The surgical sites were examined from post-operative days 3 to 8 for signs of infection.Results: In This study, 46.7% patients were female, and 53.3% patients were male. In Group-A, patients having post operative fever, tachycardia and leucocytosis were 16.7%, 13.3% and 20.0% respectively. 6.7% patients had purulent and 10.0% patients had seropurulent discharge from wound. In Group-B, patients having post operative fever, tachycardia, and leucocytosis were 13.3%, 16.7% and 13.3% respectively. 6.7% patients had purulent and seropurulent discharge from wound. There is no statistically significant difference between two groups regarding post operative fever, tachycardia, leucocytosis and wound discharge.Conclusions: There is no significant difference between single dose and multiple dose antibiotic prophylaxis to prevent SSI in patients for elective clean and clean contaminated surgery however single dose is more cost effective.

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Role of Single Dose Preoperative Ceftriaxone in the Control of Surgical Site Infection in a Tertiary Level Hospital

Cited by 2 publications

References 4 publications

Clinical Efficacy and Safety of Ceftriaxone in Surgical Prophylaxis: A Systematic Review and Meta-Analysis

Clinical Efficacy and Safety of Ceftriaxone in Surgical Prophylaxis: A Systematic Review and Meta-Analysis

Comparison of single dose versus multiple doses of antibiotic prophylaxis for prevention of surgical site infection

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