Role of sirtuin1 in impairments of emotion-related behaviors in mice with chronic mild unpredictable stress during adolescence

Takaba, Rika; Ibi, Daisuke; Watanabe, Kenji; Hayakawa, Kota; Nakasai, Genki; Hiramatsu, Masayuki

doi:10.1016/j.physbeh.2022.113971

Cited by 12 publications

(2 citation statements)

References 76 publications

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“…Forced-swimming test (FST) was performed to measure depression-like behavior as described previously, with minor modifications ( Takaba et al, 2022 ). Mice were individually placed in a clear beaker (19.3 cm in height, 13.1 cm in diameter; IWAKI, Tokyo, Japan) at a depth of 15 cm under water (25 ± 1°C) to ensure that mice could not touch the bottom of the beaker with their hind paws and tails and; allowed to swim freely for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice

Takaba,

Ibi,

Yoshida

et al. 2023

Preprint

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Serotonergic psychedelics such as psilocybin, lysergic acid diethylamide, and DOI exert a hallucinatory effect through serotonin 5-HT 2A receptor (5-HT2A) activation. Recent studies have revealed that serotonergic psychedelics have therapeutic potential for neuropsychiatric disorders, including major depressive and anxiety-related disorders. However, the involvement of 5-HT2A in mediating the therapeutic effects of these drugs remains unclear. In this study, we ethopharmacologically analyzed the role of 5-HT2A in the occurrence of anxiolytic-and antidepressant-like effects of serotonergic psychedelics such as psilocin, an active metabolite of psilocybin, DOI, and TCB-2 in mice. Mice with acute intraperitoneal psychedelic treatment exhibited significantly shorter immobility times in the forced swimming test (FST) and tail-suspension test (TST) than vehicle-treated control mice 24 h post-treatment. These effects were eliminated by pretreatment with volinanserin, a 5-HT2A antagonist. Surprisingly, the decreasing immobility time in the FST in response to acute psilocin treatment was sustained for at least three weeks. In the novelty-suppressed feeding test (NSFT), the latency to feed, an indicator of anxiety-like behavior, was decreased by acute administration of psilocin; however, pretreatment with volinanserin did not diminish this effect. In contrast, DOI and TCB-2 did not affect the NSFT performance in mice. Furthermore, psilocin, DOI, and TCB-2 treatment did not affect the spontaneous locomotor activity or head-twitch response, a hallucination-like behavior in rodents. These results suggest that 5-HT2A contributes to the antidepressant effects of serotonergic psychedelics rather than an anxiolytic effects.

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Section: Methodsmentioning

confidence: 99%

Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice

Takaba,

Ibi,

Yoshida

et al. 2023

Preprint

Self Cite

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“…SIRT1 stimulation appears to counteract bone loss and prevent chondrocyte degeneration [ 31 ]. Some model studies (in primary rat astrocytes [ 32 ] and animal models of depression [ 33 , 34 ]) suggest that SIRT1 activation may protect against neurodegeneration. SIRT1-dependent autophagy seems to protect cardiovascular tissues against inflammation, oxidative stress, and aging [ 35 ].…”

Section: Sirt1 and Its Mutual Interactions With Estrogen Receptorsmentioning

confidence: 99%

Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies

Karolczak,

Watala

2023

IJMS

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Aging entails the inevitable loss of the structural and functional integrity of cells and tissues during the lifetime. It is a highly hormone-dependent process; although, the exact mechanism of hormone involvement, including sex hormones, is unclear. The marked suppression of estradiol synthesis during menopause suggests that the hormone may be crucial in maintaining cell lifespan and viability in women. Recent studies also indicate that the same may be true for men. Similar anti-aging features are attributed to sirtuin 1 (SIRT1), which may possibly be linked at the molecular level with estradiol. This finding may be valuable for understanding the aging process, its regulation, and possible prevention against unhealthy aging. The following article summarizes the initial studies published in this field with a focus on age-associated diseases, like cancer, cardiovascular disease and atherogenic metabolic shift, osteoarthritis, osteoporosis, and muscle damage, as well as neurodegenerative and neuropsychiatric diseases.

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Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice

Takaba,

Ibi,

Yoshida

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Role of sirtuin1 in impairments of emotion-related behaviors in mice with chronic mild unpredictable stress during adolescence

Cited by 12 publications

References 76 publications

Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice

Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice

Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies

Ethopharmacological evaluation of antidepressant-like effect of serotonergic psychedelics in C57BL/6J male mice

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