Role of skin and gut microbiota in the pathogenesis of psoriasis, an inflammatory skin disease

Hsu, Daniel K.; Fung, Maxwell A.; Chen, Hung-Lin

doi:10.1016/j.medmic.2020.100016

Cited by 50 publications

(35 citation statements)

References 86 publications

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“…Research on the microbiome has used a variety of analysis techniques: cultured bacterial polymerase chain reaction (PCR), species-specific PCR, 16S rRNA (ribosomal ribonucleic acid) gene fragment, or full-length PCR, which hindered the possibility of an objective comparison of the test results [ 4 ]. However, the non-culture-dependent methods—DNA (deoxyribonucleic acid) and ribosomal RNA sequencing—resulted in the development of research on the microbiome.…”

Section: Resultsmentioning

confidence: 99%

“…In the most recent studies on the microbiome, the sequencing of 16S rRNA V1–3 and V3–V4 regions, which is more effective and cheaper than metagenomic shotgun sequencing, was performed. In several papers, investigators indicated that V1–V3 amplicons give more informative data in cutaneous microbiome analysis, while V4 and V3–V4 are more appropriate in gut microbiome research [ 4 ]. The Human Microbiome Project, a huge project investigating the human microbiome with the use of 16S rRNA sequencing, enabled the dynamic development of further research on a specific ecosystem inhabiting the human body [ 6 , 7 ].…”

Section: Resultsmentioning

confidence: 99%

“…Non-culture techniques of skin microbiome analysis in psoriasis revealed a decreased abundance of Burkholderia spp., Corynebacterium spp., Lactobacillus spp. and Cutibacterium , with an increased generation of Streptococcus when compared to healthy controls [ 4 , 12 , 17 ]. Studies have shown inconsistent results on the abundance of Staphylococcus [ 9 , 16 , 21 , 22 , 23 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…Various drugs have been proposed in the treatment of this condition, such as topical medications based on corticosteroids and vitamin D derivatives, and systemic treatments based on suppressions of various inflammatory axes [ 2 , 3 ]. It has been shown that patients with psoriasis develop Crohn’s disease three times more often than the general population, while patients with Crohn’s disease will develop psoriasis seven times more often than the general population [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis

Olejniczak-Staruch

Ciążyńska

Sobolewska-Sztychny

et al. 2021

IJMS

126

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Numerous scientific studies in recent years have shown significant skin and gut dysbiosis among patients with psoriasis. A significant decrease in microbiome alpha-diversity (abundance of different bacterial taxa measured in one sample) as well as beta-diversity (microbial diversity in different samples) was noted in psoriasis skin. It has been proven that the representation of Cutibacterium, Burkholderia spp., and Lactobacilli is decreased and Corynebacterium kroppenstedii, Corynebacterium simulans, Neisseria spp., and Finegoldia spp. increased in the psoriasis skin in comparison to healthy skin. Alterations in the gut microbiome in psoriasis are similar to those observed in patients with inflammatory bowel disease. In those two diseases, the F. prausnitzii, Bifidobacterium spp., Lactobacillus spp., Parabacteroides and Coprobacillus were underrepresented, while the abundance of Salmonella sp., Campylobacter sp., Helicobacter sp., Escherichia coli, Alcaligenes sp., and Mycobacterium sp. was increased. Several research studies provided evidence for the significant influence of psoriasis treatments on the skin and gut microbiome and a positive influence of orally administered probiotics on the course of this dermatosis. Further research is needed to determine the influence of the microbiome on the development of inflammatory skin diseases. The changes in microbiome under psoriasis treatment can serve as a potential biomarker of positive response to the administered therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis

Olejniczak-Staruch

Ciążyńska

Sobolewska-Sztychny

et al. 2021

IJMS

126

View full text Add to dashboard Cite

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“…The administration of oral probiotics results in the stabilisation of the bacterial community, lowering the pH in gut lumen and producing bacteriocins, as the administered bacteria compete with pathogens. This may result in the restoration of the correct bacterial microbiota composition [ 33 , 68 , 81 , 82 ].…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and Gut Microbiome—Current State of Art

Polak

Bergler‐Czop

Szczepanek

et al. 2021

IJMS

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Psoriasis is a chronic, immune-mediated inflammatory disease that affects around 125 million people worldwide. Several studies concerning the gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. Certain parameters such as Firmicutes/Bacteroidetes ratio or Psoriasis Microbiome Index were developed in order to distinguish between psoriatic and healthy individuals. The “leaky gut syndrome” and bacterial translocation is considered by some authors as a triggering factor for the onset of the disease, as it promotes chronic systemic inflammation. The alterations were also found to resemble those in inflammatory bowel diseases, obesity and certain cardiovascular diseases. Microbiota dysbiosis, depletion in SCFAs production, increased amount of produced TMAO, dysregulation of the pathways affecting the balance between lymphocytes populations seem to be the most significant findings concerning gut physiology in psoriatic patients. The gut microbiota may serve as a potential response-to-treatment biomarker in certain cases of biological treatment. Oral probiotics administration as well as fecal microbial transplantation were most reported in bringing health benefits to psoriatic patients. However, the issue of psoriatic bacterial gut composition, its role and healing potential needs further investigation. Here we reviewed the literature on the current state of the relationship between psoriasis and gut microbiome.

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Cyclosporine‐induced psoriasiform‐lichenoid dermatosis in four dogs: Successful treatment with antibiotics and cyclosporine dosage reduction

Ike,

Ueda,

Mukosaka

et al. 2024

Vet Record Case Reports

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Four dogs received cyclosporine at dosages of 8.6–17.5 mg/kg/day for 7–10 months to treat immune‐mediated diseases. These dogs developed multiple, well‐circumscribed lichenoid plaques with erythema and hyperpigmentation; additionally, thick scales appeared around the eyes, mouth and inside the auricles, and spread to almost the entire body. On the basis of histopathological examination and medication history, the four dogs were diagnosed with cyclosporin‐induced psoriasiform‐lichenoid dermatosis. Three of the four dogs exhibited marked improvement or disappearance of the skin lesions after systemic administration of antibiotics and reduction of the cyclosporine dosage; in the other dog, the lesions disappeared after systemic administration of antibiotics. Cyclosporine‐induced psoriasiform‐lichenoid dermatosis is believed to be multifactorial, involving the immune system and resident cocci on the skin.

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Role of skin and gut microbiota in the pathogenesis of psoriasis, an inflammatory skin disease

Cited by 50 publications

References 86 publications

Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis

Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis

Psoriasis and Gut Microbiome—Current State of Art

Cyclosporine‐induced psoriasiform‐lichenoid dermatosis in four dogs: Successful treatment with antibiotics and cyclosporine dosage reduction

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