Role of Sleep Apnea and Continuous Positive Airway Pressure Therapy in the Incidence of Stroke or Coronary Heart Disease in Women

Campos‐Rodríguez, Francisco; Martínez-García, Miguel Ángel; Reyes-Núñez, Nuria; Caballero-Martínez, Isabel; Serra, Pablo Catalán; Almeida‐González, Carmen V.

doi:10.1164/rccm.201311-2012oc

Cited by 151 publications

(116 citation statements)

References 31 publications

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“…The effectiveness of CPAP therapy in improving clinical symptoms, quality of life and potential consequences associated with OSA is strongly related to compliance (7)(8)(9)(10); nevertheless, the predictors of adherence to this therapy are still not well known.…”

Section: Introductionmentioning

confidence: 99%

Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnoea and acute coronary syndrome

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnoea and acute coronary syndrome

et al. 2018

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“…The first-line treatment for patients presenting OSA is continuous positive airway pressure (CPAP) therapy [9], which significantly ameliorates symptoms as well as its cardiovascular consequences [10][11][12]. We previously showed that successful CPAP treatment improved daytime baroreflex sensitivity and nitric oxide production in patients with moderate to severe OSA, hence CPAP may reduce the risk of cardiovascular complications due to endothelial dysfunction or increased sympathetic activity [8].…”

Section: Introductionmentioning

confidence: 99%

“…When adherence is greater than 4 hours of nightly use, 46 to 83% of OSA patients were reported to be nonadherent to the treatment [13]. Increasing daily use of CPAP lowers blood pressure [10] and reduces the risk of incident stroke [11] and cardiovascular death [12]. Vascular endothelial dysfunction and structural vascular changes have been implicated as early mechanisms in the pathophysiology of hypertension and other forms of vascular disease [14].…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of CPAP treatment on endothelial function in patients with mild to moderate obstructive sleep apnea

Miyata¹,

Noda²,

Yasuda³

et al. 2017

Cardiovasc Disord Med

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Purpose: Obstructive sleep apnea (OSA) is associated with endothelial dysfunction, which may contribute to the onset of atherosclerosis and associated complications. Flow-mediated dilation (FMD) is routinely used as a noninvasive technique to evaluate endothelial function. The aim of the study was to investigate the impact of continuous positive airway pressure (CPAP) treatment on endothelial function in OSA. Methods:A cohort of twenty-five patients with OSA (age 53.8 ± 11.8 years) and 17 age-matched controls (age 48.1 ± 15.1 years) were included in the study. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using a plethysmography. FMD was evaluated using high-resolution ultrasound with a 7.5 MHz linear array transducer. The % FMD index was calculated as (maximum diameter -baseline diameter) / (baseline diameter) × 100. Maximum carotid intimamedia thickness (max IMT) was also determined.Results: % FMD was significantly lower in OSA patients compared to controls (3.3 ± 1.9 vs. 5.0 ± 1.9, P=0.009) while SBP, DBP, and max IMT did not significantly differ between the two groups. In OSA patients showing good CPAP adherence (defined as CPAP usage ≥4 h/night and 70% of nights), % FMD improved from 1.7 to 3.1 in the absence of any significant decrease in SBP or DBP. Conclusion:Although there was no difference in max IMT between OSA patients and control subjects, % FMD was significantly decreased in OSA patients. More particularly, our results suggest that good adherence to CPAP treatment might reverse endothelial dysfunction in these patients.

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“…El tratamiento tiene como objetivo resolver los signos y síntomas de la enfermedad, normalizar la calidad de sueño, disminuir el índice de apnea-hipopnea por hora (IAH/h), reducir las consecuencias de enfermedades concomitantes y disminuir la desaturación de oxígeno (8). Además, se ha evidenciado que contribuye a mejorar la calidad de vida debido al buen desarrollo de las actividades de la vida diaria y, en el área de salud pública, al disminuir los costos directos e indirectos que esta enfermedad genera.…”

Section: Introductionunclassified

Validez y confiabilidad del instrumento “Medición de la autoeficacia percibida en apnea del sueño” - SEMSA. Versión en español

Mateus-Galeano

Céspedes-Cuevas

2016

Aquichan

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Objetivo: determinar la validez y la consistencia interna del instrumento “Medición de la autoeficacia percibida en apnea del sueño” - SEMSA, versión en español, diseñado por Weaver et al. Materiales y métodos: estudio de tipo descriptivo metodológico; se determinó la validez facial y de contenido con panel de expertos y un literato bilingüe. La muestra de la validez de constructo y consistencia interna fue de 151 pacientes con síndrome de apnea hipopnea del sueño que usaron el tratamiento de presión positiva continua en la vía aérea (CPAP). Resultados: la validez facial mostró un índice de aceptabilidad superior en las tres categorías evaluadas. En la validez de contenido, 23 ítems alcanzaron un nivel de aceptabilidad satisfactorio y los 4 ítems restantes fueron susceptibles de modificación. En la validez de constructo, el análisis factorial exploratorio determinó tres factores con una varianza total explicada de 52,2 %. La consistencia interna por el alfa de Cronbach fue 0,90 para la escala total y para cada dimensión mayor de 0,84. Discusión: la varianza total explicada comparándola con el estudio original fue mayor y el alfa de Cronbach fue similar tanto en la escala total como dimensional. Conclusión: el instrumento Self Efficacy Measure Sleep Apnea, válido y homogéneo en el contexto urbano colombiano, es una herramienta relevante y objetiva acerca de las perspectivas del paciente con síndrome de apnea hipopnea del sueño sobre los riesgos asociados, el beneficio del tratamiento y el cumplimiento en el uso de presión positiva (CPAP), a pesar de las barreras percibidas.

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Role of Sleep Apnea and Continuous Positive Airway Pressure Therapy in the Incidence of Stroke or Coronary Heart Disease in Women

Abstract: In women, untreated OSA is associated with increased incidence of serious cardiovascular outcomes, particularly incident stroke. Adequate CPAP treatment seems to reduce this risk.

Cited by 151 publications

References 31 publications

Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnoea and acute coronary syndrome

Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnoea and acute coronary syndrome

Beneficial effects of CPAP treatment on endothelial function in patients with mild to moderate obstructive sleep apnea

Validez y confiabilidad del instrumento “Medición de la autoeficacia percibida en apnea del sueño” - SEMSA. Versión en español

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