Role of sleep quality in the metabolic syndrome

Koren, Dorit; Dumin, Magdalena; Gozal, David

doi:10.2147/dmso.s95120

Cited by 151 publications

(79 citation statements)

References 441 publications

(556 reference statements)

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“…There is increasing recognition that disturbances of sleep are risk factors for obesity and cardiometabolic disturbances [42]. The associations between sleep parameters and metabolic risk factors are more conflicting in children and adolescents compared to adults.…”

Section: Additional Components Of the Mets In Children And Adolescentsmentioning

confidence: 99%

“…In addition, Wang et al [45] demonstrated that both short and overlong sleep duration are associated with a higher risk of overweight/obesity in preschool-aged children and with an impairment of their lipid profile. Detailed pathophysiological pathways for these associations are unknown at present, but leptin levels and different compositions of diets seem to play a role [42]. …”

Section: Additional Components Of the Mets In Children And Adolescentsmentioning

confidence: 99%

“…OSA is characterized by repetitive pharyngeal narrowing and closure during sleep [46], snoring, and frequent nocturnal awakenings [15], leading to recurrent oxyhemoglobin desaturation, sleep fragmentation, and hypercapnia [42]. It is well recognized that obesity and specific fat depots (upper airway, tongue, and abdominal adipose deposition) predispose to OSA.…”

Section: Additional Components Of the Mets In Children And Adolescentsmentioning

confidence: 99%

“…A study reported that MetS is present in 16% of children without OSA, but in 59% of those with OSA. Likewise, all single components of MetS are associated with OSA [42]. …”

Section: Additional Components Of the Mets In Children And Adolescentsmentioning

confidence: 99%

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Novel Insights in the Metabolic Syndrome in Childhood and Adolescence

Bussler¹,

Penke²,

Flemming³

et al. 2017

Horm Res Paediatr

110

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Metabolic syndrome (MetS) is recognized as an escalating major health risk in adults as well as in children and adolescents. Its prevalence ranges from 6 to 39% depending on the applied definition criteria. To date, there is no consensus on a MetS definition for children and adolescents. However, most authors agree on essential components such as glucose intolerance, central obesity, hypertension, and dyslipidemia; each representing a risk for cardiovascular disease. Recently, associations between MetS and non-alcoholic fatty liver disease, hyperuricemia, and sleep disturbances have emerged. Biomarkers like adipocytokines are a subject of current research as they are implicated in the pathogenesis of the MetS. Epigenetics and gestational programming, especially the role of microRNA, comprise a novel, rapidly developing and promising research focus on the topic of MetS. MicroRNAs are increasingly valued for potential roles in the diagnosis, stratification, and therapeutics of MetS. Early detection of risk factors, screening for metabolic disturbances, and the identification of new therapies are major aims to reduce morbidity and mortality related to MetS. Dietary modification and physical activity are currently the only adopted treatment approaches. Pharmacological therapies and bariatric surgery are still contradictory and, therefore, are only recommended in selected high-risk cases.

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Section: Additional Components Of the Mets In Children And Adolescentsmentioning

confidence: 99%

Section: Additional Components Of the Mets In Children And Adolescentsmentioning

confidence: 99%

Section: Additional Components Of the Mets In Children And Adolescentsmentioning

confidence: 99%

“…A study reported that MetS is present in 16% of children without OSA, but in 59% of those with OSA. Likewise, all single components of MetS are associated with OSA [42]. …”

Section: Additional Components Of the Mets In Children And Adolescentsmentioning

confidence: 99%

See 2 more Smart Citations

Novel Insights in the Metabolic Syndrome in Childhood and Adolescence

Bussler¹,

Penke²,

Flemming³

et al. 2017

Horm Res Paediatr

110

View full text Add to dashboard Cite

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“…Besides sleep duration, poor sleep quality has been associated with an increased risk of metabolic syndrome (Koren, Dumin, & Gozal, 2016;Mesas et al, 2014), yet not in all studies (Petrov et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

Associations of sleep duration and quality with serum and hepatic lipids: The Netherlands Epidemiology of Obesity Study

Bos

Noordam

Berg

et al. 2018

Journal of Sleep Research

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Short and long sleep duration and poor sleep quality may affect serum and hepatic lipid content, but available evidence is inconsistent. Therefore, we aimed to investigate the associations of sleep duration and quality with serum and hepatic lipid content in a large population‐based cohort of middle‐aged individuals. The present cross‐sectional study was embedded in the Netherlands Epidemiology of Obesity (NEO) study and consisted of 4260 participants (mean age, 55 years; proportion men, 46%) not using lipid‐lowering agents. Self‐reported sleep duration and quality were assessed using the Pittsburgh Sleep Quality Index questionnaire (PSQI). Outcomes of this study were fasting lipid profile (total cholesterol, low‐density lipoprotein [LDL]‐cholesterol, high‐density lipoprotein [HDL]‐cholesterol and triglycerides), postprandial triglyceride (response) levels, and hepatic triglyceride content (HTGC) as measured with magnetic resonance spectroscopy. We performed multivariable linear regression analyses, adjusted for confounders and additionally for measures that link to adiposity (e.g. body mass index [BMI] and sleep apnea). We observed that relative to the group with median sleep duration (≈7.0 hr of sleep), the group with shortest sleep (≈5.0 hr of sleep) had 1.5‐fold higher HTGC (95% confidence interval [CI]: 1.0‐2.2). The group with PSQI score ≥ 10 had a 1.1‐fold (95% CI: 1.0‐1.2) higher serum triglyceride level compared with the group with PSQI ≤ 5. However, these associations disappeared after adjustment for BMI and sleep apnea. Therefore, we concluded that previously observed associations of shorter sleep duration and poorer sleep quality with an adverse lipid profile, may be explained by BMI and sleep apnea, rather than by a direct effect of sleep on the lipid profile.

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Angiopoietin‐2 and soluble Tie‐2 receptor plasma levels in children with obstructive sleep apnea and obesity

Gozal

Qiao

Smith

et al. 2017

Obesity

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ObjectiveObstructive sleep apnea (OSA) is a prevalent condition, especially in obese children, and is associated with increased risk for metabolic syndrome. Angiopoietins have been identified as potential biomarkers of endothelial dysfunction, and MetS. In adults, angiopoietin-2 (Ang-2) and its soluble receptor (sTie-2) are associated with diabetes, hypertension and obesity, and could be increased in children with OSA, obesity, particularly those with evidence of cardiometabolic alterations.Methods126 children (7.4±2.0 years) were consecutively recruited, underwent overnight polysomnography, endothelial function, and BMI z score assessments and a fasting blood draw the morning after the sleep study. In addition to lipid profile, glucose and insulin levels and calculation of HOMA-IR, Ang-2 and sTie-2 concentrations were determined.ResultsObese and OSA children had significantly elevated plasma Ang-2 and sTie-2 levels compared to corresponding non-obese and obese controls. Furthermore, endothelial function (Tmax) and HOMA-IR were linearly and independently associated with Ang-2 and sTie-2 levels. In a small subset of children (n=14), treatment of OSA by adenotonsillectomy resulted in reductions of Ang-2 and sTie-2 (p<0.01).ConclusionsAng-2 and sTie-2 plasma levels are increased in pediatric OSA and obesity, particularly when endothelial dysfunction or insulin resistance are detectable, and appear to decrease upon OSA treatment.

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Role of sleep quality in the metabolic syndrome

Cited by 151 publications

References 441 publications

Novel Insights in the Metabolic Syndrome in Childhood and Adolescence

Novel Insights in the Metabolic Syndrome in Childhood and Adolescence

Associations of sleep duration and quality with serum and hepatic lipids: The Netherlands Epidemiology of Obesity Study

Angiopoietin‐2 and soluble Tie‐2 receptor plasma levels in children with obstructive sleep apnea and obesity

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