Role of Small Molecule Ligands in IgE-Mediated Allergy

Khatri, Kriti; O’Malley, Andrea; Linn, C. P.; Kowal, Krzysztof; Chruszcz, M.

doi:10.1007/s11882-023-01100-2

Cited by 2 publications

(1 citation statement)

References 117 publications

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“…However, for many, HDM species are the primary source of inhalant allergies [21]. HDM feces and extracts comprise various digestive enzymes, proteases, and lipid-binding proteins that are potent allergens [23,24]. The three major species of HDM, Dermatophagoides pteronyssinus, Dermatophagoides arina, and Euroglyphus maynei, are major sources of inhaled allergens that affect an estimated 10-20% of the world's population [25].…”

Section: House Dust Mitesmentioning

confidence: 99%

Microscopic Menaces: The Impact of Mites on Human Health

Linn,

O’Malley,

Khatri

et al. 2024

IJMS

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Mites are highly prevalent arthropods that infest diverse ecological niches globally. Approximately 55,000 species of mites have been identified but many more are yet to be discovered. Of the ones we do know about, most go unnoticed by humans and animals. However, there are several species from the Acariformes superorder that exert a significant impact on global human health. House dust mites are a major source of inhaled allergens, affecting 10–20% of the world’s population; storage mites also cause a significant allergy in susceptible individuals; chiggers are the sole vectors for the bacterium that causes scrub typhus; Demodex mites are part of the normal microfauna of humans and their pets, but under certain conditions populations grow out of control and affect the integrity of the integumentary system; and scabies mites cause one of the most common dermatological diseases worldwide. On the other hand, recent genome sequences of mites provide novel tools for mite control and the development of new biomaterial with applications in biomedicine. Despite the palpable disease burden, mites remain understudied in parasitological research. By better understanding mite biology and disease processes, researchers can identify new ways to diagnose, manage, and prevent common mite-induced afflictions. This knowledge can lead to improved clinical outcomes and reduced disease burden from these remarkably widespread yet understudied creatures.

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Section: House Dust Mitesmentioning

confidence: 99%

Microscopic Menaces: The Impact of Mites on Human Health

Linn,

O’Malley,

Khatri

et al. 2024

IJMS

Self Cite

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Can Physicochemical Properties Alter the Potency of Aeroallergens? Part 2 – Impact of Physicochemical Properties

Teixeira,

Carriço-Sá,

Villa

et al. 2024

Curr Allergy Asthma Rep

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Purpose of Review A holistic perspective on how physicochemical properties modulate the allergenicity of proteins has recently been performed for food allergens, launching the challenge of a similar analysis for aeroallergens. After a first review on aeroallergen classification into protein families (Part 1), this second part (Part 2) will exploit the impact of physicochemical properties (abundance/biological function, protein structure/presence of post-translational modifications, ligand/cofactor/lipid-binding) on inhalant protein allergenicity. Recent Findings The abundance linked to biological function is correlated with increased allergenic risk for most protein families, while the loss of structural integrity with consequent destruction of conformational epitopes is well linked with decreased allergenicity. Ligand-binding effect totally depends on the ligand type being highly variable among aeroallergens. Summary Knowledge about the physicochemical properties of aeroallergens is still scarce, which highlights the need for research using integrated approaches (in silico and experimental) to generate and analyze new data on known/new aeroallergens.

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Role of Small Molecule Ligands in IgE-Mediated Allergy

Cited by 2 publications

References 117 publications

Microscopic Menaces: The Impact of Mites on Human Health

Microscopic Menaces: The Impact of Mites on Human Health

Can Physicochemical Properties Alter the Potency of Aeroallergens? Part 2 – Impact of Physicochemical Properties

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