Role of Sodium‐Dependent Vitamin C Transporter‐2 and Ascorbate in Regulating the Hypoxic Pathway in Cultured Glioblastoma Cells
Eleanor R. Burgess,
Citra Praditi,
Elisabeth Phillips
et al.
Abstract:The most common and aggressive brain cancer, glioblastoma, is characterized by hypoxia and poor survival. The pro‐tumour transcription factor, hypoxia‐inducible factor (HIF), is regulated via HIF‐hydroxylases that require ascorbate as cofactor. Decreased HIF‐hydroxylase activity triggers the hypoxic pathway driving cancer progression. Tissue ascorbate accumulates via the sodium‐dependent vitamin C transporter‐2 (SVCT2). We hypothesize that glioblastoma cells rely on SVCT2 for ascorbate accumulation, and that k… Show more
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