Role of sodium<scp>l</scp>-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design and<i>in vivo</i>pharmacokinetics study

Sadashivaiah, R; Babu, B.

doi:10.1080/03639045.2020.1791167

Cited by 3 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The currently investigated formulations include ALG/PVA/ciprofloxacin electrospun composite nanofibers [ 255 ], SA/propylene glycol/metoclopramide films [ 256 ], SA/glucosamine sulphate [ 257 ], ALG/maltose composite microneedles/insulin [ 258 ], ALG/CS/rabeprazole [ 259 ], oleic acid/SA/Na CMC/2,3,5,40-tetrahydroxystilbene 2-O-β-D-glucoside (THSG) [ 260 ], SA/CS/piplartine [ 261 ], SA/polyvinyl alcohol/quercetin [ 262 ], ALG/Hidrox-6/Hydroxytyrosol [ 263 ], sodium L-cysteine ALG/isopropyl myristate/ropinirole hydrochloride [ 264 ], ALG coated aminated nanodextrin/CS coated folate decorated aminated β-CD nanoparticles/curcumin/5-flurouracil [ 265 ] which intensified transdermal drug delivery.…”

Section: Current Advancements In Alg Formulations In Drug Deliverymentioning

confidence: 99%

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Abourehab

Singh

Pramanik

et al. 2022

IJMS

102

View full text Add to dashboard Cite

Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest in alginate formulations in biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, and bioadhesive characteristics, reiterates its future use as an efficient drug delivery matrix. Alginates, obtained from natural sources, are the colloidal polysaccharide group, which are water-soluble, non-toxic, and non-irritant. These are linear copolymeric blocks of α-(1→4)-linked l-guluronic acid (G) and β-(1→4)-linked d-mannuronic acid (M) residues. Owing to the monosaccharide sequencing and the enzymatically governed reactions, alginates are well-known as an essential bio-polymer group for multifarious biomedical implementations. Additionally, alginate’s bio-adhesive property makes it significant in the pharmaceutical industry. Alginate has shown immense potential in wound healing and drug delivery applications to date because its gel-forming ability maintains the structural resemblance to the extracellular matrices in tissues and can be altered to perform numerous crucial functions. The initial section of this review will deliver a perception of the extraction source and alginate’s remarkable properties. Furthermore, we have aspired to discuss the current literature on alginate utilization as a biopolymeric carrier for drug delivery through numerous administration routes. Finally, the latest investigations on alginate composite utilization in wound healing are addressed.

show abstract

Section: Current Advancements In Alg Formulations In Drug Deliverymentioning

confidence: 99%

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Abourehab

Singh

Pramanik

et al. 2022

IJMS

102

View full text Add to dashboard Cite

show abstract

Recent advances in polymeric transdermal drug delivery systems

Sabbagh

Kim

2022

Journal of Controlled Release

207

View full text Add to dashboard Cite

Effects of Different Types of Bile Salts on the Physical Properties of Ropinirole-Loaded

Abd

Al-Akkam

2023

Al-Rafidain J Med Sci

View full text Add to dashboard Cite

Background: Bilosomes are vesicular nanocarriers that contain bile salts, making them more flexible and resistant to degradation in the gastrointestinal tract. Objective: To evaluate the effect of two bile salts on the physical properties and stability of the ropinirole-loading bilosome. Methods: Sixteen bilosomal formulations were prepared by a reverse-phase evaporation method. Each formula includes a mixture of non-ionic surfactants (Span®60 and Tween®60), along with cholesterol and bile salts (either sodium taurocholate (STC) or sodium glycocholate (SGC). The characteristics of the bilosomal formulations (drug content, entrapment efficiency, vesicle size, polydispersity index, zeta potential, in-vitro drug release, and Fourier transform infrared spectroscopy) were evaluated. Results: The entrapment efficiency of ropinirole was reduced by using sodium glycocholate instead of sodium taurocholate. The vesicle size and zeta potential were also affected by the type of bile salt and its amount. Drug release profiles were sustained, indicating a good entrapment of ropinirole. The STC-containing bilosomes are more stable than the SGC-containing bilosomes. Bilosomal formula F5 showed the highest entrapment efficiency (64.82%), suitable vesicle size (179.8 nm), zeta potential (-9.162 mV), polydispersity index (0.5116), and in vitro drug release (62.33%) after 24 hr. Conclusion: Sodium taurocholate was more suitable for the preparation of ropinirole-loading bilosomes, with more stability of bilosomes in bile salt solution.

show abstract

Role of sodiuml-cysteine alginate conjugate and isopropyl myristate to enhance the permeation enhancing activity of BCS class III drug from TDDS; optimization by central composite design andin vivopharmacokinetics study

Cited by 3 publications

References 21 publications

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Recent advances in polymeric transdermal drug delivery systems

Effects of Different Types of Bile Salts on the Physical Properties of Ropinirole-Loaded

Contact Info

Product

Resources

About