Peripheral Receptor Targets for Analgesia 2009
DOI: 10.1002/9780470522226.ch16
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Role of Somatostatin and Somatostatin Receptors in Pain

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Cited by 4 publications
(3 citation statements)
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“…This notion is consistent with a pharmacological study by others showing that the pain-relieving effects of J-2156 are abolished in mice null for the SST4 receptor (Helyes et al, 2009). However, other somatostatin receptor subtypes are also expressed in the anatomical regions like DRGs, spinal cord and brain that are involved in the process of nociception (Bär et al, 2004, Kumar, 2009. Hence, a very minor contribution by these receptors to the observed effects of J- Finally, the work described in this thesis also shows that the SST4 receptor mediates analgesia in the state of breast cancer induced bone pain.…”
Section: Effect Of J-2156 On Perk Levels In the Lumbar Spinal Cord Ofsupporting
confidence: 90%
“…This notion is consistent with a pharmacological study by others showing that the pain-relieving effects of J-2156 are abolished in mice null for the SST4 receptor (Helyes et al, 2009). However, other somatostatin receptor subtypes are also expressed in the anatomical regions like DRGs, spinal cord and brain that are involved in the process of nociception (Bär et al, 2004, Kumar, 2009. Hence, a very minor contribution by these receptors to the observed effects of J- Finally, the work described in this thesis also shows that the SST4 receptor mediates analgesia in the state of breast cancer induced bone pain.…”
Section: Effect Of J-2156 On Perk Levels In the Lumbar Spinal Cord Ofsupporting
confidence: 90%
“…Table 2 summarizes genomic loci and associated methylation differences of the top 20 DML between low vs. high internalized stigma among adults with non-specific cLBP. These include genes that have previously been associated with pain, such as SSTR5 ( 42 ), FOXP2 ( 43 , 44 ), and IL22RA1 ( 45 ).…”
Section: Resultsmentioning
confidence: 99%
“…To our knowledge, this represents the first study correlating internalized stigma with DNAm profiles in individuals with non-specific cLBP. We report stigma-associated DNAm differences at numerous CpG sites that annotated to genes of relevance to stress and pain pathology such as SSTR5 ( 42 ), FOXP2 ( 43 , 44 ), and IL22RA1 ( 45 ). Given the high number of differentially methylated genes, we will focus this discussion on the molecular functions, enrichment pathways, and network interaction over-represented by these differentially methylated annotated genes.…”
Section: Discussionmentioning
confidence: 99%