Role of some cytokines on reproduction

Mahdi, Batool Mutar

doi:10.1016/j.mefs.2011.03.002

Cited by 17 publications

(10 citation statements)

References 31 publications

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“…This initially seems to be good for providing a Th2 environment in the oviduct because a successful reproductive process is a Th2 response manifested by increased systemic production of IL-10 and IL-4 (Kwak-Kim et al, 2003). However, evidence exists that IL-4 and IL-10 serum concentrations were higher in women with reproductive failure (Mahdi, 2011;Liang et al, 2015); unlike the present study, these studies assessed systemic concentration of cytokines. Similar to our model, Rajaei et al (2011) found that endometrial stromal cells of normal fertile women produced lower levels of IL-10 in comparison with repeated implantation failure group.…”

Section: Short Communicationmentioning

confidence: 86%

Short communication: Urea induces T helper 2 (Th2) type environment at transcriptional level and prostaglandin E2 secretion in bovine oviduct epithelial cells in culture

Kowsar

Marey

Shimizu

et al. 2016

Journal of Dairy Science

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Excess dietary protein intake in early lactation dairy cows resulting in blood urea nitrogen of greater than 19 to 20mg/dL is associated with decreased fertility. Little is known about the local interference of urea in the normal immunological environment of the oviduct that provides optimal conditions for early reproductive events. A bovine oviduct epithelial cell (BOEC) culture was used to determine how urea influences immune environment. The BOEC monolayer was supplemented with low (20mg/dL) and high (40mg/dL) concentrations of urea together with ovarian steroids, estradiol (1ng/mL) and progesterone (1ng/mL), and LH (10ng/mL) at concentrations observed during the preovulatory period. The urea values used in this study were equivalent to 9.3 and 18.7mg/dL of blood urea nitrogen, which are typically common in lactating dairy cows with low or high protein intake, respectively. Stimulation of BOEC with 40mg/dL of urea induced gene expression of IL10 and IL4, epithelial-derived T helper type 2-driving (anti-inflammatory) cytokines as well as mPGES-1 expression and prostaglandin E2 (PGE2) secretion. However, urea concentrations of both 20 and 40mg/dL failed to alter the expression of IL1B and TNFA, Th1-driving cytokines, and the gene expression of TLR4. However, a concentration of 40mg/dL of urea stimulated α 1-acid glycoprotein expression, an acute phase protein. Data from this in vitro study suggest that urea, at least in part, contributes to influence the expression of some immune-related genes toward T helper type 2 type and prostaglandin E2 secretion, leading to disruption in local environment for fertilization and early embryonic development.

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Section: Short Communicationmentioning

confidence: 86%

Short communication: Urea induces T helper 2 (Th2) type environment at transcriptional level and prostaglandin E2 secretion in bovine oviduct epithelial cells in culture

Kowsar

Marey

Shimizu

et al. 2016

Journal of Dairy Science

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“…The increased numbers of macrophages would be indicative of an inflammatory condition, while the increase in Tregs and MDSCs would be indicative of an immunosuppressive state, which opposes the necessity of immunostimulation for successful pregnancy initiation. To this extend, maternal serum collected after the 7-day l-Cn treatment showed to contain increased levels of the immunosuppressive cytokine IL-10 (P < 0.05 as compared with controls; data not shown), which has been found increased in women with reproductive failure and has been suggested to participate in early pregnancy (Mahdi 2011). By the same token, increased levels of progesterone could be detected in the 7-day l-Cn-treated pregnant mice, which could further fortify the immunosuppressive state of the mother early in pregnancy (Xu et al 2011).…”

Section: Discussionmentioning

confidence: 82%

l-Carnitine affects preimplantation embryo development toward infertility in mice

et al. 2016

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Abstractl-Carnitine (l-Cn), despite the beneficial role as energy-generating substance delivering long-chain fatty acids to the β-oxidation pathway in mitochondria, has been accused to cause an endometriosis-like state to BALB/c mice manifested by increased inflammatory cytokines in serum and peritoneal fluid, accumulation of immune cells in the peritoneal cavity and uterine walls and most importantly, correlating to infertility. Exploring this type of infertility, the effect of l-Cn on preimplantation embryo development, ovarian integrity and systemic maternal immunity was studied. Using nonlinear microscopy analysis, which was shown to be a powerful tool for determining embryo quality by quantitatively estimating the lipid body (LB) content of the cells, it was shown that in vitro and in vivo administration of l-Cn significantly decreased LB mean area in zygotes. Daily intraperitoneal administration of 2.5 mg l-Cn for 3, 4 and 7 days to mice significantly decreased the percent of normal zygotes. However, only the 7-day treatment persisted by affecting 2-and 8-cell stage embryos, while almost abolishing blastocyst development. Such effects were accompanied by abnormal ovarian histology, showing increased numbers of corpora luteus and elevated progesterone concentration in the serum. In addition, it was shown that the 7-day l-Cn treatment pushed maternal systemic immunity toward inflammation and immunosuppression by increasing CD11b-, CD25-and CD11bGr1-positive cells in spleen, which opposed the necessity for immunostimulation at these early stages of pregnancy. In conclusion, the results presented here demonstrated that elevated doses of l-Cn affect early stages of embryo development, leading to infertility.Reproduction (2016) 152 283-291

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“…Previous studies suggested that ability to generate a healthy fetus and successful in vivo fertilization occur in the oocytes in follicles with lower concentration of IL-1β in follicular fluid (Revelli et al, 2009). reason may due to IL-1β role in suppressing estradiol and progesterone release from granulosa and luteal cells (Mahdi, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Interleukins as a group of cytokines are important for reproductive processes and work as immunoregulatory molecules responsible for modulating several biological responses including the ovarian function (Calogero et al, 1998 andMahdi, 2011).…”

Section: Introductionmentioning

confidence: 99%

Alterations in Levels of Oxidative Stress Biomarkers, Some Serum Interleukins and Hormones in Infertile Women

Hamza

Abd-alrahman

2017

Journal of Garmian University

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The aim of this study was to evaluate the effect of oxidative stress and some serum interleukins and hormones levels of women with primary infertility, and to reveal the correlation between them.A total of 120 infertile women with different etiologies and 45 fertile women as a control were investigated, their age ranged between (16-45) years old. The levels of serum TAC, SOD activity, GSH, MDA, Mg, Zn, catalase activity, interleukin-1β and interleukin-8 were estimated, also the levels of LH, FSH, prolactin, progesterone, AMH, inhibin B and leptin were estimated.The current results were revealed that there was a significant elevation in the levels of MDA, interleukin-1β, prolactin and leptin, and a significant decrease in TAC, SOD, GSH, Mg, Zn, catalase activity, AMH and inhibin B between the infertile and fertile groups. There was a positive correlation between SOD with AMH, inhibin B and Mg, and positive correlation between LH and FSH, TAC and inhibin B. there was a negative correlation between FSH and inhibin B. In conclusion, it suggested that inhibin B may play a role in the antioxidant-oxidant balance.

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Role of some cytokines on reproduction

Cited by 17 publications

References 31 publications

Short communication: Urea induces T helper 2 (Th2) type environment at transcriptional level and prostaglandin E2 secretion in bovine oviduct epithelial cells in culture

Short communication: Urea induces T helper 2 (Th2) type environment at transcriptional level and prostaglandin E2 secretion in bovine oviduct epithelial cells in culture

l-Carnitine affects preimplantation embryo development toward infertility in mice

Alterations in Levels of Oxidative Stress Biomarkers, Some Serum Interleukins and Hormones in Infertile Women

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