Role of Some Serum Biomarkers in the Early Detection of Diabetic Cardiomyopathy

Abstract

Aim: To assess the role of serum biomarkers in early prediction of diabetic cardiomyopathy. Materials and methods: The participants were three groups of Type 2 diabetes mellitus (DM) patients having diastolic dysfunction (DM-DD), systolic dysfunction (DM-SD) and normal echocardiography (DM-N) with two control groups: non-DM diastolic dysfunction patients (DD) and healthy controls. AGEs, TNF-α, IL-6, IGFBP-7, creatinine and insulin were assessed. Results: TNF-α, AGEs, creatinine and insulin panel had area under the curve (AUC) of 0.913 in distinguishing DM-DD from DM-N (78.7% sensitivity and 100% specificity). IL-6 and AGEs panel had AUC 0.795 for differentiating DM-SD from DM-DD (90.6% sensitivity). IL-6, TNF-α and AGEs panel had AUC 0.924 for differentiating diabetic cardiomyopathy from DM-N (85% sensitivity and specificity). Conclusion: A panel of AGEs, IL-6, TNF-α, insulin and creatinine might be used for early detection of DM-DD among T2DM patients.

Diabetic cardiomyopathy: Clinical phenotype and practice

“…GDF-15 is a stress response cytokine that is elevated in asymptomatic DCM and significantly associated with E/e’ (diastolic function index) ( 80 ). IGFBP-7 is expected to be a marker for DCM as it increased progressively in patients with DM, DM-DD, and DM-SD (systolic dysfunction) and did not increase in DD patients without diabetes ( 79 ). Another study confirmed that NLR was positively correlated with impaired LVDD and was an independent risk factor for subclinical DCM ( 77 ), but NLR is also well correlated with other diabetic complications ( 206 ).…”

“…A study showed that the AUCs of IL-6, TNF-α, and AGEs were 0.905, 0.845, and 0.807, respectively, which could not diagnose DCM. However, the combination of these biomarkers significantly increased AUC to 0.924, with a sensitivity of 84.8% and a specificity of 88.2% ( 79 ). The union of TNF-α, AGEs, creatinine, and insulin helped diagnose DM-DD (AUC 0.913, specificity 100%) ( 79 ).…”

“…However, the combination of these biomarkers significantly increased AUC to 0.924, with a sensitivity of 84.8% and a specificity of 88.2% ( 79 ). The union of TNF-α, AGEs, creatinine, and insulin helped diagnose DM-DD (AUC 0.913, specificity 100%) ( 79 ). Nevertheless, the combination of IL-6 and AGEs was found helpful for further differential diagnosis of DM-SD and DM-DD, with an AUC of 0.795 and sensitivity of 90.6%, which was significantly better than that of a separate diagnosis ( 79 ).…”