Role of Sonographic Diagnosis in Managing Bethesda Class III Nodules

Kim, D.W.; Lee, E.J.; Jung, Soo Jin; Ryu, Ji Hwa; Kim, Y.M.

doi:10.3174/ajnr.a2686

Cited by 49 publications

(48 citation statements)

References 34 publications

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“…For children, core needle biopsy may be achieved without an increased complication risk, although the accuracy of diagnosing malignancy seems to be equivalent to FNA [21]. Although immunohistochemical panels, PET, MRI and US seem promising to predict malignancy in adult thyroid nodules, none of the methods have been trialed specifically in a pediatric population, probably because of the rareness of the disease [22][23][24][25][26][27]. Furthermore, neither of the modalities can exclude malignancy.…”

Section: Tablementioning

confidence: 94%

Risk of malignancy for each Bethesda class in pediatric thyroid nodules

Norlén

Charlton

Sarkis

et al. 2015

Journal of Pediatric Surgery

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Section: Tablementioning

confidence: 94%

Risk of malignancy for each Bethesda class in pediatric thyroid nodules

Norlén

Charlton

Sarkis

et al. 2015

Journal of Pediatric Surgery

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“…This result may be related to the exclusion of non-resected nodules that were highly likely to be benign. So far, many studies regarding the diagnoses of thyroid nodules with indeterminate cytology have been reported [18,19,20,21]. For evaluating thyroid nodules with indeterminate cytology in the initial FNA, repeated FNA, core-needle biopsy, BRAF mutation analysis, or US classification may be helpful [12,18,19,20,21], but the standard method has not been established.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Fine-Needle Aspiration of Thyroid Nodules Measuring Less than 5 mm: Effects on Specimen Adequacy and Diagnosis

Kim

Jung²,

et al. 2012

Acta Cytologica

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Objective: We aimed to assess the adequacy and efficacy of ultrasound (US)-guided fine-needle aspiration (US-FNA) for small solid thyroid nodules (SSTNs) with the largest diameter <5 mm and compared these according to nodule size. Study Design: Among 656 SSTNs in 569 patients, each SSTN was classified into 1 of 4 groups according to the largest diameter: 1 mm ≤ group A < 2 mm; 2 mm ≤ group B < 3 mm; 3 mm ≤ group C < 4 mm, and 4 mm ≤ group D < 5 mm. We compared the adequacy and efficacy of US-FNA between these groups using histopathologic results as a reference standard. Results: 571 (87.0%) SSTNs were adequately sampled by US-FNA and 200 of these were histopathologically confirmed. The adequacy of US-FNA for SSTNs varied according to the nodule diameter: the smaller the nodule diameter, the lower the diagnostic adequacy. The diagnostic efficacy of US-FNA for SSTNs showed a significant relationship with nodule size: diagnostic efficacy in groups A and B was lower than in groups C and D. Conclusions: The adequacy of US-FNA for SSTNs tended to decrease with decreased nodule size, and diagnostic efficacy of US-FNA for SSTNs with the largest diameter <3 mm was lower than for those ≥3 mm.

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“…9,10 A study in South Korea reported a malignancy rate of 47%, while an academic institution in the US reported a malignancy rate of 48%. 12,15 These reported rates are higher than the implied risk of malignancy (5-15%) adopted by the Bethesda System. These rates were extrapolated from 3 referral centers who were using a similar 6-tiered classification system long before the new system was introduced.…”

Section: Discussionmentioning

confidence: 41%

Management and Malignancy Rate of Thyroid Nodules with a Cytologic Diagnosis of Atypia or Follicular Lesion of Undetermined Significance

Carlos

Mirasol

Aquino

et al. 2014

JAFES

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Objective. This study describes the clinical data of adult patients who underwent Fine Needle Aspiration Biopsy (FNAB) of thyroid nodule(s) with a cytologic diagnosis of Atypia or Follicular Lesion of Undetermined Significance (AUS or FLUS) at St. Luke's Medical Center from January 2012 to October 2013.Methodology. Adult patients who underwent FNAB of the thyroid nodule with a cytologic diagnosis of AUS or FLUS were studied retrospectively using the ultrasound result, initial consultation form and operative techniques of these patients. The cytologic and histopathologic diagnoses were retrieved through the electronic Healthcare-Results Management System.Results and Conclusion. A third (34%) of the patients with a cytologic diagnosis of AUS or FLUS (8.9%) underwent surgery. Of the 68 patients who underwent surgery, 44 were benign and 24 were malignant with a malignancy rate of 35.3%. Preoperatively, there were no ultrasound characteristics or microscopic descriptions significantly associated with malignancy. The recommendation of the Bethesda System to do a repeat FNAB in these thyroid nodules should, therefore, be reconsidered.

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Role of Sonographic Diagnosis in Managing Bethesda Class III Nodules

Cited by 49 publications

References 34 publications

Risk of malignancy for each Bethesda class in pediatric thyroid nodules

Risk of malignancy for each Bethesda class in pediatric thyroid nodules

Ultrasound-Guided Fine-Needle Aspiration of Thyroid Nodules Measuring Less than 5 mm: Effects on Specimen Adequacy and Diagnosis

Management and Malignancy Rate of Thyroid Nodules with a Cytologic Diagnosis of Atypia or Follicular Lesion of Undetermined Significance

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