Role of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina

Henkel, Vanessa; Schürmanns, Lea; Brunner, Miriam; Hamann, Andréa; Osiewacz, Heinz

doi:10.1016/j.mad.2020.111211

Cited by 22 publications

(35 citation statements)

References 62 publications

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“…These observations suggest that Atg24 acts as a mitophagy receptor in M. oryzae, and are consistent with the notion that the conidiation defects generated by the loss of Atg24 are associated with a mitophagy deficiency [177]. Akin to M. oryzae, deletion of ATG24 results in decreased aerial mycelium formation in P. anserina [178] and in F. graminearum, as well as in a strong reduction in conidia formation in F. graminearum [179]. Similarly, the number of microconidia in P. anserina was dramatically reduced upon ATG24 deletion (see Section 7.3) [178].…”

Section: Mitophagy and Pexophagy Are Required For Asexual Sporulationsupporting

confidence: 86%

“…Akin to M. oryzae, deletion of ATG24 results in decreased aerial mycelium formation in P. anserina [178] and in F. graminearum, as well as in a strong reduction in conidia formation in F. graminearum [179]. Similarly, the number of microconidia in P. anserina was dramatically reduced upon ATG24 deletion (see Section 7.3) [178]. Nonetheless, in addition to mitophagy, Atg24 also participates in pexophagy and non-selective autophagy in P. anserina, and its contribution to selective autophagy in F. graminearum remains to be established.…”

Section: Mitophagy and Pexophagy Are Required For Asexual Sporulationmentioning

confidence: 99%

“…In this fungus, peroxisomes proliferate during ascospore differentiation, to then be significantly removed upon ascospore maturation [127]. Although the actual involvement of pexophagy in this process has not been demonstrated, the elimination of Atg24 in P. anserina causes a delay in the maturation of ascospores (issued from heterozygous crosses, see below) [178], suggesting a role for pexophagy in this process. Notably, loss of Atg24 also results in sterility in P. anserina, which is associated both, with a reduced capacity of the atg24 mutants to serve as female partners and, more prominently, to an inability to produce spermatia (male gametes).…”

Section: Sexual Development Relies On Pexophagymentioning

confidence: 99%

“…Notably, loss of Atg24 also results in sterility in P. anserina, which is associated both, with a reduced capacity of the atg24 mutants to serve as female partners and, more prominently, to an inability to produce spermatia (male gametes). Nonetheless, since P. anserina Atg24 is required for pexophagy, mitophagy, and non-selective autophagy [178], further research is needed to understand the actual contribution of these processes during P. anserina sexual development.…”

Section: Sexual Development Relies On Pexophagymentioning

confidence: 99%

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Dynamic Regulation of Peroxisomes and Mitochondria during Fungal Development

Navarro-Espíndola

Suaste-Olmos

Peraza-Reyes

2020

JoF

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Peroxisomes and mitochondria are organelles that perform major functions in the cell and whose activity is very closely associated. In fungi, the function of these organelles is critical for many developmental processes. Recent studies have disclosed that, additionally, fungal development comprises a dynamic regulation of the activity of these organelles, which involves a developmental regulation of organelle assembly, as well as a dynamic modulation of the abundance, distribution, and morphology of these organelles. Furthermore, for many of these processes, the dynamics of peroxisomes and mitochondria are governed by common factors. Notably, intense research has revealed that the process that drives the division of mitochondria and peroxisomes contributes to several developmental processes—including the formation of asexual spores, the differentiation of infective structures by pathogenic fungi, and sexual development—and that these processes rely on selective removal of these organelles via autophagy. Furthermore, evidence has been obtained suggesting a coordinated regulation of organelle assembly and dynamics during development and supporting the existence of regulatory systems controlling fungal development in response to mitochondrial activity. Gathered information underscores an important role for mitochondrial and peroxisome dynamics in fungal development and suggests that this process involves the concerted activity of these organelles.

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Section: Mitophagy and Pexophagy Are Required For Asexual Sporulationsupporting

confidence: 86%

Section: Mitophagy and Pexophagy Are Required For Asexual Sporulationmentioning

confidence: 99%

Section: Sexual Development Relies On Pexophagymentioning

confidence: 99%

Section: Sexual Development Relies On Pexophagymentioning

confidence: 99%

See 2 more Smart Citations

Dynamic Regulation of Peroxisomes and Mitochondria during Fungal Development

Navarro-Espíndola

Suaste-Olmos

Peraza-Reyes

2020

JoF

View full text Add to dashboard Cite

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“…Mutations in LMNA, which encodes nuclear Lamin A/C, precipitates a premature aging syndrome called Hutchinson-Gilford Progeria (HGPS) that is characterized by the accumulation of protein aggregates [89]. Of particular relevance to this review, a common manifestation of Lamin A/C mutations and the subsequent accumulation of progerin caused cardiac dysfunction manifested by atrial arrhythmia and hypertrophic cardiomyopathy [90,91]. Evidence supporting this link is provided by a fly model of cardiolaminopathy exhibiting repressed autophagy, accumulation of cytoplasmic Lamin C aggregates, impaired cardiac function, severe myofibrillar degeneration, nuclear morphological defects, and evidence of oxidative stress [92].…”

Section: Autophagy Suppression In Cardiac Agingmentioning

confidence: 99%

Protein and Mitochondria Quality Control Mechanisms and Cardiac Aging

Ghosh

Vinod

Symons

et al. 2020

Cells

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Cardiovascular disease (CVD) is the number one cause of death in the United States. Advancing age is a primary risk factor for developing CVD. Estimates indicate that 20% of the US population will be ≥65 years old by 2030. Direct expenditures for treating CVD in the older population combined with indirect costs, secondary to lost wages, are predicted to reach $1.1 trillion by 2035. Therefore, there is an eminent need to discover novel therapeutic targets and identify new interventions to delay, lessen the severity, or prevent cardiovascular complications associated with advanced age. Protein and organelle quality control pathways including autophagy/lysosomal and the ubiquitin-proteasome systems, are emerging contributors of age-associated myocardial dysfunction. In general, two findings have sparked this interest. First, strong evidence indicates that cardiac protein degradation pathways are altered in the heart with aging. Second, it is well accepted that damaged and misfolded protein aggregates and dysfunctional mitochondria accumulate in the heart with age. In this review, we will: (i) define the different protein and mitochondria quality control mechanisms in the heart; (ii) provide evidence that each quality control pathway becomes dysfunctional during cardiac aging; and (iii) discuss current advances in targeting these pathways to maintain cardiac function with age.

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Crosstalk between Endo/Exocytosis and Autophagy in Health and Disease

Papandreou

Tavernarakis

2020

Biotechnology Journal

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Imbalance between the main intracellular degradative, trafficking and intercellular shuttling pathways has been implicated in disease pathogenesis. Autophagy controls degradation of cellular components, while vesicular trafficking permits transport of material in and out of the cell. Emerging evidence has uncovered the extensive interconnectivity between these pathways, which is crucial to maintain organismal homeostasis. Thus, therapeutic intervention and drug development strategies targeting these processes, particularly in neurodegeneration, should account for this broad crosstalk, to maximize effectiveness. Here, recent findings underlining the highly dynamic nature of the crosstalk between autophagy, endosomal transport, and secretion is reviewed. Synergy of autophagy and endosomes for degradation, as well as, competition of autophagy and secretion are discussed. Perturbation of this crosstalk triggers pathology especially neurodegeneration.

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Role of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina

Cited by 22 publications

References 62 publications

Dynamic Regulation of Peroxisomes and Mitochondria during Fungal Development

Dynamic Regulation of Peroxisomes and Mitochondria during Fungal Development

Protein and Mitochondria Quality Control Mechanisms and Cardiac Aging

Crosstalk between Endo/Exocytosis and Autophagy in Health and Disease

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