Role of Soy Diet and L‐Arginine in Cyclosporin‐A‐Induced Osteopenia in Rats

Clementi, Giuseppe; Fiore, Carmelo Erio; Mangano, Nunzio Guido; Cutuli, V. M. C.; Pennisi, P.; Caruso, A.; Prato, A.; Matera, M; Amico‐Roxas, M.

doi:10.1034/j.1600-0773.2001.088001016.x

Cited by 17 publications

(11 citation statements)

References 17 publications

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“…Considering the role silicon plays on bone development and the bone development problems found in broilers, this study evaluated the supplementation of a silicon product in broiler drinking water for its effect on bone density, breaking strength and mineral profile. Although the silicon product supplementation did not affect bone density and tibial breaking strength, a higher mineral (P, Mn, Zn) and ash content was promoted by supplementation of the product, as previously found by Carlisle (1972), Schwarz and Milne (1972), Fiore et al (2000), Clementi et al (2001), Jugdaohsingh et al (2004 and Sahin et al (2006). However, in the aforementioned articles, silicon was added via feed, which is different from this study, where silicon was supplemented in the drinking water.…”

Section: Discussioncontrasting

confidence: 57%

Silicon in broiler drinking water promotes bone development in broiler chickens

Sgavioli

Domingues

Castiblanco

et al. 2016

British Poultry Science

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Skeletal abnormalities, bone deformities and fractures cause significant losses in broiler production during both rearing and processing. Silicon is an essential mineral for bone and connective tissue synthesis and for calcium absorption during the early stages of bone formation. Performance was not affected by the addition of silicon. However, broilers receiving silicon showed a significant increase of phosphorus, zinc, copper, manganese and ash in the tibia. In conclusion, broiler performance was not impaired by adding the tested silicon product to the drinking water. In addition, bone development improved, as demonstrated by higher mineral and ash content. Further studies are required to determine the optimal concentration of silicon, including heat stress simulations, to better understand the effects of silicon on bone development.

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Section: Discussioncontrasting

confidence: 57%

Silicon in broiler drinking water promotes bone development in broiler chickens

Sgavioli

Domingues

Castiblanco

et al. 2016

British Poultry Science

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“…Low bone mineral density (BMD) is also an important risk factor for osteoporosis and related fractures in humans (CDC, 1991). Two components of the product used in the present study, arginine and silicon can increase bone mineral content and bone density (Carlisle, 1970(Carlisle, , 1981Clementi et al, 2001). Arginine may be involved in osteoporosis and fractures or bone defects (Civitelli et al, 1992).…”

Section: Discussionmentioning

confidence: 92%

“…Arginine is involved both in the synthesis of substrates (polyamine and L-proline) implicated in collagen synthesis, and in the production of growth hormone (GH), insulin-like growth factor-I (IGF-I) and nitric oxide (Chevalley et al, 1998;Trippel, 1998;Colao et al, 1999). Arginine is clinically suggested for metabolic disturbance in calcium absorption, growth, dentition and ossification defects, rachitism, osteomalacia, decalcification and convalescence (Fiore et al, 2000;Clementi et al, 2001). Several roles for silicon have been defined, largely on the basis of animal studies (Carlisle, 1972;Schwarz and Milne, 1972).…”

Section: Introductionmentioning

confidence: 99%

Dietary arginine silicate inositol complex during the late laying period of quail at different environmental temperatures

Onderci

Şahin

et al. 2006

British Poultry Science

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Arginine silicate inositol complex (ASIdagger; arginine 49.5%, silicon 8.2%, inositol 25%) is a novel material which is a bioavailable source of silicon and arginine. ASI offers potential benefits for vascular and bone health. Poor eggshell quality has been a major economic concern to commercial egg producers. Poor egg quality, skeletal abnormalities and architectural deterioration of bone tissue are common problems under hot conditions and in older birds. The effects of ASI supplementation on egg production, egg quality, levels of osteocalcin (OC) and bone mineral content were investigated in heat-stressed Japanese quail during the later part of the laying period. The birds were randomly assigned to six treatment groups consisting of six replicates of five birds each in a 2 x 3 factorial arrangement of treatments (temperatures, ASI levels). The birds were kept in wire cages in a temperature-controlled room at either 22 degrees C (TN) or 34 degrees C (HS) for 8 h/d and fed either a basal (control) diet or the basal diet supplemented with either 500 or 1000 g of ASI/kg. Heat exposure reduced egg production, egg quality and bone mineralisation when the basal diet was fed. ASI supplementation had no effect on feed intake or egg production under TN or HS conditions. However, ASI supplementation increased egg weight, shell thickness, shell weight and Haugh unit in both TN and HS groups during the late laying period. Bone mineral density (BMD) was significantly improved by ASI supplementation in both TN and HS groups. Serum osteocalcin (OC) concentrations and alkaline phosphatase (ALP) activity increased linearly with dietary ASI supplementation during the late laying period. The amount of calcium and phosphorus in the excreta decreased, while ash, mineral content, calcium and phosphorus concentrations in tibia increased in ASI-supplemented quail in both TN and HS groups during the late laying period. ASI supplementation significantly improved egg quality and bone mineralisation in quail during the late laying period and did not affect feed consumption or egg production.

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“…However, in vitro and in vivo studies on the effect of Arg and Lys on osteoblasts suggest that they may positively affect bone metabolism (Chevalley et al, 1998;Clementi et al, 2001;Conconi et al, 2001;Fiore et al, 2000).…”

Section: Discussionmentioning

confidence: 97%

Human Osteopenic Bone‐Derived Osteoblasts: Essential Amino Acids Treatment Effects

Torricelli

Fini

Giavaresi

et al. 2003

Artificial Cells, Blood Substitutes, and Biotechnology

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The development of in vitro cell culture methods has made it possible to study bone cell metabolism and growth and obtain a deeper insight into the pathophysiology of common orthopedic diseases such as osteoporosis. After analyzing the effect of two essential amino acids, L-arginine (Arg) and L-lysine (Lys), in previous in vitro and in vivo studies, the present authors investigated the administration of Arg and Lys in osteoblasts derived from human osteopenic bone. After isolation, osteoblasts were cultured in DMEM supplemented with either Arg (0.625 mg/ml/day, Arg Group) or Lys (0.587 mg/ml/day, Lys Group), or both of them (Arg-Lys Group), whereas the Control Group was sham-treated. After 7 days the following parameters were tested in all groups: MTT proliferation test, Alkaline Phosphatase (ALP), Nitric Oxide (NO), Calcium (Ca), Phosphorus (P), Osteocalcin (OC), C-Terminal Procollagen type I (PICP), Interleukin-6 (IL-6), Transforming Growth Factor-beta 1 (TGF-beta 1), Platelet Derived Growth Factor (PDGF) and Insulin-Like Growth Factor-I (IGF-I). Results were compared with those obtained from human healthy bone to verify the effect of the amino acids on osteoblasts derived from pathological tissue. In addition, a comparison was also made with the results obtained from rat osteopenic bone to assess reliability of the in vitro model. The current results support previous findings and indicate that Arg and Lys stimulation has a positive effect on osteoblast proliferation, activation and differentiation. Therefore, administration of these amino acids may be useful in clinical treatment and prevention of osteoporosis.

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Role of Soy Diet and L‐Arginine in Cyclosporin‐A‐Induced Osteopenia in Rats

Cited by 17 publications

References 17 publications

Silicon in broiler drinking water promotes bone development in broiler chickens

Silicon in broiler drinking water promotes bone development in broiler chickens

Dietary arginine silicate inositol complex during the late laying period of quail at different environmental temperatures

Human Osteopenic Bone‐Derived Osteoblasts: Essential Amino Acids Treatment Effects

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